- γ secretase
- Aβ
- Notch
Notch Selective Inhibitors
Catalog No. | Product Name | Information | Selective / Pan | IC50 / Ki |
---|---|---|---|---|
S7399 | FLI-06 | FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
Selective | Notch, EC50: 2.3 μM |
S2714 | LY411575 | LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM. |
Pan | Notch S3 cleavage, IC50: 0.39 nM |
S2711 | YO-01027 (Dibenzazepine) | YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively. |
Pan | γ secretase(Notch), IC50: 2.9 nM |
S1575 | RO4929097 | RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2. |
Pan | γ secretase(ICN), IC50: 5 nM |
S1594 | Semagacestat (LY450139) | Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. Phase 3. |
Pan | Notch, IC50: 14.1 nM |