Molecular Weight(MW): 561.44
Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays.
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Choose Selective ALK Inhibitors
|Description||Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays.|
Ensartinib is a novel, potent anaplastic lymphoma kinase (ALK) small molecule tyrosine kinase inhibitor (TKI) with additional activity against MET, ABL, Axl, EPHA2, LTK, ROS1 and SLK. ALK autophosphorylation is significantly diminished by X-396, albeit at higher concentrations required to block autophosphorylation of the wild-type fusion.
|In vivo||X-396 displays potent anti-tumor activity in vivo with favorable pharmacokinetic and toxicity profiles. X-396 shows substantial bioavailability and moderate half-lives in vivo. It significantly delays the growth of tumors compared to vehicle alone. X-396 could lead to higher efficacy against ALK-fusion positive brain metastases. It has demonstrated significant pre-clinical anti-tumor activity in both ALK TKI-naïve and crizotinib-resistant models of ALK rearranged NSCLC.|
|In vitro||DMSO||100 mg/mL (178.11 mM)|
|Ethanol||100 mg/mL (178.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03737994||Not yet recruiting||ALK Gene Rearrangement|ALK Positive|Non-Squamous Non-Small Cell Lung Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8||National Cancer Institute (NCI)||January 13 2019||Phase 2|
|NCT03574402||Not yet recruiting||Carcinoma Non-Small-Cell Lung||Guangdong Association of Clinical Trials||July 1 2018||Phase 2|
|NCT03608007||Recruiting||Lung Cancer|ROS1 Gene Rearrangement||Betta Pharmaceuticals Co.Ltd.||June 15 2018||Phase 2|
|NCT03536481||Not yet recruiting||Lung Cancer||Betta Pharmaceuticals Co.Ltd.||May 31 2018||Phase 1|
|NCT03510611||Enrolling by invitation||Non-Small Cell Lung Cancer||Betta Pharmaceuticals Co.Ltd.||March 19 2018||Phase 1|
|NCT03420508||Recruiting||Melanoma||Memorial Sloan Kettering Cancer Center|Xcovery Holding Company LLC||January 10 2018||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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