γGCS

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Catalog No. Product Name Information Product Use Citations Product Validations
S9728 BSO (L-Buthionine-(S,R)-sulfoximine)

BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

Proc Natl Acad Sci U S A, 2021, 118(7)e2021342118
Redox Biol, 2021, S2213-2317(21)00076-8
S9728 BSO (L-Buthionine-(S,R)-sulfoximine)

BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

Proc Natl Acad Sci U S A, 2021, 118(7)e2021342118
Redox Biol, 2021, S2213-2317(21)00076-8