- γ secretase
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM.
|Pan||γ secretase (cell-based), IC50: 0.082 nM; γ secretase (membrane-based), IC50: 0.078 nM|
YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
|Pan||γ secretase(APPL), IC50: 2.6 nM|
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
|Pan||γ secretase, IC50: 4 nM|
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