Catalog No.S4757 Synonyms: androstanolone, stanolone, 5α-DHT
Molecular Weight(MW): 290.44
Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.
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|Description||Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.|
In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells.
|In vivo||DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan.|
|In vitro||DMSO||58 mg/mL (199.69 mM)|
|Ethanol||58 mg/mL (199.69 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||androstanolone, stanolone, 5α-DHT|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04032067||Not yet recruiting||Drug: GV1001 placebo|Drug: Proscar placebo||Benign Prostatic Hyperplasia (BPH)||GemVax & Kael||August 28 2019||Phase 3|
|NCT03361969||Recruiting||Drug: Estetrol|Drug: Placebo Oral Tablet||Prostatic Neoplasm||Pantarhei Oncology B.V.||April 16 2018||Phase 2|
|NCT03314298||Completed||Drug: testosterone anastrozole||Mammographic Density||Havah Therapeutics Pty Ltd||August 14 2017||Phase 1|
|NCT02574910||Recruiting||Drug: Abiraterone acetate||Congenital Adrenal Hyperplasia||University of Texas Southwestern Medical Center|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|University of Michigan|Children''s Hospital Los Angeles||August 1 2017||Phase 1|
|NCT03085095||Recruiting||Drug: Relugolix|Drug: Leuprolide Acetate||Prostate Cancer||Myovant Sciences GmbH||April 18 2017||Phase 3|
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