Cefsulodin sodium

For research use only.

Catalog No.S3670 Synonyms: Sulcephalosporin

Cefsulodin sodium Chemical Structure

CAS No. 52152-93-9

Cefsulodin (Sulcephalosporin) is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.

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Biological Activity

Description Cefsulodin (Sulcephalosporin) is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.
mPTPB [1]
16 μM
In vitro

Cefsulodin is a third generation β-lactam cephalosporin antibiotic, as a novel pTyr pharmacophore for mPTPB. Cefsulodin has also been found to exhibit inhibitory activity against SHP2 and PTP1B[1].

In vivo Cefsulodin shows maximum plasma and tissue levels 15-30 minutes after administration of a single dose of 20 mg/kg. In mice, the renal level of cefsulodin is slightly lower than the plasma level, and in rats and dogs, the renal level of cefsulodin is higher than the plasma level. The concentration of cefsulodin in the lung is relatively high in rats and dogs. On the other hand, the hepatic level is very low in all test animal species. The main route of excretion of cefsulodin is the urinary tract. About 80% of cefsulodin is excreted into the urine[3].


Animal Research:[2]
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  • Animal Models: SLC-ddY mice, JCL-Sprague Dawly rats, mongrel dogs
  • Dosages: 20 mg/kg
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (180.33 mM)
Water 100 mg/mL (180.33 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 554.53


CAS No. 52152-93-9
Storage powder
in solvent
Synonyms Sulcephalosporin
Smiles C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N.[Na+]

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID