Dihydrotestosterone (DHT)

Name: Dihydrotestosterone (DHT)
Brand: Selleck Chemicals
SKU: S4757
Rating: 5 (6 reviews)

For research use only.

Catalog No.S4757 Synonyms: androstanolone, stanolone, 5α-DHT

6 publications

Dihydrotestosterone (DHT) Chemical Structure

CAS No. 521-18-6

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

Selleck's Dihydrotestosterone (DHT) has been cited by 6 publications

Environ Health Perspect, 2021, 129(4):47010

PubMed: 33851871 ( click the link to review the publication )

Hum Reprod, 2020, 6 pii: deaa077

PubMed: 32372097 ( click the link to review the publication )

Prostate, 2020, 80(9):674-686

PubMed: 32294305 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 21;526(1):267-272

PubMed: 32209261 ( click the link to review the publication )

Onco Targets Ther, 2020, 13:9821-9837

PubMed: 33061460 ( click the link to review the publication )

Circulation, 2019, 140(13):1070-1080

PubMed: 31378084 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Androgen Receptor Inhibitors

Biological Activity

Description

Targets

Androgen Receptor ^[1]
()

In vitro

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells^[1].

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
CV-1 cell	M2nBUGZ2dmO2aX;uJIF{e2G7			NETEWJBC\2:waYP0bYMh[WO2aY\peJkhMEWFNUCpJIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXNTFiY3XscEwhTUN3ME2wMlAxPiEQvF2=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDdzNUO0K\|46QDdzNUO0QE9iRg>?
MDA-MB-453 cell	NHPyWZhHfW6ldHnvckBie3OjeR?=			M2LCPGRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKE2GQT3NRk01PTNiY3XscJMh[nlid3jvcIUh[2WubDDy[YNmeHSxcjDibY5lcW6pIHHzd4F6NCCNaU2wMlAxODJizszN	MkHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyM{SxNVcoRjF5MEO0NVE4RC:jPh?=
HepG2 cell	MoDnSpVv[3Srb36gZZN{[Xl?			M3rSNWFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhmeEd{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjY4TpeoF1cW:wLDDJR\|UxRTBwMEG4NkDPxE1?	M{DwSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUS5PFY3Lz5zN{G0PVg3PjxxYU6=
MDA453 cell	M{fjPWZ2dmO2aX;uJIF{e2G7			NVrpU3NmTGm\|cHzhZ4Vu\W62IH;mJHs{UF2GSGSg[pJwdSCqdX3hckBCWiCrbjDNSGE1PTNiY3XscJMtKEurPUCuNFA{KM7:TR?=	NIfZdYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE1OSd-MUexPFEyPDF:L3G+
mouse C2C12 cell	NYfI[417TnWwY4Tpc44h[XO\|YYm=			NVu4d5JvSWexbnnzeEBi[3Srdnn0fUBifCC{YYSgRXIhfHKjboPm[YN1\WRiaX6gcY92e2ViQ{LDNVIh[2WubIOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiC2cnHud4FkfGm4YYTpc44h[XO\|YYmsJGVEPTB;MD6wNlgh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG0NUc,OTdzOEGxOFE9N2F-
monkey COS7 cell	M1\HfmZ2dmO2aX;uJIF{e2G7			M{j0XWJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKG2xbnvlfUBEV1N5IHPlcIx{KGK7IIfoc4xmKGOnbHygZolv\GmwZzDhd5NigSxiS3m9NE4xODB{IN88US=>	NELBTYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0NlkyOid-MUi0OFI6OTJ:L3G+
CHO cell	M4PESmZ2dmO2aX;uJIF{e2G7			NXzjdHRvSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlibIXjbYZmemG\|ZTDhd5NigSxiRVO1NF01NjR7IN88US=>	NInWepE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwO\|I6PCd-MUizNFczQTR:L3G+
COS7 cell	MUXGeY5kfGmxbjDhd5NigQ>?			Ml\1RYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDXO\|QySyCvdYThcpQh\XiycnXzd4VlKGmwIFPPV\|ch[2WubIOgZZN{\XO\|ZXSgZZMhdHWlaX\ldoF{\SCjY4Tpeol1gSCjZoTldkAzPCCqcoOgZpkhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjBzMjFOwG0>	NGH4[289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5OFI4QSd-MkKwPVQzPzl:L3G+
COS7 cell	M1qyW2Z2dmO2aX;uJIF{e2G7			NHjSVXFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJHQ5PzeDIH31eIFvfCCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{Bie3Onc4Pl[EBieyCudXPp[oVz[XOnIHHjeIl3cXS7IHHmeIVzKDJ2IHjyd{BjgSC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR\|UxRTBwMEG1JO69VQ>?	MkP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
COS7 cell	NGraXJJHfW6ldHnvckBie3OjeR?=			NULjRXVvSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ1;TO{Bk\WyuczDhd5Nme3OnZDDhd{BtfWOrZnXyZZNmKGGldHn2bZR6KGGodHXyJFI1KGi{czDifUBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODB4MjFOwG0>	MoXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
LNCaP-hr cell	MlrHSpVv[3Srb36gZZN{[Xl?		NYLNWXF4OyCmYYnz	Mn3tRYdwdmm\|dDDhZ5Rqfmm2eTDheEBCdmS{b3flckBz\WOncITvdkBVQDd5QTDteZRidnRiaX6gbJVu[W5iTF7DZXAucHJiY3XscJMh[XO\|ZYPz[YQh[XNicILvd5RifGVic4DlZ4lncWNiYX70bYdmdiC\|ZXPy[ZRqd25ibXXhd5Vz\WRiYX\0[ZIhOyCmYYnzJIJ6KGWweont[U1qdW23bn;hd5NigSxiRVO1NF0xNjBzNTFOwG0>	NEjwVZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G5PVQ4Pyd-MkOxPVk1Pzd:L3G+
LNCaP-hr cell	MXfGeY5kfGmxbjDhd5NigQ>?		M{fXO\|Mh\GG7cx?=	M2izdWFod26rc4SgZYN1cX[rdImgZZQhf2muZDD0fZBmKEGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKEyQQ3HQMYhzKGOnbHzzJIF{e2W\|c3XkJIF{KHC{b4P0ZZRmKHOyZXPp[olkKGGwdHnn[Y4he2WlcnX0bY9vKG2nYYP1doVlKGGodHXyJFMh\GG7czDifUBmdnq7bXWtbY1ufW6xYYPzZZktKEWFNUC9NE4xODZ{IN88US=>	M4Xae\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
HEK293 cell	MVTGeY5kfGmxbjDhd5NigQ>?			MXjB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOThibl2=	M1nMUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1Olg5Lz5{NUOwOVY5QDxxYU6=
COS	M{HuU2Z2dmO2aX;uJIF{e2G7			MX;CbY5lcW6pIHHm[olvcXS7IHHnZYlve3RiQX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIFPPV{Bk\WyuczygT4khRSByLkCwNkDPxE1w	NX\aXml5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3NVU{PCd-OUi3NVU{PDxxYU6=
COS-1	Ml\LSpVv[3Srb36gZZN{[Xl?			NWX6dmFLSmmwZHnu[{Bi\m[rbnn0fUBnd3JiaIXtZY4hSW6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPPV{0yKGOnbHzzMEBMcSB;IECuNFA{KM7:TT6=	MmjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl{NUeyOUc,QTl{NUeyOVww[T5?
CV-1	MUnGeY5kfGmxbjDhd5NigQ>?			MV\B[49vcXO2IHHjeIl3cXS7IHHnZYlve3RiSIXtZY4hSW6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPWMVEh[2WubIOsJGVEPTBiPTCwMlAxPSEQvF2u	M2e3e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl7MkW3NlUoRjl7MkW3NlU9N2F-
COS	Ml;zSpVv[3Srb36gZZN{[Xl?			M2fhRWlvKH[rdILvJIJqdmSrbnegZYZncW6rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgeJJidnOoZXP0[YQhcW62bzDDU3Mh[2WubIOuMEBKSzVyIE2gNE4xODRizszNMi=>	Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB{M{C2NlgoRjFyMkOwOlI5RC:jPh?=
CV-1	MWrGeY5kfGmxbjDhd5NigQ>?			NIrCWJlKdiC4aYTyc{Bi\2:waYP0bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjD1d4lv\yClb4TyZY5{\mWldHnvckBie3OjeTDpckBEXi1zIHPlcIx{NixiRVO1NEA:KDBwMEC2JO69VS5?	M3rzZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMkOwOlI5Lz5zMEKzNFYzQDxxYU6=
CV-1	NUPEbZRiTnWwY4Tpc44h[XO\|YYm=			Mn;MRYdwdmm\|dDDhZ5Rqfmm2eTD0c{B1cGViaIXtZY4h[W6mcn;n[Y4hemWlZYD0c5IhMGiDUjmgbY4hS1ZvMTDj[YxteyxiRVO1NEA:KDBwMEC2JO69VS5?	M4DvVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlI1Lz5zMEO0NFYzPDxxYU6=
CV1	M{nSbGZ2dmO2aX;uJIF{e2G7			MVvB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHnuJGNXOSClZXzsd{Bu\WG\|dYLl[EBieyC\|dHnteYxifGmxbjDv[kBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZYN1cX[rdImgZpkh[2:2cnHud4Zm[3Srb36gZZN{[XluIFXDOVAhRSByLkCwOVEh\|ryPLh?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB\|NEGxO{c,OTdyM{SxNVc9N2F-
CV1	MV3GeY5kfGmxbjDhd5NigQ>?			MmDXRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS1ZzIHPlcIx{NCCNaTC9JFAvODByMjFOwG0v	MlzUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{NUe4N\|goRjF5MkW3PFM5RC:jPh?=
CV1	NX3EOYxYTnWwY4Tpc44h[XO\|YYm=			MWTB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMtKEWFNUCgQUAxNjByNUGg{txONg>?	M4TyXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkW3PFM5Lz5zN{K1O\|g{QDxxYU6=
MDA-MB-453	NVnQTWhkTnWwY4Tpc44h[XO\|YYm=			NETJbWVFcXOybHHj[Y1mdnRib3[gX\|NJZUSKVDDmdo9uKGi3bXHuJGFTKGW6cILld5Nm\CCrbjDNSGEuVUJvNEWzJINmdGy\|LDDLbUA:KDBwMECwN{DPxE1w	NWrnOI5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N\|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1	NUjKNJpDTnWwY4Tpc44h[XO\|YYm=			M1O5bWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w	NEDyfGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SzPVEyOid-MUe0N\|kyOTJ:L3G+
CV1	NEXNRm1HfW6ldHnvckBie3OjeR?=			NVvGSWZ{SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy\|IHL5JJRz[W6\|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIF{e2G7LDDFR\|UxKD1iMD6wNFU4KM7:TT6=	NUS4eZNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFM6OzhpPkG3O\|A{QTN6PD;hQi=>
MDA-MB-453	NFfTdHpHfW6ldHnvckBie3OjeR?=			NUj0VIE6TGm\|cHzhZ4Vu\W62IH;mJHs{UF2GSGSg[pJwdSCqdX3hckBCdmS{b3flckBz\WOncITvdkBqdiCqdX3hckBOTEFvTVKtOFU{KGOnbHzzMEBMcSB;IECuNFAxQSEQvF2u	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRyMES5PUc,OTh2MEC0PVk9N2F-
CV1	MmjBSpVv[3Srb36gZZN{[Xl?			NXO3Zo5VSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBqdiCFVkGgZ4VtdHNiYomgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZZN{[XluIFXDOVAhRSByLkCwOVch\|ryPLh?=	M3zSU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NECwOFk6Lz5zOESwNFQ6QTxxYU6=
Saos2	MUHGeY5kfGmxbjDhd5NigQ>?			NU\aPHFMSWO2aY\peJkh[XRiYX7kdo9o\W5icnXj[ZB1d3JiaX6gbJVu[W5iU3Hvd\|Ih[2WubIOgZZN{\XO\|ZXSgZZMhUUx4IILldJJme3Orb36sJGlEPTBiPTCwMlAxODB3IN88UU4>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR2MkmxNkc,OTh2NEK5NVI9N2F-
CV1	NULKVFd3TnWwY4Tpc44h[XO\|YYm=			M2jzVWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgZYZzcWOjbjDndoVmdiCvb37r[ZkhS1ZzIHPlcIx{KGK7IHPveJJidnOoZXP0bY9vKGG\|c3H5MEBGSzVyIE2gNE4xODVzIN88UU4>	NG\weFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0NlkyOid-MUi0OFI6OTJ:L3G+
MDA-kb2	MWnGeY5kfGmxbjDhd5NigQ>?			NH;RTYFC\2:waYP0JIFkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKE2GQT3rZlIh[2WubIOgZZN{\XO\|ZXSgZZMhe3SrbYXsZZRqd25ib3[gcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGVEOTVyIE2gNE4xODB3IN88UU4>	Ml;PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OUKyOFUoRjF7NUmyNlQ2RC:jPh?=
MDA-kb2	NWjpcG1jTnWwY4Tpc44h[XO\|YYm=			M3zNcGFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gUWRCNWukMjDj[YxteyCjc4Pld5Nm\CCjczDzeIlufWyjdHnvckBw\iCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVOxOVAhRSByLkCwNFUh\|ryPLh?=	NUflbJF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1PVIzPDVpPkG5OVkzOjR3PD;hQi=>
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NIH3T3	NFvBO4JHfW6ldHnvckBie3OjeR?=			NV\QOopKSWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDtc5V{\SCQSVizWFMh[2WubIOgeJJidnOrZX70cJkhfHKjboPm[YN1\WRid3n0bEBj\XSjLXfhcIFkfG:\|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bk\WyudXzhdkB1emGwc3\vdo1ifGmxbjDifUBTNVODVDDhd5NigSxiRVO1NEA:KDBwMECzPVgyKM7:TT6=	MmXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6NU[5NlEoRjF7OEW2PVIyRC:jPh?=
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Freestyle293F	Mnu1SpVv[3Srb36gZZN{[Xl?		MVuzJIhzew>?	NWXFfYVYTGm\|cHzhZ4Vu\W62IH;mJHsyPy2jbIDoZU1u\XSqeXytN2heNW2rYn;s[ZJwdmViZoLvcUBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJIRmemm4ZXSgSpJm\VO2eXzlNlk{TiClZXzsd{Bi\nSncjCzJIhzeyxiSVO1NEA:KDBwMECyNUDPxE1w	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB7NEK3PUc,OjJyOUSyO\|k9N2F-
Freestyle293F	MnjBSpVv[3Srb36gZZN{[Xl?		MX[zJIhzew>?	NHS1V5ZFcXOybHHj[Y1mdnRib3[gX\|E4NWGucHjhMY1mfGi7bD2zTH0udWmkb3zldo9v\SCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IGS4O\|dCKG23dHHueEBmgHC{ZYPz[YQhcW5iSFXLNlk{KGSncnn2[YQhTnKnZWP0fYxmOjl\|RjDj[YxteyCjZoTldkA{KGi{czygTWM2OCB;IECuNFAzPiEQvF2u	NFTNO\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5OFI4QSd-MkKwPVQzPzl:L3G+
HeLa	M1i3ZWZ2dmO2aX;uJIF{e2G7			MkfKWJJidnOjY4TpeoF1cW:wIH;mJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IITyZY5{\mWldHXkJIlvKGi3bXHuJGhmVGFiY3XscJMh[nlibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBC[3Srdnn0fUA:KDBwMEC4JO69VS5?	NIPqT4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki5O\|YyOSd-MkK4PVc3OTF:L3G+
HeLa	MUfGeY5kfGmxbjDhd5NigQ>?			MYHQZZJ1cWGuIHHnc45qe3RiYXP0bZZqfHliYYSgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhmVGFiY3XscJMh[29vZYjwdoV{e2mwZzDBVmUh[nlibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGKjc3XkJJRz[W6\|YXP0bZZifGmxbjDhd5NigSxiQXP0bZZqfHliPTCwMlAxQCEQvF2u	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3N{m0O{c,OjJ7NUe5OFc9N2F-
Freestyle293F	NGDzeJZHfW6ldHnvckBie3OjeR?=			MX\Jcohq[mm2aX;uJI9nKHerbHSgeJlx\SCDbnTyc4dmdiC{ZXPldJRweiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDGdoVme3S7bHWyPVNHKGOnbHzzMEBKSzVyIE2gNE4xODJzIN88UU4>	NXHUTXBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk1PzdpPkKzNVk6PDd5PD;hQi=>
Freestyle293F	MUjGeY5kfGmxbjDhd5NigQ>?			MnTtTY5pcWKrdHnvckBw\iCDbnTyc4dmdiC{ZXPldJRweiCWOEe3RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hTnKnZYP0fYxmOjl\|RjDj[YxteyxiSVO1NEA:KDBwMECyOkDPxE1w	M{TyWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
COS7	M3PQOmZ2dmO2aX;uJIF{e2G7		NYfXNWVDOiCqcoO=	M{CwTWRqe3CuYXPlcYVvfCCxZjDbN2heKF13YXzwbIEuTEiWIH\yc40hdW:3c3WgZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKG2xbnvlfUBEV1N5IHPlcIx{KGGodHXyJFIhcHK\|IHL5JJNkcW62aXzsZZRqd25iY3;1cpRqdmdiYX7hcJl{cXNuIFnDOVAhRSByLkCwNUDPxE1w	MlfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Mke4NVYoRjJ\|NUK3PFE3RC:jPh?=
C2C12	NUjHSpJKTnWwY4Tpc44h[XO\|YYm=		MUm1JIRigXN?	NUXsOZQ3SWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCneIDy[ZN{\WRiaX6gcY92e2ViQ{LDNVIh[2WubIOgZZN{\XO\|ZXSgZZMhd3O2ZX;icIF{fCCmaX\m[ZJmdnSrYYTpc44h[W[2ZYKgOUBl[Xm\|LDDFR\|UxKD1iMD6wNFAxPSEQvF2u	NIf4b2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFI6OCd-MkS5NFAzQTB:L3G+
C2C12	NGXHWJZHfW6ldHnvckBie3OjeR?=			MXnB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBud3W\|ZTDDNmMyOiClZXzsd{BjgSCjbnTyc4dmdi2\|cHXjbYZq[yC{ZYPwc45{\SCnbHXt[Y51NWS{aY\lckBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkCwNFE{KM7:TT6=	NFO3fGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGyNVk3PCd-MkWxNlE6PjR:L3G+
COS7	NH35UoZHfW6ldHnvckBie3OjeR?=		MkDKNlQhcHK\|	NHrtWYVC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGFTKGW6cILld5Nm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkCwN{DPxE1w	Mk\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUS4OFkoRjJ6NEW0PFQ6RC:jPh?=
Shionogi	MY\GeY5kfGmxbjDhd5NigQ>?	NHHOV4oyOCCyTR?=		NXvufHZKUW6mdXP0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZibX;1d4UhW2irb37v[4kh[2WubIOgZZQhOTBicF2=	NUjYT5dFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NVE5PTVpPkG3O\|EyQDV3PD;hQi=>
MCF7	MUjGeY5kfGmxbjDhd5NigQ>?	MoHYN\|AhfU1?	MnnSNlQhcHK\|	NGnrcJFCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFHSJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGFTKGyndnXsJIF1KDNyIIXNJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZMhemWuYYTpeoUhfG9iY3;ueJJwdA>?	NWDlUJM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVQ4PTFpPkKyNFE1PzVzPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h), and immunoblot analysis of cell lysates reveals that cyclin D1 and D2 protein expression decreased substantially with DHT treatment compared to vehicle. p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB ; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h). Immunoblot analysis of cell lysates reveals that CDK4 and CDK6 protein expression decreased and CDKN1A expression increased with DHT treatment compared to vehicle. CDK2 phosphorylation at threonine 160 (T160) decreased nearly 50% with androgen treatment at 24 and 48 hours, albeit not significantly, and total CDK2 protein expression remained unchanged. Relative to total RB expression, the levels of various phosphorylated forms of RB (S780 and S807/811) decreased over time with androgen treatment. p27 / p-p27 ; PubMed: 22139837 J Biol Chem CWR22Rv1 or CWR22R3 cells were stimulated with 10 nm DHT for 6 h, with the addition of MG132 during the last 2 h before harvesting. Proteins were then immunoblotted. AR / PP1 ; PubMed: 26636645 Oncotarget HeLa cells were transfected with Flag-PP1α and HA-AR and then incubated for overnight in androgen-depleted medium without or with androgen (10 nM of DHT) as indicated for blotting.	26372468 22139837 26636645
Immunofluorescence	FOXO1 / p27 ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with DHT (10 nm) for 4 h. The cells were immunostained for FOXO1 and p27 and examined with a confocal microscope. AKT(S473) / PKCα(S657) ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with 10 nm DHT (−/+ DHT) for 4 h. The cells were immunostained for AKT or PKCα phosphorylation and examined with a confocal microscope. Bars: 20 μm	22139837

In vivo

DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan^[2].

Protocol

Cell Research:

^[1]

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Cell lines: Bladder cancer cells
Concentrations: 1 nM
Incubation Time: 24 h
Method:
Bladder cancer cells at a density of 50-60% confluence in 24-well plates are co-transfected with 250 ng of MMTV-luc reporter plasmid DNA and 2.5 ng of PRL-TK-luc plasmid DNA. After 6 h of transfection, the medium is replaced with another medium supplemented with charcoal-stripped FBS in the presence or absence of ligands (DHT, HF, or both) for 24 h. Cells were harvested, lysed, and assayed for luciferase activity.

(Only for Reference)

Animal Research:

^[2]

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Animal Models: SOD1-G93A mutant mice with the congenic C57BL/6J background
Dosages: 5 mg
Administration: silastic implant
(Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	58 mg/mL (199.69 mM)
	Ethanol	58 mg/mL (199.69 mM)
	Water	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Dihydrotestosterone (DHT) SDF

Molecular Weight	290.44
Formula	C₁₉H₃₀O₂
CAS No.	521-18-6
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	androstanolone, stanolone, 5α-DHT
Smiles	CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

Serial Dilutions
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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04032067	Not yet recruiting	Drug: GV1001 placebo\|Drug: Proscar placebo	Benign Prostatic Hyperplasia (BPH)	GemVax & Kael	August 28 2019	Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dihydrotestosterone (DHT)