γGCS

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S9728	L-Buthionine-(S,R)-sulfoximine (L-BSO)	BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.	Redox Biol, 2024, 70:103039 Cancer Lett, 2024, 604:217258 Cell Death Dis, 2024, 15(3):182

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S9728

L-Buthionine-(S,R)-sulfoximine (L-BSO)

BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

Redox Biol, 2024, 70:103039

Cancer Lett, 2024, 604:217258

Cell Death Dis, 2024, 15(3):182