(-)-Parthenolide

For research use only.

Catalog No.S2341

19 publications

(-)-Parthenolide Chemical Structure

CAS No. 20554-84-1

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

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Selleck's (-)-Parthenolide has been cited by 19 publications

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Biological Activity

Description (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Targets
HDAC1 [1] NF-κB [2] MDM2 ubiquitination [3] p53 [3]
()
Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bak / Bax ; 

PubMed: 23039130     


Analysis showed that parthenolide decreased the protein expression of Bcl-2 and increased the protein expression of Bak and Bax in a dose-dependent fashion. 

STAT3 / p-STAT3 / GSK3α/β / AKT / p-AKT ; 

PubMed: 28423582     


Total and phosphorylated levels of STAT3, GSK3α/β and Akt after treatment with 0, 2.5, 5.0, 10.0, 20.0 μM parthenolide for 6 h.

MEK / p-MEK / ERK / p-ERK ; 

PubMed: 28423582     


Level of MEK, p-MEK, Erk, p-Erk detected after treatment with 0, 2.5, 5.0, 10.0, 20.0 μM parthenolide for 6 h.

B-Raf / c-Myc ; 

PubMed: 28423582     


(A, B) Protein expression of B-Raf and c-Myc after treatment with 20.0 μM parthenolide for 0, 6, 12, 24, 36 and 48 h.

23039130 28423582
Growth inhibition assay
Cell viability ; 

PubMed: 28423582     


(A) Chemical structure of parthenolide (molecular weight: 248.32 g/mol); (B–F) Parthenolide inhibited GLC-82, A549, PC-9, H1650 and H1299 cells survival. Survival (%) = (mean experimental absorbance/mean control absorbance) × 100%; 

28423582

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (197.32 mM)
Ethanol 49 mg/mL warmed (197.32 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 248.32
Formula

C15H20O3

CAS No. 20554-84-1
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID