For research use only.
CAS No. 113775-47-6
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
Selleck's Dexmedetomidine has been cited by 8 publications
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|Description||Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.|
Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.
|In vitro||DMSO||40 mg/mL (199.72 mM)|
|Ethanol||40 mg/mL (199.72 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04513314||Not yet recruiting||Drug: Valproate|Drug: Quetiapine|Other: Standard of Care||Covid19|Hyperactive Delirium|Pneumonia Viral||University of Miami||November 1 2021||Phase 4|
|NCT04730609||Not yet recruiting||Drug: Dexmedetomidine||Shivering|Dose Finding Study||Mayo Clinic||August 2021||Phase 4|
|NCT04973124||Not yet recruiting||Drug: Dexmedetomidine|Drug: Placebo||Anesthesia|Dexmedetomidine|Aging||Pontificia Universidad Catolica de Chile||July 15 2021||Not Applicable|
|NCT04798482||Recruiting||Drug: Dexmedetomidine||Anesthesia||Boston Children''s Hospital||June 1 2021||Phase 4|
|NCT03285087||Suspended||Drug: DEX 0.2 μg/kg/h.||Sedation||Assiut University||June 2021||Phase 2|Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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