Loxapine

Catalog No.S5197 Synonyms: Adasuve

For research use only.

Loxapine (Adasuve), a typical neuroleptic, is a drug with D2/D3 receptor antagonist activity and a higher affinity for D3 than D2. Loxapine displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.

Loxapine Chemical Structure

CAS No. 1977-10-2

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Biological Activity

Description Loxapine (Adasuve), a typical neuroleptic, is a drug with D2/D3 receptor antagonist activity and a higher affinity for D3 than D2. Loxapine displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.
Targets
dopamine D2 receptor [1]
()
dopamine D3 receptor [1]
()
dopamine D4 receptor [2]
()
serotonin 5-HT2 receptor [2]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 66 mg/mL
(201.33 mM)
Water Insoluble
Ethanol ''66 mg/mL

Chemical Information

Molecular Weight 327.81
Formula

C18H18ClN3O

CAS No. 1977-10-2
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02525991 Completed Device: Staccato® Delivery System Loxapine (ADASUVE®) Agitation Ferrer Internacional S.A. September 8 2016 Phase 4
NCT02820519 Terminated Drug: Loxapine Neuropathic Pain University of Witten/Herdecke June 2016 Phase 2
NCT03513549 Recruiting Drug: Loxapine 10 MG AgitationPsychomotor Alexza Pharmaceuticals Inc.|Pharmaceutical Research Associates November 4 2014 --
NCT02184767 Completed Drug: ADASUVE® BiPolar Teva Branded Pharmaceutical Products R&D Inc. July 2014 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

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