For research use only.

Catalog No.S2832 Synonyms: 3β-androsterone, EpiA

Epiandrosterone Chemical Structure

CAS No. 481-29-8

Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.

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10mM (1mL in DMSO) USD 350 In stock
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Biological Activity

Description Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.
AR [1] ER [1]
In vitro

Epiandrosterone is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductaseenzyme. Epiandrosterone is formed in peripheral tissues, from which it is released into the circulation and is ultimately excreted in the urine. Epiandrosterone is only a weak androgen, but it is widely recognized to inhibit the pentose phosphate pathway (PPP) and to decrease intracellular NADPH levels. [1] Epiandrosterone attenuates NO-evoked relaxation of pulmonary artery [2], although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCl. [3]


Solubility (25°C)

In vitro Ethanol 58 mg/mL (199.69 mM)
DMSO 29 mg/mL warmed (99.84 mM)
Water Insoluble

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Chemical Information

Molecular Weight 290.44


CAS No. 481-29-8
Storage powder
in solvent
Synonyms 3β-androsterone, EpiA

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00924469 Completed Drug: Abiraterone|Drug: Leuprolide|Drug: Prednisone Prostate Cancer Janssen Research & Development LLC November 2009 Phase 2

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Androgen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID