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Catalog No.S2341

18 publications

(-)-Parthenolide Chemical Structure

CAS No. 20554-84-1

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

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Selleck's (-)-Parthenolide has been cited by 18 publications

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  •  G. To evaluate effects of IKBKE/TBK1 inhibition on NF-κB signaling in Ewing, TC32 cells were incubated with CYT387 for six hours prior to stimulation with TNF-α (30 ng/mL). IκBα degradation was measured by harvesting TC32 cells thirty minutes after stimulation with TNF-α. TNF-α stimulation resulted in degradation of IκBα, and this effect was attenuated with CYT387 treatment. Parthenolide, an inhibitor of IκBα phosphorylation was used as a positive control. Similar effects of CYT387 activity were seen in HEK-293T cells which also express IKBKΕ. Nuclear extracts were prepared from TC32 cells harvested following forty-five minutes of TNF-α stimulation. Treatment with CYT387 resulted in decreased nuclear localization of NF-κB family proteins RelA/p65 and c-Rel. There was a modest impairment of p50 nuclear localization as compared to parthenolide and DMSO controls and no change in p52 nuclear localization. RelB (not shown) is not expressed in TC32 cells

    Harvard University, 2014.. (-)-Parthenolide purchased from Selleck.

  • Induction of apoptosis by HDAC and DNMT1 inhibitors. a-c/ Membrane permeability apoptosis and necrosis assays were performed in which apoptotic cells positively stain for YO-PRO1 and necrotic cells positively stain for PI. Cells undergoing late apoptosis positively stain for both YO-PRO1 and PI. Nuclei were counterstained with Hoechst 33342. Apoptosis assay results are shown for Daoy cells that were exposed to: a/DMSO, b/2 μMparthenolide and c/2 μMparthenolide plus 33 nM 5-azadC, each for 24 h and 48 h, as indicated. d–f Annexin Vapoptosis assays of Daoy cells exposed to (d) DMSO, (e) 2 μMparthenolide and (f) 2 μM parthenolide plus 33 nM 5-aza-dC for 24 h. Nuclei were counterstained with DAPI.

    Cell Oncol (Dordr), 2017, 40(3):263-279. (-)-Parthenolide purchased from Selleck.

  • PAR inhibited the production of TNF-α and IL-17 in vitro in a dose dependent manner. Lymph node MNCs harvested from EAN rats on day 8 p.i. were cultured in the presence of BPM and a series of concentrations of PAR. 72 h later, culture supernatants were collected and the levels of TNF-α and IL-17 were detected by ELISA. The results are expressed as mean ± SD (*p < 0.05, **p < 0.01). Data represented three experiments.

    J Neuroimmunol, 2017, 305:154-161. (-)-Parthenolide purchased from Selleck.

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Description (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
HDAC1 [1] NF-κB [2] MDM2 ubiquitination [3] p53 [3]
Methods Test Index PMID
Growth inhibition assay
Cell viability ; 

PubMed: 28423582     

(A) Chemical structure of parthenolide (molecular weight: 248.32 g/mol); (B–F) Parthenolide inhibited GLC-82, A549, PC-9, H1650 and H1299 cells survival. Survival (%) = (mean experimental absorbance/mean control absorbance) × 100%; 

Western blot
B-Raf / c-Myc ; 

PubMed: 28423582     

(A, B) Protein expression of B-Raf and c-Myc after treatment with 20.0 μM parthenolide for 0, 6, 12, 24, 36 and 48 h.

MEK / p-MEK / ERK / p-ERK ; 

PubMed: 28423582     

Level of MEK, p-MEK, Erk, p-Erk detected after treatment with 0, 2.5, 5.0, 10.0, 20.0 μM parthenolide for 6 h.

STAT3 / p-STAT3 / GSK3α/β / AKT / p-AKT ; 

PubMed: 28423582     

Total and phosphorylated levels of STAT3, GSK3α/β and Akt after treatment with 0, 2.5, 5.0, 10.0, 20.0 μM parthenolide for 6 h.

Bcl-2 / Bak / Bax ; 

PubMed: 23039130     

Analysis showed that parthenolide decreased the protein expression of Bcl-2 and increased the protein expression of Bak and Bax in a dose-dependent fashion. 

28423582 23039130


Solubility (25°C)

In vitro DMSO 49 mg/mL (197.32 mM)
Ethanol 49 mg/mL warmed (197.32 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
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* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 248.32


CAS No. 20554-84-1
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID