Dexmedetomidine

For research use only.

Catalog No.S3075

8 publications

Dexmedetomidine Chemical Structure

CAS No. 113775-47-6

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

Selleck's Dexmedetomidine has been cited by 8 publications

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Biological Activity

Description Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
Targets
α2 receptor [1]
1.08 nM(Ki )
In vitro

Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

Protocol

Solubility (25°C)

In vitro DMSO 40 mg/mL (199.72 mM)
Ethanol 40 mg/mL (199.72 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 200.28
Formula

C13H16N2

CAS No. 113775-47-6
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C

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Molarity Calculator

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Dilution Calculator

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04513314 Not yet recruiting Drug: Valproate|Drug: Quetiapine|Other: Standard of Care Covid19|Hyperactive Delirium|Pneumonia Viral University of Miami November 1 2021 Phase 4
NCT04730609 Not yet recruiting Drug: Dexmedetomidine Shivering|Dose Finding Study Mayo Clinic August 2021 Phase 4
NCT04973124 Not yet recruiting Drug: Dexmedetomidine|Drug: Placebo Anesthesia|Dexmedetomidine|Aging Pontificia Universidad Catolica de Chile July 15 2021 Not Applicable
NCT04798482 Recruiting Drug: Dexmedetomidine Anesthesia Boston Children''s Hospital June 1 2021 Phase 4
NCT03285087 Suspended Drug: DEX 0.2 μg/kg/h. Sedation Assiut University June 2021 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID