For research use only.

Catalog No.S1197 Synonyms: MK-906

3 publications

Finasteride Chemical Structure

Molecular Weight(MW): 372.54

Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).

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Biological Activity

Description Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
5-α reductase [1]
10.2 nM(Ki)
In vitro

Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 1.62 ms. [1] Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. [2] Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells. [3]

In vivo Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. Finasteride also causes decreased anogenital distance in male offspring in male rats. [4] Finasteride and castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats. Finasteride-induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to control values by day 9 in rats. [5]


Solubility (25°C)

In vitro DMSO 75 mg/mL (201.32 mM)
Ethanol 75 mg/mL (201.32 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 372.54


CAS No. 98319-26-7
Storage powder
in solvent
Synonyms MK-906

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04288427 Not yet recruiting Drug: Finasteride Benign Prostatic Hyperplasia|Prostate Hyperplasia|Prostate Disease|Prostate Hypertrophy|Prostate Pain|Lower Urinary Tract Symptoms|Urinary Obstruction|Urinary Tract Disease Beth Israel Deaconess Medical Center April 2020 Not Applicable
NCT03669692 Recruiting Behavioral: Caloric Restriction|Behavioral: Control Prostatic Hyperplasia Benign|Metabolic Syndrome Complexo Hospitalario Universitario de A Coruña July 10 2018 Not Applicable
NCT02824380 Completed Drug: DA-4001 H|Drug: DA-4001 L Androgenic Alopecia Dong-A ST Co. Ltd. July 2016 Phase 1
NCT02146937 Withdrawn Drug: Bicalutamide plus Finasteride- Combination therapy Detectable Prostate Nodules Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins March 2014 Phase 2
NCT01703520 Completed -- Male Breast Cancer Merck Sharp & Dohme Corp.|Institute for Applied Economics and Health Research Aps May 1 2011 --

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5-alpha Reductase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID