Lasmiditan

Catalog No.S5064 Synonyms: Reyvow

For research use only.

Lasmiditan (Reyvow) is a highly selective 5-hydroxytryptamine (serotonin) receptor 1F (5-HT1F) agonist that can be used as a promising acute anti-migraine therapy.

Lasmiditan Chemical Structure

CAS No. 439239-90-4

Purity & Quality Control

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Biological Activity

Description Lasmiditan (Reyvow) is a highly selective 5-hydroxytryptamine (serotonin) receptor 1F (5-HT1F) agonist that can be used as a promising acute anti-migraine therapy.
Targets
5-HT1F [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 75 mg/mL
(198.74 mM)
Water Insoluble
Ethanol ''75 mg/mL

Chemical Information

Molecular Weight 377.36
Formula

C19H18F3N3O2

CAS No. 439239-90-4
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04881747 Completed Drug: Lasmiditan Healthy Eli Lilly and Company May 14 2021 Phase 1
NCT04081324 Completed Drug: Lasmiditan|Drug: Placebo Healthy Eli Lilly and Company November 13 2019 Phase 1
NCT03988088 Completed Drug: Lasmiditan Migraine Eli Lilly and Company July 22 2019 Phase 1
NCT03962738 Completed Drug: Lasmiditan|Drug: Placebo Migraine Eli Lilly and Company May 31 2019 Phase 2
NCT03579940 Completed Drug: Lasmiditan|Drug: Placebo Healthy Eli Lilly and Company June 27 2018 Phase 1
NCT03459612 Completed Drug: Lasmiditan|Drug: Placebo|Drug: Diphenhydramine Healthy Eli Lilly and Company March 26 2018 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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