WDR5

Other Methylation Related Inhibitors

EZH2 PRMT MAT2A LSD1 JMJD G9a/GLP SETD MLL COMT DOT1

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7833	OICR-9429	OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.	FASEB J, 2025, 39(8):e70543 Mol Cell, 2024, 84(8):1475-1495.e18 PLoS Biol, 2024, 22(3):e3002240
S2184	WDR5-0103	WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.	Protein Cell, 2025, 16(6):439-457 J Clin Invest, 2023, 133(13)e169993 Cancer Res, 2023, 83(16):2750-2762

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7833

OICR-9429

OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.

FASEB J, 2025, 39(8):e70543

Mol Cell, 2024, 84(8):1475-1495.e18

PLoS Biol, 2024, 22(3):e3002240

S2184

WDR5-0103

WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.

Protein Cell, 2025, 16(6):439-457

J Clin Invest, 2023, 133(13)e169993

Cancer Res, 2023, 83(16):2750-2762