Luteolin

Catalog No.S2320

Luteolin Chemical Structure

Molecular Weight(MW): 286.24

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 170 In stock
USD 570 In stock
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Cited by 2 Publications

1 Customer Review

  • Bioactive compounds inhibit recombinant HDAC activity. Recombinant HDACs were incubated with flavonoid Luteolin (C) for 2 h prior to the addition of cell permeable HDAC substrates. Luteolin inhibited activity of most classes I, IIa, and IIb HDAC isoforms.

    Mol Nutr Food Res, 2017, doi: 10.1002/mnfr.201600744. Luteolin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells MnLSSpVv[3Srb36gZZN{[Xl? NFTGTpQzKGh? MXXJcohq[mm2aX;uJI9nKE6RIIDyc4R2[3Srb36gbY4hVFCVLYP0bY12dGG2ZXSgcY92e2ViUlHXNlY1NjdiY3XscJMheHKnLXnuZ5Vj[XSnZDDmc5IhOiCqcoOgZoVnd3KnIFzQV{B{fGmvdXzheIlwdiCob4KgNlQhcHK|IHL5JGdzcWW|czDhd5NigSCvZYToc4QtKEmFNUC9NE4zOSEQvF2= MUOyOVE4PjF6Nx?=
HEK293 FS cells MYPGeY5kfGmxbjDhd5NigQ>? M3PCcWlvcGmkaYTpc44hd2ZiTl;YOEBmgHC{ZYPz[YQhcW5iSFXLNlk{KE[VIHPlcIx{KGG|c3Xzd4VlKGG|IFiyU|IheHKxZIXjeIlwdiCkeTDINm8zN1S7cj;MVG8h[XO|YYmsJGlEPTB;MD64OUDPxE1? MmPsNlA4OzF|NUe=
CHO cells NU\2S|VSTnWwY4Tpc44h[XO|YYm= Mny4RYdwdmm|dDDhZ5Rqfmm2eTDheEBz[XRiRFHUJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNuIFXDOVA:OS52NTFOwG0> MkHwNlA6PzF4NUC=
human MV4-11 cells NYTWOJVvS3m2b4TvfIlkcXS7IHHzd4F6 NYGxd2JUPzJiaB?= M1:1TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9NU44PiEQvF2= Ml\1NlM1OTFyN{O=
HEK293 cells MmPrSpVv[3Srb36gZZN{[Xl? MYGyOEBp NHrYZZFC\2:waYP0JIFkfGm4aYT5JIF1KG2xdYPlJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJINwNWW6cILld5Nqdmdid3n0bEBI[Wx2IILldI9zfGW{II\lZ5RweiCjZoTldkAzPCCqcoOgZpkh\HWjbD3seYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7LDDFR|UxRTJwMzFOwG0> NInwPW4zPDl3NUi4PS=>
human U2OS cells MXLGeY5kfGmxbjDhd5NigQ>? MXS1JIg> M3;0XGFod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gWVJQWyClZXzsd{Bkd2W6cILld5NqdmdiR3HsOE1XWDF4LWTFWkBie3Onc4Pl[EBieyCkZYThJIFzemW|dHnuJJRz[W6|bH;jZZRqd25iYX\0[ZIhPSCqcoOgZpkh[mW2YTDsZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zMlIh|ryP NGPXUmQzPDlyMES0Oy=>
RBL-2H3 cells NFX1fY5HfW6ldHnvckBie3OjeR?= MmjwTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGlNNTRicILv[JVkfGmxbjDpckBTSkxvMlizJINmdGy|IIfhd{Bl\XSncn3pcoVlNCCLQ{WwQVMvPyEQvF2= M13BclEzQTVzMEmy
human mast cells NYTsW4x7TnWwY4Tpc44h[XO|YYm= M3zwVmlvcGmkaYTpc44hd2ZiU2nLJIlvKGi3bXHuJI1ie3RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJI1ie3RiY3XscEBl\We{YX71cIF1cW:wLDDFR|UxRTRwNTFOwG0> NIjDfZEzOjJ3N{KxNy=>
human LNCAP cells MWrGeY5kfGmxbjDhd5NigQ>? M2myZ2Rwf26{ZXf1cIF1cW:wIH;mJJBzd3O2YYTlJJNx\WOrZnnjJIFvfGmpZX6gd4VkemW2aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{NCCLQ{WwQVUh|ryP NH\HdXEzPTBzOUS3PC=>
rat H9c2 cells MnzXSpVv[3Srb36gZZN{[Xl? NUHDblFxOjRiaB?= MnXNR5l1d3C{b4TlZ5RqfmViYXP0bZZqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3pcoR2[2WmIHP5eI91d3irY3n0fUBqdiC{YYSgTFlkOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUWuOVMh|ryP Mn;3NlA6OzJ5NkK=
human HT-29 cells M4[w[WZ2dmO2aX;uJIF{e2G7 M2\uOFExKG2rboO= NYTVPHEzSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBJXC1{OTDj[YxteyCjZoTldkAyOCCvaX7zJIJ6KGS7bnHtbYMhdWG|czDy[YRqe3S{aXL1eIlwdiCjc4PhfUwhTUN3ME23MlI1KM7:TR?= M4DvV|I1QTByNES3
human RS4:11 cells MnHQR5l1d3SxeHnjbZR6KGG|c3H5 MkPYO|IhcA>? M{CxbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJUPDpzMTDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIF\MWFMh[W[2ZYKgO|IhcHK|IHL5JJRmfHKjen;sbZVuKGKjc3XkJGV7KEO7VH;4JINmdGxidnnhZoltcXS7IHHzd4F6NCCJSUWwQVcvOjVizszN M3izWFI{PDFzMEez
NCI-H460 cells MmfzSpVv[3Srb36gZZN{[Xl? M2D1d|IuOjBiaB?= MXTJcohq[mm2aX;uJI9nKEGEQ1eyJIV5eHKnc4Pl[EBqdiCqdX3hckBPS0lvSES2NEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGDoRUBi[2O3bYXsZZRqd25iYX\0[ZIhOiC2bzCyNEBpenNicnXsZZRqfmVidH:g[pVucXS{ZX3vdodqdiCFLDDJR|UxRThwOTFOwG0> MViyNVI4PTN6Nh?=
human H9 cells M3\FeGZ2dmO2aX;uJIF{e2G7 M2fFV|Mh\GG7cx?= MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KHB{NDDhcpRq\2WwIHPhdJR2emViYYPzZZktKEWFNUC9NVAh|ryP MXq4NVU5OTZ2
MDCK cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= NGDBdG1EgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|IHL5JG1VXCCjc4PhfUwhS0N3ME2xNk41PCEQvF2= M3nwclE5PjRyMESy
mouse B16-4A5 cells NUjlTpRbTnWwY4Tpc44h[XO|YYm= NXHLS3J4PzJiaB?= NIHlfHlKdmirYnn0bY9vKG:oIITo[Y9xcHmubHnu[U1{fGmvdXzheIVlKG2nbHHuc4dmdmW|aYOgbY4hdW:3c3WgRlE3NTSDNTDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MUSg{txO NEnFZlkzODF6OUO5PS=>
K562 cells NFvmVJRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVLySmFkPSCmYYnz NIOxTmFIem:5dHigbY5pcWKrdHnvckBw\iCNNU[yJINmdGy|IHL5JHhVXCCjc4PhfUBi\nSncjC1JIRigXNuIFnDOVA:OTRwNkWg{txO M4PVeVE4PDFzMEmy
human H9 cells NWDtSYc6S3m2b4TvfIlkcXS7IHHzd4F6 NXLQUWNPOyCmYYnz M1P5dWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg6KGOnbHzzJIFnfGW{IEOg[IF6eyxiSVO1NF0yPiEQvF2= NGnL[|Q5OTV6MU[0
human HT-29 cells NETxblBHfW6ldHnvckBie3OjeR?= M3\TPFExKG2rboO= MXzE[ZNmdnOrdHn6ZZRqd25ib3[gS3BTOzVicnXj[ZB1d3JiaX6gbJVu[W5iSGStNlkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD6ZZBzcW6jc4StbY5lfWOnZDDkfY5idWmlIH3hd5MhemWmaYP0doljfXSrb36gZYZ1\XJiMUCgcYlveyxiSVO1NF0yQC54IN88US=> NHHRPHkzPDlyMES0Oy=>
human U937 cells NIjkSnhRem:uaX\ldoF1cW:wIHHzd4F6 MnzPO|IhcA>? MoHxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2StPEBie3OjeTygTWM2OD1{MDFOwG0> NWe2XJB{OTdzNUiwOVQ>
mouse HT22 cells NYCz[XIzTnWwY4Tpc44h[XO|YYm= NWP6[mhpOyCq NF:2SJFP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyC2LVLPU2gucW6mdXPl[EB1d3irY3n0fUBifCB2MDD1UUBxemWrbnP1ZoF1\WRiZn;yJFMhcHK|IH\vcIxwf2WmIHL5JJQuSk:RSDDpcoR2[3Srb36gcYVie3W{ZXSgZYZ1\XJiOTDodpMh[nliTWTUJIF{e2G7 MX6yOFI1PTl|OR?=
human THP1 cells MlnCSpVv[3Srb36gZZN{[Xl? NIXndpQzOCEQvF2= NEH0OJMyKGh? NXS3S3JsTG:5boLl[5Vt[XSrb36gc4YhXFCDLXnu[JVk\WRiTl;YNkBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gWGhROSClZXzsd{BifCB{MDD1UUBqdmO3YnH0[YQh\m:{IEGgbJIheHKrb4KgeI8hXFCDIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliUmStVGNTKGGwYXz5d4l{ M3rQT|I{Pzh4NUKw
MDA-MB-231 cells NF3qWm9HfW6ldHnvckBie3OjeR?= MUS1JO69VQ>? MXmxOkBp MUnJcohq[mm2aX;uJI9nKFCPQT3zeIlufWyjdHXkJG5HNWujcIDhRkB{cWewYXzpcochMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iTVTBMW1DNTJ|MTDj[YxteyCjdDC1JJVOKGmwY4XiZZRm\CCob4KgNVYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NInSPFAzPTF7MES2Oi=>
HL60 cells MV7Qdo9tcW[ncnH0bY9vKGG|c3H5 NHH3OJQ{OCEQvF2= MmnpOFghcA>? NH3xeIRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZQhOzBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeR?= MmHxNVgzPTh2NEC=

... Click to View More Cell Line Experimental Data

In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.13 mM)
Ethanol 3 mg/mL warmed (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Would you please suggest a suitable vehicle to dissolve Luteolin for in vivo i.p. use?

  • Answer:

    Formula: 5% DMSO+40% PEG 300+5% Tween80+ddH2O, working Solution concentration: up to 7.5mg/ml, stable for 30min.

PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID