Stenabolic (SR9009)

Catalog No.S8692

For research use only.

Stenabolic (SR9009) is a synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.

Stenabolic (SR9009) Chemical Structure

CAS No. 1379686-30-2

Selleck's Stenabolic (SR9009) has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Stenabolic (SR9009) is a synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.
REV-ERB-α [1]
(HEK293 cells)
REV-ERB-β [1]
(HEK293 cells)
670 nM 800 nM
In vitro

SR9009 specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues. The regulation of autophagy and de novo lipogenesis by SR9009 has a critical role in evoking an apoptotic response in malignant cells. The impairment of cancer cell viability on treatment with SR9009 is due to induction of apoptosis, as assessed by cleaved caspase 3 and terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labelling (TUNEL) assay. SR9009 could reduce the number of autophagosomes and may inhibit autophagy[2].

In vivo SR9009 treatment results in a decrease in fat mass and in plasma lipids in diet-induced obese mice[1]. The treatment impairs glioblastoma growth in vivo and improve survival without causing overt toxicity in mice. SR9009 is known to cross the blood-brain barrier and reduce tumour growth in a xenograft model of a patient-derived glioblastoma. It effectively and significantly improved survival in two glioblastoma models[2].

Protocol (from reference)

Cell Research:


  • Cell lines: Jurkat cell
  • Concentrations: 20 μM
  • Incubation Time: 72 h
  • Method:

    Cell viability assay

Animal Research:


  • Animal Models: male C57BL/6 mice (8-10 weeks of age)
  • Dosages: 100 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 437.94


CAS No. 1379686-30-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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