WDR5

Other Methylation Related Inhibitors

EZH2 PRMT MAT2A LSD1 JMJD G9a/GLP SETD MLL COMT DOT1

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7833	OICR-9429	OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.	Journal of Experimental & Clinical Cancer Research, June 21, 2021, 203 iScience, December 25, 2021, 103679 FASEB Journal, April 30, 2025, e70543
S2184	WDR5-0103	WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.	Cell Reports, September 26, 2023, 113145 Journal of Clinical Investigation, July 3, 2023, e169993 Frontiers in Immunology, August 9, 2022, 938944

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7833

OICR-9429

OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.

Journal of Experimental & Clinical Cancer Research, June 21, 2021, 203

iScience, December 25, 2021, 103679

FASEB Journal, April 30, 2025, e70543

S2184

WDR5-0103

WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.

Cell Reports, September 26, 2023, 113145

Journal of Clinical Investigation, July 3, 2023, e169993

Frontiers in Immunology, August 9, 2022, 938944