For research use only.
Catalog No.S1197 Synonyms: MK-906
Molecular Weight(MW): 372.54
Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
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Choose Selective 5-alpha Reductase Inhibitors
|Description||Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).|
Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 1.62 ms.  Finasteride dose-dependently inhibits the growth rate of the LnCap cell line.  Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells. 
|In vivo||Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. Finasteride also causes decreased anogenital distance in male offspring in male rats.  Finasteride and castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats. Finasteride-induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to control values by day 9 in rats. |
-  Azzolina B, et al. J Steroid Biochem Mol Biol, 1997, 61(1-2), 55-64.
-  Bologna M, et al. Urology, 1995, 45(2), 282-290.
-  Wang LG, et al. Cancer Res, 1997, 57(4), 714-719.
|In vitro||DMSO||75 mg/mL (201.32 mM)|
|Ethanol||75 mg/mL (201.32 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04288427||Not yet recruiting||Drug: Finasteride||Benign Prostatic Hyperplasia|Prostate Hyperplasia|Prostate Disease|Prostate Hypertrophy|Prostate Pain|Lower Urinary Tract Symptoms|Urinary Obstruction|Urinary Tract Disease||Beth Israel Deaconess Medical Center||April 2020||Not Applicable|
|NCT03669692||Recruiting||Behavioral: Caloric Restriction|Behavioral: Control||Prostatic Hyperplasia Benign|Metabolic Syndrome||Complexo Hospitalario Universitario de A Coruña||July 10 2018||Not Applicable|
|NCT02824380||Completed||Drug: DA-4001 H|Drug: DA-4001 L||Androgenic Alopecia||Dong-A ST Co. Ltd.||July 2016||Phase 1|
|NCT02146937||Withdrawn||Drug: Bicalutamide plus Finasteride- Combination therapy||Detectable Prostate Nodules||Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||March 2014||Phase 2|
|NCT01703520||Completed||--||Male Breast Cancer||Merck Sharp & Dohme Corp.|Institute for Applied Economics and Health Research Aps||May 1 2011||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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