Luteolin

Catalog No.S2320 Synonyms: Luteoline, Luteolol, Digitoflavone

For research use only.

Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Luteolin Chemical Structure

CAS No. 491-70-3

Selleck's Luteolin has been cited by 17 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells NHnBN5pHfW6ldHnvckBie3OjeR?= M2HKRlIhcA>? Mm\UTY5pcWKrdHnvckBw\iCQTzDwdo9lfWO2aX;uJIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIGLBW|I3PC55IHPlcIx{KHC{ZT3pcoN2[mG2ZXSg[o9zKDJiaILzJIJm\m:{ZTDMVHMhe3SrbYXsZZRqd25iZn;yJFI1KGi{czDifUBIemmnc4OgZZN{[XlibXX0bI9lNCCLQ{WwQVAvOjFizszN MmC0NlUyPzZzOEe=
HEK293 FS cells NE\0ZW5HfW6ldHnvckBie3OjeR?= MljMTY5pcWKrdHnvckBw\iCQT2i0JIV5eHKnc4Pl[EBqdiCKRVuyPVMhTlNiY3XscJMh[XO|ZYPz[YQh[XNiSELPNkBxem:mdXP0bY9vKGK7IFiyU|IwXHm{L1zQU{Bie3OjeTygTWM2OD1yLki1JO69VQ>? NWjLT5lrOjB5M{GzOVc>
CHO cells NGrXNnVHfW6ldHnvckBie3OjeR?= NYjmUYxISWexbnnzeEBi[3Srdnn0fUBifCC{YYSgSGFVKGW6cILld5Nm\CCrbjDDTG8h[2WubIOsJGVEPTB;MT60OUDPxE1? MVGyNFk4OTZ3MB?=
human MV4-11 cells MV3DfZRwfG:6aXPpeJkh[XO|YYm= NWnHfmNEPzJiaB?= M37TO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9NU44PiEQvF2= M1m1WlI{PDFzMEez
HEK293 cells NUfqVXhpTnWwY4Tpc44h[XO|YYm= NX3sXnkyOjRiaB?= NF7NOFhC\2:waYP0JIFkfGm4aYT5JIF1KG2xdYPlJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJINwNWW6cILld5Nqdmdid3n0bEBI[Wx2IILldI9zfGW{II\lZ5RweiCjZoTldkAzPCCqcoOgZpkh\HWjbD3seYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7LDDFR|UxRTJwMzFOwG0> NVqzeFhQOjR7NUW4PFk>
human U2OS cells NH3K[|lHfW6ldHnvckBie3OjeR?= MXu1JIg> M1\EO2Fod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gWVJQWyClZXzsd{Bkd2W6cILld5NqdmdiR3HsOE1XWDF4LWTFWkBie3Onc4Pl[EBieyCkZYThJIFzemW|dHnuJJRz[W6|bH;jZZRqd25iYX\0[ZIhPSCqcoOgZpkh[mW2YTDsZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2zMlIh|ryP M371N|I1QTByNES3
RBL-2H3 cells NUDvd4NbTnWwY4Tpc44h[XO|YYm= NY\5OJJLUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEmOLUSgdJJw\HWldHnvckBqdiCUQlytNmg{KGOnbHzzJJdieyCmZYTldo1qdmWmLDDJR|UxRTNwNzFOwG0> NGO0VpAyOjl3MUC5Ni=>
human mast cells MknkSpVv[3Srb36gZZN{[Xl? M2HWT2lvcGmkaYTpc44hd2ZiU2nLJIlvKGi3bXHuJI1ie3RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJI1ie3RiY3XscEBl\We{YX71cIF1cW:wLDDFR|UxRTRwNTFOwG0> MmPzNlIzPTd{MUO=
human LNCAP cells NHXzU4FHfW6ldHnvckBie3OjeR?= M4LG[WRwf26{ZXf1cIF1cW:wIH;mJJBzd3O2YYTlJJNx\WOrZnnjJIFvfGmpZX6gd4VkemW2aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{NCCLQ{WwQVUh|ryP M{DlclI2ODF7NEe4
rat H9c2 cells MnrrSpVv[3Srb36gZZN{[Xl? MUmyOEBp M2fmZWN6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkhcW5icnH0JGg6[zJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhTUN3ME21MlU{KM7:TR?= NH3DXFYzODl|Mke2Ni=>
human HT-29 cells NIn5V3JHfW6ldHnvckBie3OjeR?= M2m3Z|ExKG2rboO= M1vT[2Fod26rc4SgZYN1cX[rdImgZZQhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgNVAhdWmwczDifUBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[XO|YYmsJGVEPTB;Nz6yOEDPxE1? MVuyOFkxODR2Nx?=
human RS4:11 cells M1HPb2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXy3NkBp NUPxN4NPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWlN2OkGxJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSmxVOyCjZoTldkA4OiCqcoOgZpkhfGW2cnH6c4xqfW1iYnHz[YQhTXpiQ4nUc5gh[2WubDD2bYFjcWyrdImgZZN{[XluIFfJOVA:Py5{NTFOwG0> MXOyN|QyOTB5Mx?=
NCI-H460 cells MV7GeY5kfGmxbjDhd5NigQ>? NUHrNnVWOi1{MDDo NILTSphKdmirYnn0bY9vKG:oIFHCR2czKGW6cILld5Nm\CCrbjDoeY1idiCQQ1mtTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHBpSSCjY3P1cZVt[XSrb36gZYZ1\XJiMjD0c{AzOCCqcoOgdoVt[XSrdnWgeI8h\nWvaYTy[Y1wemerbjDDMEBKSzVyPUiuPUDPxE1? MoDINlEzPzV|OE[=
human H9 cells NXLIVWxmTnWwY4Tpc44h[XO|YYm= NHjKZm4{KGSjeYO= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKDOEIHnu[oVkfGWmIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KHB{NDDhcpRq\2WwIHPhdJR2emViYYPzZZktKEWFNUC9NVAh|ryP MoKyPFE2QDF4NB?=
MDCK cells MlO1R5l1d3SxeHnjbZR6KGG|c3H5 M1q1R2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQ1ugZ4VtdHNiYomgUXRVKGG|c3H5MEBESzVyPUGyMlQ1KM7:TR?= Mn7yNVg3PDByNEK=
mouse B16-4A5 cells MWrGeY5kfGmxbjDhd5NigQ>? MlPYO|IhcA>? NFrxdmZKdmirYnn0bY9vKG:oIITo[Y9xcHmubHnu[U1{fGmvdXzheIVlKG2nbHHuc4dmdmW|aYOgbY4hdW:3c3WgRlE3NTSDNTDj[YxteyCjZoTldkA4OiCqcoOsJGlEPTB;MUSg{txO MYeyNFE5QTN7OR?=
K562 cells MmPMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7sUXM2KGSjeYO= MYrHdo94fGhiaX7obYJqfGmxbjDv[kBMPTZ{IHPlcIx{KGK7IGjUWEBie3OjeTDh[pRmeiB3IHThfZMtKEmFNUC9NVQvPjVizszN MluyNVc1OTFyOUK=
human H9 cells NY\KVHFMS3m2b4TvfIlkcXS7IHHzd4F6 M4rTZlMh\GG7cx?= NIrJN3NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJQSClZXzsd{Bi\nSncjCzJIRigXNuIFnDOVA:OTZizszN NIPWNVQ5OTV6MU[0
human HT-29 cells NHPvcpJHfW6ldHnvckBie3OjeR?= MXixNEBucW6| NGfXVIdF\XOnboPpeIl7[XSrb36gc4YhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB7[XC{aX7hd5QucW6mdXPl[EBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[W[2ZYKgNVAhdWmwczygTWM2OD1zOD62JO69VQ>? NUTVbJhwOjR7MEC0OFc>
human U937 cells M4\VXXBzd2yrZnXyZZRqd25iYYPzZZk> NIXHO3o4OiCq NEHudWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUKwJO69VQ>? M1TpXFE4OTV6MEW0
mouse HT22 cells MXXGeY5kfGmxbjDhd5NigQ>? MYSzJIg> NXHHXnEzVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNidD3CU29JNWmwZIXj[YQhfG:6aXPpeJkh[XRiNECgeW0heHKnaX7jeYJifGWmIH\vdkA{KGi{czDmc4xtd3enZDDifUB1NUKRT1igbY5lfWO2aX;uJI1m[XO3cnXkJIFnfGW{IEmgbJJ{KGK7IF3UWEBie3OjeR?= NVOzO2JGOjR{NEW5N|k>
human THP1 cells MVzGeY5kfGmxbjDhd5NigQ>? NUjuRm94OjBizszN MYKxJIg> MYnEc5dvemWpdXzheIlwdiCxZjDUVGEucW6mdXPl[EBPV1h{IH3SUmEh\XiycnXzd4lwdiCrbjDoeY1idiCWSGCxJINmdGy|IHH0JFIxKHWPIHnuZ5Vj[XSnZDDmc5IhOSCqcjDwdolweiC2bzDUVGEh[2ijbHzlcodmKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBTXC2SQ2KgZY5idHm|aYO= NFzjPIEzOzd6NkWyNC=>
MDA-MB-231 cells MYrGeY5kfGmxbjDhd5NigQ>? NVXaS2dJPSEQvF2= NXvNSJhDOTZiaB?= MXXJcohq[mm2aX;uJI9nKFCPQT3zeIlufWyjdHXkJG5HNWujcIDhRkB{cWewYXzpcochMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iTVTBMW1DNTJ|MTDj[YxteyCjdDC1JJVOKGmwY4XiZZRm\CCob4KgNVYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? M1;SPVI2OTlyNE[2
HL60 cells MoT3VJJwdGmoZYLheIlwdiCjc4PhfS=> MnvXN|Ah|ryP MV[0PEBp NXjue4FTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF1KDNyIIXNJIFnfGW{IES4JIhzeyCkeTDNWHMh[XO|YYm= MmHGNVgzPTh2NEC=
Assay
Methods Test Index PMID
Western blot TET1 / TET2 / TET3 ; DNMT1 / DMNT3A / DNMT3B ; p21 / Survivin / Cyclin D1 ; p-VEGFR2 / p-mTOR / pS6K1 / p70S6K1 / pAKT / AKT / MMP-2 / MMP-9 ; ERK / p-ERK / JNK / p-JNK / p38 / p-p38 / Bax / Bcl-2 ; Caspase-3 / Cleaved Caspase-3 / Caspase-8 / Cleaved Caspase-8 ; FADD / PARP / Cleaved PARP 30988303 30930986 23300633 30992674
Immunofluorescence 5-hmC 30988303
Growth inhibition assay Cell viability 30992674
In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Would you please suggest a suitable vehicle to dissolve Luteolin for in vivo i.p. use?

Answer:
Formula: 5% DMSO+40% PEG 300+5% Tween80+ddH2O, working Solution concentration: up to 7.5mg/ml, stable for 30min.

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