Home Transmembrane Transporters Calcium Channel activator Chlorocresol For research use only.

Chlorocresol

Synonyms: 4-Chloro-3-methylphenol,PCMC

Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Chlorocresol Chemical Structure

Chlorocresol Chemical Structure

CAS: 59-50-7

Purity & Quality Control

Batch: S420901 DMSO] 29 mg/mL] false] Ethanol] 29 mg/mL] false] Water] Insoluble] false Purity: 99.62%
99.62

Chlorocresol Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
ryanodine receptor [1]
In vitro
In vitro

Chlorocresol (1 mM) is capable of releasing Ca2+ from a ruthenium red/caffeine-sensitive Ca2+ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca2+-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca2+ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca2+ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca2+ release channel. [1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the Kd (6.0 vs. 10 mM) and the Vmax (2.2 vs. 1.55 mmol Ca2+/min/mg protein) of caffeine-induced Ca2+ release from isolated rabbit terminal cisternae. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05255068 Completed
Alzheimer''s Disease and Related Dementias
University of Iowa
 May 16 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 142.58 Formula

C7H7ClO
CAS No. 59-50-7 SDF Download Chlorocresol SDF
Smiles CC1=C(C=CC(=C1)O)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 29 mg/mL ( (203.39 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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