Ferrostatin-1 (Fer-1)

For research use only.

Catalog No.S7243

76 publications

Ferrostatin-1 (Fer-1) Chemical Structure

CAS No. 347174-05-4

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.

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Selleck's Ferrostatin-1 (Fer-1) has been cited by 76 publications

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Choose Selective Ferroptosis Inhibitors

Biological Activity

Description Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
Ferroptosis [1]
(HT-1080 cells)
60 nM(EC50)
In vitro

Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human IMR32 neuroblastoma cells NYHrTnVrTnWwY4Tpc44h[XO|YYm= MWexN{Bp Mn31RY51cW[ncoLvdJRwfGmlIHHjeIl3cXS7IHnuJIh2dWGwIFnNVlMzKG6ndYLvZoxie3SxbXGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCncnHzeIlvNWmwZIXj[YQh[2WubDDk[YF1cCCycnXpcoN2[mG2ZXSg[o9zKDFiaIKgZoVnd3KnIHXyZZN1cW5ic4TpcZVt[XSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE{KGi{czDifUBndHWxcnXzZ4Vv[2VicHzheIUhemWjZHXyJI1mfGixZDygTWM2OD1yLkCxPEDPxE1? NIDkemEzPjZ7NkCxOC=>
HT1080 cells MlPmSpVv[3Srb36gZZN{[Xl? M33UVWFvfGmoZYLyc5B1d3SrYzDhZ5Rqfmm2eTDpckBpfW2jbjDIWFExQDBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBmemG|dHnuMYlv\HWlZXSgZ4VtdCCmZXH0bEBjgSCDbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0xNjB7NTFOwG0> MlHRNlY3QTZyMUS=
HRE cells MYLD[YxtKH[rYXLpcIl1gSCjc4PhfS=> MkDkNUDPxE1? M2rvOVQ5NTd{IHjveZJ{ MkXITY5lfWO2aX;uJI9nKGOnbHygZZBweHSxc3nz MYCzNFc6PDZ6Mh?=
U57810 and C2C12 cells NXvYfFZbS2WubDD2bYFjcWyrdImgZZN{[Xl? M33LflExKM7:TR?= M2P5NFI1NCB2ODygZY5lKDd{IHi= MXzB[I1qdmm|dILheIlwdiCxZjDm[ZJzd3O2YYTpck0yKGGubX;zeEBkd22ybHX0[Yx6KHC{ZY\lcpRm\CC2aHWg[oVzem:ydH;0bYMh[2WubDDk[YF1cC5? Ml3lNlk6PzF3M{K=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 52 mg/mL (198.2 mM)
Ethanol 52 mg/mL (198.2 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+50% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 262.35


CAS No. 347174-05-4
Storage powder
in solvent
Synonyms N/A
Smiles CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID