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Dihydrotestosterone (DHT)
Catalog No.S4757 Synonyms: androstanolone, stanolone, 5α-DHT
For research use only.
Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.
CAS No. 521-18-6
Selleck's Dihydrotestosterone (DHT) has been cited by 17 publications
Purity & Quality Control
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Biological Activity
| Description | Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells[1]. |
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| Cell Data |
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| Assay |
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| In vivo | DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan[2]. |
Protocol (from reference)
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Solubility (25°C)
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Chemical Information
| Molecular Weight | 290.44 | ||
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| Formula | C19H30O2 |
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| CAS No. | 521-18-6 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C | ||
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04989972 | Withdrawn | Drug: PSIL428|Dietary Supplement: Oyster mushroom | Anxiety and Depression | Wake Network Inc.|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI | September 15 2022 | Phase 2 |
| NCT05033444 | Recruiting | Drug: PRV-002|Drug: Placebo | Traumatic Brain Injury (TBI) | Odyssey Group International Inc.|Avance Clinical Pty Ltd. | September 17 2021 | Phase 1 |
| NCT05042895 | Recruiting | Procedure: Group A|Procedure: Group B | Infertility | Woman''s Health University Hospital Egypt | August 20 2021 | Not Applicable |
(data from https://clinicaltrials.gov, updated on 2022-08-01)
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