Home Endocrinology & Hormones 5-alpha Reductase

5-alpha Reductase

5-alpha Reductase, including 5-alpha Reductase type1, 5-alpha Reductase type2, and 5-alpha Reductase type3, is an isoenzyme which can convert testosterone to dihydrotestosterone. 5-alpha Reductase is related to prostate cancer, BPH and other cancer so that 5-alpha reductase can be a target of therapeutic intervention in both benign and cancerous diseases.

Other Endocrinology & Hormones Related Inhibitors

Adrenergic Receptor Androgen Receptor Estrogen/progestogen Receptor Aromatase RAAS Glucocorticoid Receptor ACE Mineralocorticoid Receptor PGDS Progesterone Receptor
Cat.No. Product Name Information Product Use Citations Product Validations
S1197 Finasteride Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
PLoS One, June 2, 2016, e0156549
Frontiers in Pharmacology, February 20, 2023, 1038039
Biochem Pharmacol, 2025, 241:117171
S1202 Dutasteride Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
Chemical and Pharmaceutical Bulletin, 2025, 857-867
Neoplasia, 2024, 101045
Neoplasia, 2024, 57:101045
S2283 Cinchonine(LA40221) Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine.
CNS Neuroscience & Therapeutics, 2024 Feb, e14403
CNS Neuroscience & Therapeutics, 2024, e14403
CNS Neurosci Ther, 2023, 10.1111/cns.14403
S2188 Phenprocoumon Phenprocoumon (Marcoumar, Marcumar and Falithrom,Ro 1-4849) is a vitamin K reductase with an IC50 of 1 μM
J Immunother Cancer, 2024, 12(11)e009805
S2345 Podophyllotoxin (Podofilox) Podophyllotoxin (Condylox,Podofilox) is a lignan (lignans) found in podophyllin resin from the roots of podophyllum plants.
Science Advances, 2019, eaav9784
S4593 Chlormadinone acetate Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours.

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