Dihydrotestosterone (DHT)

Name: Dihydrotestosterone (DHT)
Brand: Selleck Chemicals
SKU: S4757
Rating: 5 (8 reviews)

For research use only.

Catalog No.S4757 Synonyms: androstanolone, stanolone, 5α-DHT

8 publications

Dihydrotestosterone (DHT) Chemical Structure

CAS No. 521-18-6

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

Selleck's Dihydrotestosterone (DHT) has been cited by 8 publications

Environ Health Perspect, 2021, 129(4):47010

PubMed: 33851871 ( click the link to review the publication )

Sci Rep, 2021, 11(1):14880

PubMed: 34290270 ( click the link to review the publication )

Prostate, 2021, 81(9):508-520

PubMed: 33955576 ( click the link to review the publication )

Hum Reprod, 2020, 6 pii: deaa077

PubMed: 32372097 ( click the link to review the publication )

Prostate, 2020, 80(9):674-686

PubMed: 32294305 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 21;526(1):267-272

PubMed: 32209261 ( click the link to review the publication )

Onco Targets Ther, 2020, 13:9821-9837

PubMed: 33061460 ( click the link to review the publication )

Circulation, 2019, 140(13):1070-1080

PubMed: 31378084 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Androgen Receptor Inhibitors

Biological Activity

Description

Targets

Androgen Receptor ^[1]
()

In vitro

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells^[1].

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
CV-1 cell	MoTzSpVv[3Srb36gZZN{[Xl?			NXzlbYpjSWexbnnzeIlkKGGldHn2bZR6KCiHQ{WwLUBi\2GrboP0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXi1zIHPlcIwtKEWFNUC9NE4xODZizszN	M3Wwd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{G1N\|QoRjl6N{G1N\|Q9N2F-
MDA-MB-453 cell	Ml\3SpVv[3Srb36gZZN{[Xl?			M3TDSmRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKE2GQT3NRk01PTNiY3XscJMh[nlid3jvcIUh[2WubDDy[YNmeHSxcjDibY5lcW6pIHHzd4F6NCCNaU2wMlAxODJizszN	M4\ZXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEO0NVE4Lz5zN{CzOFEyPzxxYU6=
HepG2 cell	NHnl[pRHfW6ldHnvckBie3OjeR?=			MWDBZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGGwZILv[4VvKHKnY3XweI9zKGW6cILld5Nm\CCrbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[WO2aY\heIlwdixiSVO1NF0xNjBzOEKg{txO	M{LySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUS5PFY3Lz5zN{G0PVg3PjxxYU6=
MDA453 cell	MVjGeY5kfGmxbjDhd5NigQ>?			M4TNOWRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gRXIhcW5iTVTBOFU{KGOnbHzzMEBMcT1yLkCwN{DPxE1?	NVjiWZRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPDFpPkG3NVgyOTRzPD;hQi=>
mouse C2C12 cell	NHnFUHRHfW6ldHnvckBie3OjeR?=			NUe5UmRSSWexbnnzeEBi[3Srdnn0fUBifCC{YYSgRXIhfHKjboPm[YN1\WRiaX6gcY92e2ViQ{LDNVIh[2WubIOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiC2cnHud4FkfGm4YYTpc44h[XO\|YYmsJGVEPTB;MD6wNlgh\|ryP	NXTOT\|FFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPDFpPkG3NVgyOTRzPD;hQi=>
monkey COS7 cell	MXvGeY5kfGmxbjDhd5NigQ>?			MXvCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBud26tZYmgR29UPyClZXzsd{BjgSC5aH;s[UBk\WyuIHLpcoRqdmdiYYPzZZktKEurPUCuNFAxOiEQvF2=	M4TzZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESyPVEzLz5zOES0NlkyOjxxYU6=
CHO cell	M4rlW2Z2dmO2aX;uJIF{e2G7			M3XDZ2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gWGdTPSCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEWFNUC9OE41QSEQvF2=	NEj1d3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwO\|I6PCd-MUizNFczQTR:L3G+
COS7 cell	MkjLSpVv[3Srb36gZZN{[Xl?			M2P4S2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgW\|c1OUNibYX0ZY51KGW6cILld5Nm\CCrbjDDU3M4KGOnbHzzJIF{e2W\|c3XkJIF{KGy3Y3nm[ZJie2ViYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMUKg{txO	MnvxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
COS7 cell	M{\1d2Z2dmO2aX;uJIF{e2G7			NVHERWh5SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBVQDd5QTDteZRidnRiZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[XO\|ZYPz[YQh[XNibIXjbYZmemG\|ZTDhZ5Rqfmm2eTDh[pRmeiB{NDDodpMh[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCxOUDPxE1?	NWXvd4J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPVQzPzlpPkKyNFk1Ojd7PD;hQi=>
COS7 cell	MoqxSpVv[3Srb36gZZN{[Xl?			MnmyRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS0:VNzDj[YxteyCjc4Pld5Nm\CCjczDseYNq\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyCkeTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBGSzVyPUCuNFA3OiEQvF2=	NXjJbHRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPVQzPzlpPkKyNFk1Ojd7PD;hQi=>
LNCaP-hr cell	MYnGeY5kfGmxbjDhd5NigQ>?		MlvIN{Bl[Xm\|	NUTvcVdoSWexbnnzeEBi[3Srdnn0fUBifCCDbnTyc4dmdiC{ZXPldJRweiCWOEe3RUBufXSjboSgbY4hcHWvYX6gUG5E[VBvaIKgZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwe3SjdHWgd5Bm[2moaXOgZY51cWenbjDz[YNz\XSrb36gcYVie3W{ZXSgZYZ1\XJiMzDkZZl{KGK7IHXufplu\S2rbX31co9ie3OjeTygSWM2OD1yLkCxOUDPxE1?	M1P0T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
LNCaP-hr cell	NV7uR3U6TnWwY4Tpc44h[XO\|YYm=		NF61emo{KGSjeYO=	M{PKOmFod26rc4SgZYN1cX[rdImgZZQhf2muZDD0fZBmKEGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKEyQQ3HQMYhzKGOnbHzzJIF{e2W\|c3XkJIF{KHC{b4P0ZZRmKHOyZXPp[olkKGGwdHnn[Y4he2WlcnX0bY9vKG2nYYP1doVlKGGodHXyJFMh\GG7czDifUBmdnq7bXWtbY1ufW6xYYPzZZktKEWFNUC9NE4xODZ{IN88US=>	Mmn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOUm0O\|coRjJ\|MUm5OFc4RC:jPh?=
HEK293 cell	MmL4SpVv[3Srb36gZZN{[Xl?			NEnkWG9C\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR\|UxRTBwMUigcm0>	M1TCRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1Olg5Lz5{NUOwOVY5QDxxYU6=
COS	M4L3V2Z2dmO2aX;uJIF{e2G7			NUDCeWFFSmmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JGFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBEV1NiY3XscJMtKEurIE2gNE4xODJizszNMi=>	Ml;sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5MUWzOEc,QTh5MUWzOFww[T5?
COS-1	MWjGeY5kfGmxbjDhd5NigQ>?			NVjSV5ozSmmwZHnu[{Bi\m[rbnn0fUBnd3JiaIXtZY4hSW6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPPV{0yKGOnbHzzMEBMcSB;IECuNFA{KM7:TT6=	NXvjb\|BlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUmyOVczPSd-OUmyOVczPTxxYU6=
CV-1	M{PKdWZ2dmO2aX;uJIF{e2G7			NI[zNGtC\2:waYP0JIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXNTFiY3XscJMtKEWFNUCgQUAxNjByNTFOwG0v	MoCwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl{NUeyOUc,QTl{NUeyOVww[T5?
COS	NETCPWdHfW6ldHnvckBie3OjeR?=			NVHvOItJUW5idnn0do8h[mmwZHnu[{Bi\m[rbnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkB1emGwc3\lZ5Rm\CCrboTvJGNQWyClZXzsd{4tKEmFNUCgQUAxNjByNDFOwG0v	M2jqZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMkOwOlI5Lz5zMEKzNFYzQDxxYU6=
CV-1	MWrGeY5kfGmxbjDhd5NigQ>?			NWTlUFFUUW5idnn0do8h[WexbnnzeIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgeZNqdmdiY3;0doFve2[nY4Tpc44h[XO\|YYmgbY4hS1ZvMTDj[Yxtey5uIFXDOVAhRSByLkCwOkDPxE1w	M1fac\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMkOwOlI5Lz5zMEKzNFYzQDxxYU6=
CV-1	MVTGeY5kfGmxbjDhd5NigQ>?			NV7OfmtESWexbnnzeEBi[3Srdnn0fUB1dyC2aHWgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiKHjBVkkhcW5iQ2[tNUBk\WyuczygSWM2OCB;IECuNFA3KM7:TT6=	NX;rSXV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFA3OjRpPkGwN\|QxPjJ2PD;hQi=>
CV1	NWTaVnBGTnWwY4Tpc44h[XO\|YYm=			NWSxSXpMSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBqdiCFVkGgZ4VtdHNibXXhd5Vz\WRiYYOgd5RqdXWuYYTpc44hd2ZibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGGldHn2bZR6KGK7IHPveJJidnOoZXP0bY9vKGG\|c3H5MEBGSzVyIE2gNE4xODVzIN88UU4>	NFjPcFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CzOFEyPyd-MUewN\|QyOTd:L3G+
CV1	MnXGSpVv[3Srb36gZZN{[Xl?			NVT5PY1uSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy\|LDDLbUA:KDBwMECwNkDPxE1w	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3N{izPEc,OTd{NUe4N\|g9N2F-
CV1	M4m2SmZ2dmO2aX;uJIF{e2G7			M1nkZ2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEOYMTDj[YxteyxiRVO1NEA:KDBwMEC1NUDPxE1w	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3N{izPEc,OTd{NUe4N\|g9N2F-
MDA-MB-453	MkPpSpVv[3Srb36gZZN{[Xl?			MV;EbZNxdGGlZX3lcpQhd2ZiW{PIYWRJXCCocn;tJIh2dWGwIFHSJIV5eHKnc4Pl[EBqdiCPRFGtUWIuPDV\|IHPlcIx{NCCNaTC9JFAvODByMzFOwG0v	NWfpbYhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N\|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1	NH20VFBHfW6ldHnvckBie3OjeR?=			M2HUcWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w	MmfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{mxNVIoRjF5NEO5NVEzRC:jPh?=
CV1	MUXGeY5kfGmxbjDhd5NigQ>?			MUHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMh[nlidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYYPzZZktKEWFNUCgQUAxNjByNUeg{txONg>?	NFf1Rnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewN\|k{QCd-MUe3NFM6Ozh:L3G+
MDA-MB-453	MXfGeY5kfGmxbjDhd5NigQ>?			M3K4[GRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gRY5lem:pZX6gdoVk\XC2b4KgbY4hcHWvYX6gUWRCNU2ELUS1N{Bk\WyuczygT4khRSByLkCwNFkh\|ryPLh?=	MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MEC0PVkoRjF6NECwOFk6RC:jPh?=
CV1	NHPzZ\|VHfW6ldHnvckBie3OjeR?=			M3yzTWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgbY4hS1ZzIHPlcIx{KGK7IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5yMEW3JO69VS5?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRyMES5PUc,OTh2MEC0PVk9N2F-
Saos2	MlPZSpVv[3Srb36gZZN{[Xl?			M1LNS2FkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKFOjb4OyJINmdGy\|IHHzd4V{e2WmIHHzJGlNPiC{ZYDy[ZN{cW:wLDDJR\|UxKD1iMD6wNFAxPSEQvF2u	M1TGc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESyPVEzLz5zOES0NlkyOjxxYU6=
CV1	M1X3Z2Z2dmO2aX;uJIF{e2G7			MYrB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNXOSClZXzsd{BjgSClb4TyZY5{\mWldHnvckBie3OjeTygSWM2OCB;IECuNFA2OSEQvF2u	NF\TWFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0NlkyOid-MUi0OFI6OTJ:L3G+
MDA-kb2	M4XESGZ2dmO2aX;uJIF{e2G7			NF21OotC\2:waYP0JIFkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKE2GQT3rZlIh[2WubIOgZZN{\XO\|ZXSgZZMhe3SrbYXsZZRqd25ib3[gcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGVEOTVyIE2gNE4xODB3IN88UU4>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7MkK0OUc,OTl3OUKyOFU9N2F-
MDA-kb2	M2L4XGZ2dmO2aX;uJIF{e2G7			M1G3OGFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gUWRCNWukMjDj[YxteyCjc4Pld5Nm\CCjczDzeIlufWyjdHnvckBw\iCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVOxOVAhRSByLkCwNFUh\|ryPLh?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7MkK0OUc,OTl3OUKyOFU9N2F-
MDA-MB-453	NXnOW\|RKTnWwY4Tpc44h[XO\|YYm=			NIey[VFFcXOybHHj[Y1mdnRib3[gX\|NJZW2ndHj5cJRzcWWwb3zvcoUh\nKxbTDhcoRzd2enbjDy[YNmeHSxcjDpckBpfW2jbjDNSGEuVUJvNEWzJINmdGy\|LDDJR\|UxKD1iMD6wNFEh\|ryPLh?=	M1TqRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkC2PFcxLz5zOU[wOlg4ODxxYU6=
MDA-MB-453	Mk\oSpVv[3Srb36gZZN{[Xl?			NYr4PGp5SWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtUWIuPDV\|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghVU2WVj3MWWMh[XO\|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJG1OXFZvTGTSM5Bzd22xdHXyJIxqdmunZDDMWWMh\2WwZTDifUBtfWOrZnXyZZNmKHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OCB;IECuNFAzKM7:TT6=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZyNki3NEc,OTl4ME[4O\|A9N2F-
NIH3T3	MUDGeY5kfGmxbjDhd5NigQ>?			Mn\iRYdwdmm\|dDDhZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBNSkRiVEi3O2EhdXW2YX70JIlvKG2xdYPlJG5KUDOWMzDj[YxteyC2cnHud4lmdnSueTD0doFve2[nY4Tl[EB4cXSqIHLleIEu\2GuYXP0c5Nq\GG\|ZTDy[ZBwenSncjDn[Y5mKGG\|c3Xzd4VlKGG\|IHPlcIx2dGG{IITyZY5{\m:{bXH0bY9vKGK7IGKtV2FVKGG\|c3H5MEBGSzVyIE2gNE4xODF{NUmg{txONg>?	Mn[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NU[5NlEoRjF7OEW2PVIyRC:jPh?=
NIH3T3	M4rs[GZ2dmO2aX;uJIF{e2G7			Ml3MRYdwdmm\|dDDhZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCvb4Xz[UBPUUh\|VEOgZ4VtdHNidILhcpNq\W62bImgeJJidnOoZXP0[YQhf2m2aDDi[ZRiNWejbHHjeI9{cWSjc3WgdoVxd3K2ZYKg[4Vv\SCjc4Pld5Nm\CCjczDj[YxtfWyjcjD0doFve2[xcn3heIlwdiCkeTDSMXNCXCCjc4PhfUwhTUN3MDC9JFAvODB\|OUixJO69VS5?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh3NkmyNUc,OTl6NU[5NlE9N2F-
COS7	M4DKUmZ2dmO2aX;uJIF{e2G7			NVXleHVRSWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCuaXfhcoQh[mmwZHnu[{Bld22jaX6g[ZhxemW\|c3XkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IFPPV\|ch[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBI[Wx2LVTCSEBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGVEPTBiPTCwMlAzKM7:TT6=	NIXBOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi2N\|A5Oyd-MUm4OlMxQDN:L3G+
Freestyle293F	NGrvRVhHfW6ldHnvckBie3OjeR?=		NF3sPJM{KGi{cx?=	NXTEWJhmTGm\|cHzhZ4Vu\W62IH;mJHsyPy2jbIDoZU1u\XSqeXytN2heNW2rYn;s[ZJwdmViZoLvcUBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJIRmemm4ZXSgSpJm\VO2eXzlNlk{TiClZXzsd{Bi\nSncjCzJIhzeyxiSVO1NEA:KDBwMECyNUDPxE1w	Ml60QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
Freestyle293F	NXXFVVdtTnWwY4Tpc44h[XO\|YYm=		MX6zJIhzew>?	M3HRSGRqe3CuYXPlcYVvfCCxZjDbNVcu[WyyaHGtcYV1cHmuLUPIYU1ucWKxbHXyc45mKG[{b32gbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiVEi3O2EhdXW2YX70JIV5eHKnc4Pl[EBqdiCKRVuyPVMh\GW{aY\l[EBHemWnU4T5cIUzQTOIIHPlcIx{KGGodHXyJFMhcHK\|LDDJR\|UxKD1iMD6wNFI3KM7:TT6=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB7NEK3PUc,OjJyOUSyO\|k9N2F-
HeLa	MoK1SpVv[3Srb36gZZN{[Xl?			MYfUdoFve2GldHn2ZZRqd25ib3[gbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JidILhcpNn\WO2ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGFkfGm4aYT5JF0hOC5yMEig{txONg>?	MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6OUe2NVEoRjJ{OEm3OlEyRC:jPh?=
HeLa	NYD1N2ZETnWwY4Tpc44h[XO\|YYm=			NFO2VJFR[XK2aXHsJIFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEinTHGgZ4VtdHNiY3:t[ZhxemW\|c3nu[{BCWkViYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHLhd4VlKHS{YX7zZYN1cX[jdHnvckBie3OjeTygRYN1cX[rdImgQUAxNjByODFOwG0v	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3N{m0O{c,OjJ7NUe5OFc9N2F-
Freestyle293F	NVn1NJFZTnWwY4Tpc44h[XO\|YYm=			M2PUOWlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFHu[JJw\2WwIILlZ4VxfG:{IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGZz\WW\|dIns[VI6O0ZiY3XscJMtKEmFNUCgQUAxNjByMkGg{txONg>?	M3LZclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
Freestyle293F	MnLhSpVv[3Srb36gZZN{[Xl?			MnvnTY5pcWKrdHnvckBw\iCDbnTyc4dmdiC{ZXPldJRweiCWOEe3RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hTnKnZYP0fYxmOjl\|RjDj[YxteyxiSVO1NEA:KDBwMECyOkDPxE1w	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF7OUS3O{c,OjNzOUm0O\|c9N2F-
COS7	MlvYSpVv[3Srb36gZZN{[Xl?		NI[wSVUzKGi{cx?=	MULEbZNxdGGlZX3lcpQhd2ZiW{PIYUBePWGucHjhMWRJXCCocn;tJI1wfXOnIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBud26tZYmgR29UPyClZXzsd{Bi\nSncjCyJIhzeyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oKGGwYXz5d4l{NCCLQ{WwJF0hOC5yMEGg{txONg>?	NXjxcGt[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1Nlc5OTZpPkKzOVI4QDF4PD;hQi=>
C2C12	Mo\YSpVv[3Srb36gZZN{[Xl?		MlPiOUBl[Xm\|	M{\6O2Fod26rc4SgZYN1cX[rdImgZZQh[W6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIH3veZNmKEN{Q{GyJINmdGy\|IHHzd4V{e2WmIHHzJI9{fGWxYnzhd5Qh\GmoZnXy[Y51cWG2aX;uJIFnfGW{IEWg[IF6eyxiRVO1NEA:KDBwMECwNFUh\|ryPLh?=	MoOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyPVAoRjJ2OUCwNlkxRC:jPh?=
C2C12	NGjuU5dHfW6ldHnvckBie3OjeR?=			MY\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBud3W\|ZTDDNmMyOiClZXzsd{BjgSCjbnTyc4dmdi2\|cHXjbYZq[yC{ZYPwc45{\SCnbHXt[Y51NWS{aY\lckBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkCwNFE{KM7:TT6=	NX7hU5I5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxNlE6PjRpPkK1NVIyQTZ2PD;hQi=>
COS7	MYnGeY5kfGmxbjDhd5NigQ>?		NELyfZUzPCCqcoO=	M1W4OWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gRXIh\XiycnXzd4VlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNQWzdiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMECzJO69VS5?	NHfBTmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1OFg1QSd-Mki0OVQ5PDl:L3G+
Shionogi	NV\DVXFkTnWwY4Tpc44h[XO\|YYm=	MlK5NVAheE1?		MlG0TY5lfWO2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhdW:3c3WgV4hqd26xZ3mgZ4VtdHNiYYSgNVAheE1?	M3m4e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{GxPFU2Lz5zN{exNVg2PTxxYU6=
MCF7	M2nsXGZ2dmO2aX;uJIF{e2G7	MkPsN\|AhfU1?	MnLRNlQhcHK\|	NWK0TnlDSW62YXfvcol{fCCjY4Tpeol1gSCjdDDBVkBqdiCqdX3hckBOS0Z5IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBCWiCuZY\lcEBifCB\|MDD1UUBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{KHKnbHH0bZZmKHSxIHPvcpRzd2x?	MnzkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMUS3OVEoRjJ{MEG0O\|UyRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h), and immunoblot analysis of cell lysates reveals that cyclin D1 and D2 protein expression decreased substantially with DHT treatment compared to vehicle. p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB ; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h). Immunoblot analysis of cell lysates reveals that CDK4 and CDK6 protein expression decreased and CDKN1A expression increased with DHT treatment compared to vehicle. CDK2 phosphorylation at threonine 160 (T160) decreased nearly 50% with androgen treatment at 24 and 48 hours, albeit not significantly, and total CDK2 protein expression remained unchanged. Relative to total RB expression, the levels of various phosphorylated forms of RB (S780 and S807/811) decreased over time with androgen treatment. p27 / p-p27 ; PubMed: 22139837 J Biol Chem CWR22Rv1 or CWR22R3 cells were stimulated with 10 nm DHT for 6 h, with the addition of MG132 during the last 2 h before harvesting. Proteins were then immunoblotted. AR / PP1 ; PubMed: 26636645 Oncotarget HeLa cells were transfected with Flag-PP1α and HA-AR and then incubated for overnight in androgen-depleted medium without or with androgen (10 nM of DHT) as indicated for blotting.	26372468 22139837 26636645
Immunofluorescence	FOXO1 / p27 ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with DHT (10 nm) for 4 h. The cells were immunostained for FOXO1 and p27 and examined with a confocal microscope. AKT(S473) / PKCα(S657) ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with 10 nm DHT (−/+ DHT) for 4 h. The cells were immunostained for AKT or PKCα phosphorylation and examined with a confocal microscope. Bars: 20 μm	22139837

In vivo

DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan^[2].

Protocol

Cell Research:

^[1]

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Cell lines: Bladder cancer cells
Concentrations: 1 nM
Incubation Time: 24 h
Method:
Bladder cancer cells at a density of 50-60% confluence in 24-well plates are co-transfected with 250 ng of MMTV-luc reporter plasmid DNA and 2.5 ng of PRL-TK-luc plasmid DNA. After 6 h of transfection, the medium is replaced with another medium supplemented with charcoal-stripped FBS in the presence or absence of ligands (DHT, HF, or both) for 24 h. Cells were harvested, lysed, and assayed for luciferase activity.

(Only for Reference)

Animal Research:

^[2]

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Animal Models: SOD1-G93A mutant mice with the congenic C57BL/6J background
Dosages: 5 mg
Administration: silastic implant
(Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	58 mg/mL (199.69 mM)
	Ethanol	58 mg/mL (199.69 mM)
	Water	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Dihydrotestosterone (DHT) SDF

Molecular Weight	290.44
Formula	C₁₉H₃₀O₂
CAS No.	521-18-6
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	androstanolone, stanolone, 5α-DHT
Smiles	CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

Serial Dilutions
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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05033444	Not yet recruiting	Drug: PRV-002\|Drug: Placebo	Traumatic Brain Injury (TBI)	Odyssey Group International Inc.\|Avance Clinical Pty Ltd.	September 2021	Phase 1
NCT04989972	Not yet recruiting	Drug: PSIL428\|Dietary Supplement: Oyster mushroom	Anxiety and Depression	Wake Network Inc.\|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI	September 15 2021	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Dihydrotestosterone (DHT)