Molecular Weight(MW): 561.44
Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays.
Purity & Quality Control
Choose Selective ALK Inhibitors
|Description||Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays.|
Ensartinib is a novel, potent anaplastic lymphoma kinase (ALK) small molecule tyrosine kinase inhibitor (TKI) with additional activity against MET, ABL, Axl, EPHA2, LTK, ROS1 and SLK. ALK autophosphorylation is significantly diminished by X-396, albeit at higher concentrations required to block autophosphorylation of the wild-type fusion.
|In vivo||X-396 displays potent anti-tumor activity in vivo with favorable pharmacokinetic and toxicity profiles. X-396 shows substantial bioavailability and moderate half-lives in vivo. It significantly delays the growth of tumors compared to vehicle alone. X-396 could lead to higher efficacy against ALK-fusion positive brain metastases. It has demonstrated significant pre-clinical anti-tumor activity in both ALK TKI-naïve and crizotinib-resistant models of ALK rearranged NSCLC.|
|In vitro||DMSO||100 mg/mL (178.11 mM)|
|Ethanol||100 mg/mL (178.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03536481||Not yet recruiting||Lung Cancer||Betta Pharmaceuticals Co.Ltd.||May 31 2018||Phase 1|
|NCT03215693||Recruiting||Non-Small Cell Lung Cancer||Betta Pharmaceuticals Co.Ltd.||September 28 2017||Phase 2|
|NCT03213652||Recruiting||Advanced Malignant Solid Neoplasm|ALK Fusion Protein Expression|ALK Gene Mutation|ALK Gene Translocation|Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma|Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma|Histiocytosis|Recurrent Childhood Central Nervous System Neoplasm|Recurrent Childhood Non-Hodgkin Lymphoma|Recurrent Malignant Solid Neoplasm|Recurrent Neuroblastoma|Refractory Central Nervous System Neoplasm|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|ROS1 Fusion Positive|ROS1 Gene Mutation|ROS1 Gene Translocation||National Cancer Institute (NCI)||July 24 2017||Phase 2|
|NCT02959619||Recruiting||Solid Tumor|Non-Small Cell Lung Cancer Metastatic||Betta Pharmaceuticals Co.Ltd.||November 2016||Phase 1|
|NCT02767804||Recruiting||Non-small Cell Lung Cancer||Xcovery Holding Company LLC||June 2016||Phase 3|
|NCT01625234||Recruiting||Advanced Solid Tumors|Non-small Cell Lung Cancer||Xcovery Holding Company LLC||June 2012||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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