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5-alpha Reductase, including 5-alpha Reductase type1, 5-alpha Reductase type2, and 5-alpha Reductase type3, is an isoenzyme which can convert testosterone to dihydrotestosterone. 5-alpha Reductase is related to prostate cancer, BPH and other cancer so that 5-alpha reductase can be a target of therapeutic intervention in both benign and cancerous diseases.
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1202 | Dutasteride | Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). |
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| S1197 | Finasteride | Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). |
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| S2283 | Cinchonine(LA40221) | Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine. |
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| S2188 | Phenprocoumon | Phenprocoumon (Marcoumar, Marcumar and Falithrom,Ro 1-4849) is a vitamin K reductase with an IC50 of 1 μM |
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| S2345 | Podophyllotoxin (Podofilox) | Podophyllotoxin (Condylox,Podofilox) is a lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. | ||
| S4593 | Chlormadinone acetate | Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours. |
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