γGCS

Cat.No. Product Name Information Product Use Citations Product Validations
S9728 L-Buthionine-(S,R)-sulfoximine (L-BSO) BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
Nat Metab, 2026, 8(4):840-854
Redox Biol, 2024, 70:103039
Cancer Letters, 2024, 217258