Dexmedetomidine

Catalog No.S3075

For research use only.

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

Dexmedetomidine Chemical Structure

CAS No. 113775-47-6

Selleck's Dexmedetomidine has been cited by 8 Publications

Purity & Quality Control

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Biological Activity

Description Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
Targets
α2 receptor [1]
1.08 nM(Ki )
In vitro

Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 40 mg/mL
(199.72 mM)
Ethanol 40 mg/mL
(199.72 mM)
Water Insoluble

Chemical Information

Molecular Weight 200.28
Formula

C13H16N2

CAS No. 113775-47-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04513314 Not yet recruiting Drug: Valproate|Drug: Quetiapine|Other: Standard of Care Covid19|Hyperactive Delirium|Pneumonia Viral University of Miami November 1 2022 Phase 4
NCT05065775 Not yet recruiting Device: Dexmedetomidine Pharmacokinetics|Arthritis Knee|Arthritis of Hip|Anesthesia Turku University Hospital November 1 2021 Phase 4
NCT05072704 Not yet recruiting Drug: Sufentanil|Drug: Dexmedetomidine Primary Total Hip Arthroplasty CMC Ambroise Paré November 1 2021 Phase 3
NCT04973124 Not yet recruiting Drug: Dexmedetomidine|Drug: Placebo Anesthesia|Dexmedetomidine|Aging Pontificia Universidad Catolica de Chile October 20 2021 Not Applicable
NCT04730609 Recruiting Drug: Dexmedetomidine Shivering|Dose Finding Study Mayo Clinic September 21 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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