Molecular Weight(MW): 608.68
Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.
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(A) Changes of cAMP levels measured by the cAMP-Glo assay (Promega). Gpr52 siRNAs were tranfected for 3 days, whereas the compound treatment (forskolin: 1 μM; reserpine: 10 μM) lasts for 24 hr; statistical analyses performed by the twotailed Mann-Whitney U test. (B) Htt level measured by the 2B7/2166 HTRF upon treatment of different doses of the Gpr52 agonist reserpine for 48 hr, with transfection of Gpr52 siRNA (Gpr52_si1) vs the non-targeting control (Neg_si), n = 4.
Elife, 2015, 4:e05449.. Reserpine purchased from Selleck.
Purity & Quality Control
|Description||Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.|
Reserpine inhibits efflux pumps and reduces sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested. 
|In vivo||Reserpine (5 mg/kg s.c.) reduces extracellular DA levels to 4% of basal values in intact rats. Reserpine (5 mg/kg s.c.) diminishes L-DOPA (50 mg/kg i.p.)-induced increases in extracellular dopamine levels to 16% of those obtained in denervated animals not pretreated with reserpine in 6-hydroxydopamine-lesioned rats.  Reserpine causes a marked depletion of vasopressin/oxytocin-neu-rophysin-like immunoreactivity (LI) and CRH-L1 in the median eminence of the rat.  Reserpine significantly restores performance on the delayed response task in monkeys. Reserpine has little effect on performance of a visual discrimination task, a reference memory task which does not depend on the prefrontal cortex.  Reserpine injection (one dose of 1 mg/kg s.c.) every other day for 3 days causes a significant increase in vacuous chewing, tongue protrusion and duration of facial twitching in rats, compared to the control. Reserpine results in a decreased glutamate uptake in the subcortical parts of rats.  Reserpine (5 mg/kg) significantly increases vacuous jaw movements, and also reduces rearing behavior in all age groups of rats. |
-  Schmitz FJ, et al. J Antimicrob Chemother, 1998, 42(6), 807-810.
-  Kannari K, et al. J Neurochem, 2000, 74(1), 263-269.
-  Ceccatelli S, et al. Brain Res Mol Brain Res, 1991, 9(1-2), 57-69.
|In vitro||DMSO||13 mg/mL (21.35 mM)|
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