BAY 1895344 (BAY-1895344)

For research use only.

Catalog No.S8666

1 publication

BAY 1895344 (BAY-1895344) Chemical Structure

CAS No. 1876467-74-1(freebase)

BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.

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Selleck's BAY 1895344 (BAY-1895344) has been cited by 1 publication

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Biological Activity

Description BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
ATR [1]
(Cell-free assay)
7 nM
In vitro

In vitro, BAY 1895344 is shown to be a very potent and highly selective ATR inhibitor (IC50 = 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibits hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM)[1].

In vivo BAY 1895344 reveals significantly improved aqueous solubility, bioavailability across species and no activity in the hERG patch-clamp assay. It also demonstrates very promising efficacy in monotherapy in DNA damage deficient tumor models as well as combination treatment with DNA damage inducing therapies[1]. BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models[2].


Solubility (25°C)

In vitro DMSO 82 mg/mL (199.08 mM)
Water 82 mg/mL (199.08 mM)
Ethanol 82 mg/mL (199.08 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 411.89


CAS No. 1876467-74-1(freebase)
Storage powder
in solvent
Synonyms N/A
Smiles CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04267939 Recruiting Drug: BAY1895344|Drug: Niraparib Advanced Solid Tumors (Excluding Prostate Cancer)|Ovarian Cancer Bayer February 26 2020 Phase 1
NCT04095273 Recruiting Drug: BAY1895344|Drug: Pembrolizumab Advanced Solid Tumors Bayer September 30 2019 Phase 1
NCT03188965 Recruiting Drug: BAY1895344 Neoplasms Bayer July 6 2017 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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ATM/ATR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID