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Catalog No.S4209

Chlorocresol Chemical Structure

CAS No. 59-50-7

Chlorocresol is an activator of ryanodine receptor.

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Biological Activity

Description Chlorocresol is an activator of ryanodine receptor.
ryanodine receptor [1]
In vitro

Chlorocresol (1 mM) is capable of releasing Ca2+ from a ruthenium red/caffeine-sensitive Ca2+ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca2+-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca2+ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca2+ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca2+ release channel. [1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the Kd (6.0 vs. 10 mM) and the Vmax (2.2 vs. 1.55 mmol Ca2+/min/mg protein) of caffeine-induced Ca2+ release from isolated rabbit terminal cisternae. [2]


Solubility (25°C)

In vitro DMSO 29 mg/mL (203.39 mM)
Ethanol 29 mg/mL (203.39 mM)
Water Insoluble

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Chemical Information

Molecular Weight 142.58


CAS No. 59-50-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C=CC(=C1)O)Cl

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