Tianeptine sodium

Catalog No.S1436

For research use only.

Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used for treating major depressive episodes.

Tianeptine sodium Chemical Structure

CAS No. 30123-17-2

Selleck's Tianeptine sodium has been cited by 1 Publication

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Purity & Quality Control

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Biological Activity

Description Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used for treating major depressive episodes.
Targets
5-HT [1]
In vivo Tianeptine treatment prevents the CMS-induced increase in corticotropin-releasing factor (CRF) mRNA levels in the dBNST, and reduces corticotropin-releasing factor (CRF) mRNA levels in dBNST in non-stressed rats. Tianeptine treatment significantly decreases CRF mRNA levels in the ventral BNST and CeA of non-stressed controls as well as CMS-exposed rats. [1] Tianeptine blocks the stress-induced suppression of PB potentiation in CA1 without affecting the stress-induced enhancement of LTP in basolateral nucleus (BLA) of the amygdala in anesthetized rats. Tianeptine administered under non-stress conditions enhances PB potentiation in the hippocampus and LTP in the amygdala in anesthetized rats. [2] Tianeptine attenuates the behavioral signs of sickness behavior induced by peripheral, but not central, LPS or IL-1beta in the rats. [3] Tianeptine results in a normalized scaling of the amplitude ratio of NMDA receptor to AMPA/kainate receptor-mediated currents and prevents the stress-induced attenuation of NMDA-EPSCs deactivation in rats. [4] Tianeptine treatment significantly reduces apoptosis in the temporal cortex and dentate gyrus, both in control and stressed animals, but has no effect in the Ammons Horn. [5] Tianeptine (2.5 mg/kg, i.v.) increases the extracellular dopamine only in the nucleus accumbens. Tianeptine significantly raises the extracellular concentrations of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in both nucleus accumbens and striatum. [6]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 91 mg/mL
(198.28 mM)
Water 91 mg/mL
(198.28 mM)
Ethanol 91 mg/mL
(198.28 mM)

Chemical Information

Molecular Weight 458.93
Formula

C21H24ClN2NaO4S

CAS No. 30123-17-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)[O-].[Na+]

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

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