Luteolin

Catalog No.S2320 Synonyms: Luteoline, Luteolol, Digitoflavone

For research use only.

Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Luteolin Chemical Structure

CAS No. 491-70-3

Selleck's Luteolin has been cited by 14 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells MnzFSpVv[3Srb36gZZN{[Xl? NYnhdY9WOiCq NUnZdZN5UW6qaXLpeIlwdiCxZjDOU{Bxem:mdXP0bY9vKGmwIFzQV{1{fGmvdXzheIVlKG2xdYPlJHJCXzJ4ND63JINmdGy|IIDy[U1qdmO3YnH0[YQh\m:{IEKgbJJ{KGKnZn;y[UBNWFNic4TpcZVt[XSrb36g[o9zKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmgcYV1cG:mLDDJR|UxRTBwMkGg{txO NX3vfnVYOjVzN{[xPFc>
HEK293 FS cells MVLGeY5kfGmxbjDhd5NigQ>? NI\helVKdmirYnn0bY9vKG:oIF7PXFQh\XiycnXzd4VlKGmwIFjFT|I6OyCIUzDj[YxteyCjc4Pld5Nm\CCjczDINm8zKHC{b3T1Z5Rqd25iYomgTFJQOi:WeYKvUHBQKGG|c3H5MEBKSzVyPUCuPFUh|ryP M4X2b|IxPzNzM{W3
CHO cells MUfGeY5kfGmxbjDhd5NigQ>? Mm\TRYdwdmm|dDDhZ5Rqfmm2eTDheEBz[XRiRFHUJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNuIFXDOVA:OS52NTFOwG0> Ml\zNlA6PzF4NUC=
human MV4-11 cells MWXDfZRwfG:6aXPpeJkh[XO|YYm= Mki1O|IhcA>? NEnOcWVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXjRvMUGgZ4VtdHNiaHHyZo9zcW6pIF\MWFMhdXW2YYTpc44h[W[2ZYKgO|IhcHK|IHL5JJRmfHKjen;sbZVuKGKjc3XkJGV7KEO7VH;4JINmdGxidnnhZoltcXS7IHHzd4F6NCCJSUWwQVEvPzZizszN M2HrO|I{PDFzMEez
HEK293 cells NXzFW2lsTnWwY4Tpc44h[XO|YYm= MlSyNlQhcA>? MUHB[49vcXO2IHHjeIl3cXS7IHH0JI1wfXOnIGDQRXJo[W2vYTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHPvMYV5eHKnc4Ppcochf2m2aDDHZYw1KHKncH;yeIVzKH[nY4TvdkBi\nSncjCyOEBpenNiYomg[JVidC2udXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVIvOyEQvF2= NXrve5pVOjR7NUW4PFk>
human U2OS cells MWTGeY5kfGmxbjDhd5NigQ>? MnjLOUBp Mk\vRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWFJ|NTDy[YNmeHSxcjDpckBpfW2jbjDVNm9UKGOnbHzzJINw\XiycnXzd4lv\yCJYXy0MXZROTZvVFXWJIF{e2W|c3XkJIF{KGKndHGgZZJz\XO2aX6geJJidnOub3PheIlwdiCjZoTldkA2KGi{czDifUBj\XSjIHzhZ5RidWG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUOuNkDPxE1? MUOyOFkxODR2Nx?=
RBL-2H3 cells MnP6SpVv[3Srb36gZZN{[Xl? NFOze5hKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUUxvNDDwdo9lfWO2aX;uJIlvKFKETD2yTFMh[2WubIOge4F{KGSndHXycYlv\WRuIFnDOVA:Oy55IN88US=> NVfPfZhYOTJ7NUGwPVI>
human mast cells MWXGeY5kfGmxbjDhd5NigQ>? MnH1TY5pcWKrdHnvckBw\iCVWVugbY4hcHWvYX6gcYF{fCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gcYF{fCClZXzsJIRm\3KjboXsZZRqd25uIFXDOVA:PC53IN88US=> MkT2NlIzPTd{MUO=
human LNCAP cells NVLkRld6TnWwY4Tpc44h[XO|YYm= M{nnTWRwf26{ZXf1cIF1cW:wIH;mJJBzd3O2YYTlJJNx\WOrZnnjJIFvfGmpZX6gd4VkemW2aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{NCCLQ{WwQVUh|ryP NYThZ2lFOjVyMUm0O|g>
rat H9c2 cells MV7GeY5kfGmxbjDhd5NigQ>? NID1RY0zPCCq MUDDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDIPYMzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61N{DPxE1? MWeyNFk{Ojd4Mh?=
human HT-29 cells MkewSpVv[3Srb36gZZN{[Xl? MkPrNVAhdWmwcx?= MU\B[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEGwJI1qdnNiYomg[Jlv[W2rYzDtZZN{KHKnZHnzeJJq[nW2aX;uJIF{e2G7LDDFR|UxRTdwMkSg{txO NInNV2YzPDlyMES0Oy=>
human RS4:11 cells MUDDfZRwfG:6aXPpeJkh[XO|YYm= MlTmO|IhcA>? NV;EdnBmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWlN2OkGxJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSmxVOyCjZoTldkA4OiCqcoOgZpkhfGW2cnH6c4xqfW1iYnHz[YQhTXpiQ4nUc5gh[2WubDD2bYFjcWyrdImgZZN{[XluIFfJOVA:Py5{NTFOwG0> NVr2XmNvOjN2MUGwO|M>
NCI-H460 cells NH7nUIFHfW6ldHnvckBie3OjeR?= M1rSN|IuOjBiaB?= M1;KZmlvcGmkaYTpc44hd2ZiQVLDS|Ih\XiycnXzd4VlKGmwIHj1cYFvKE6FST3IOFYxKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVIhCKGGlY4XteYxifGmxbjDh[pRmeiB{IITvJFIxKGi{czDy[YxifGm4ZTD0c{BnfW2rdILlcY9z\2mwIFOsJGlEPTB;OD65JO69VQ>? NELZSWEzOTJ5NUO4Oi=>
human H9 cells MWjGeY5kfGmxbjDhd5NigQ>? MnviN{Bl[Xm| NVvVT41kSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDwNlQh[W62aXflckBk[XC2dYLlJIF{e2G7LDDFR|UxRTFyIN88US=> MlnUPFE2QDF4NB?=
MDCK cells M3vwRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFy5XYxEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|IHL5JG1VXCCjc4PhfUwhS0N3ME2xNk41PCEQvF2= MUSxPFY1ODB2Mh?=
mouse B16-4A5 cells M3PjVGZ2dmO2aX;uJIF{e2G7 MUG3NkBp MWXJcohq[mm2aX;uJI9nKHSqZX;wbJltdGmwZT3zeIlufWyjdHXkJI1mdGGwb3flcoV{cXNiaX6gcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OTRizszN MknHNlAyQDl|OUm=
K562 cells NEPlTGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVm1JIRigXN? Mom0S5Jwf3SqIHnubIljcXSrb36gc4YhUzV4MjDj[YxteyCkeTDYWHQh[XO|YYmgZYZ1\XJiNTDkZZl{NCCLQ{WwQVE1NjZ3IN88US=> NXvTO5hoOTd2MUGwPVI>
human H9 cells MV;DfZRwfG:6aXPpeJkh[XO|YYm= MUCzJIRigXN? NUjwWo9xS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDliY3XscJMh[W[2ZYKgN{Bl[Xm|LDDJR|UxRTF4IN88US=> NXPJbINQQDF3OEG2OC=>
human HT-29 cells MUPGeY5kfGmxbjDhd5NigQ>? MUOxNEBucW6| NH;GWmFF\XOnboPpeIl7[XSrb36gc4YhT1CUM{WgdoVk\XC2b4KgbY4hcHWvYX6gTHQuOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB7[XC{aX7hd5QucW6mdXPl[EBlgW6jbXnjJI1ie3NicnXkbZN1emmkdYTpc44h[W[2ZYKgNVAhdWmwczygTWM2OD1zOD62JO69VQ>? MmjxNlQ6ODB2NEe=
human U937 cells NVjIcot1WHKxbHnm[ZJifGmxbjDhd5NigQ>? MVm3NkBp MlvnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2StPEBie3OjeTygTWM2OD1{MDFOwG0> NHzvXYYyPzF3OEC1OC=>
mouse HT22 cells NVLVbpFYTnWwY4Tpc44h[XO|YYm= MW[zJIg> NVvsXVJtVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNidD3CU29JNWmwZIXj[YQhfG:6aXPpeJkh[XRiNECgeW0heHKnaX7jeYJifGWmIH\vdkA{KGi{czDmc4xtd3enZDDifUB1NUKRT1igbY5lfWO2aX;uJI1m[XO3cnXkJIFnfGW{IEmgbJJ{KGK7IF3UWEBie3OjeR?= M2fPWlI1OjR3OUO5
human THP1 cells M1\5TWZ2dmO2aX;uJIF{e2G7 M1S5WVIxKM7:TR?= MofRNUBp MX;Ec5dvemWpdXzheIlwdiCxZjDUVGEucW6mdXPl[EBPV1h{IH3SUmEh\XiycnXzd4lwdiCrbjDoeY1idiCWSGCxJINmdGy|IHH0JFIxKHWPIHnuZ5Vj[XSnZDDmc5IhOSCqcjDwdolweiC2bzDUVGEh[2ijbHzlcodmKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBTXC2SQ2KgZY5idHm|aYO= MU[yN|c5PjV{MB?=
MDA-MB-231 cells M4\zSWZ2dmO2aX;uJIF{e2G7 MlO5OUDPxE1? MV2xOkBp NHHPWpZKdmirYnn0bY9vKG:oIGDNRU1{fGmvdXzheIVlKE6ILXvhdJBiSiC|aXfuZYxqdmdiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gUWRCNU2ELUKzNUBk\WyuczDheEA2KHWPIHnuZ5Vj[XSnZDDmc5IhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M3Li[VI2OTlyNE[2
HL60 cells NFfDXmFRem:uaX\ldoF1cW:wIHHzd4F6 NHTSS4s{OCEQvF2= M1H3U|Q5KGh? NELFbodCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZQhOzBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UV{Bie3OjeR?= NHSyWpMyQDJ3OES0NC=>
Assay
Methods Test Index PMID
Western blot FADD / PARP / Cleaved PARP ; Caspase-3 / Cleaved Caspase-3 / Caspase-8 / Cleaved Caspase-8 ; ERK / p-ERK / JNK / p-JNK / p38 / p-p38 / Bax / Bcl-2 ; p-VEGFR2 / p-mTOR / pS6K1 / p70S6K1 / pAKT / AKT / MMP-2 / MMP-9 ; p21 / Survivin / Cyclin D1 ; DNMT1 / DMNT3A / DNMT3B ; TET1 / TET2 / TET3 30992674 23300633 30930986 30988303
Immunofluorescence 5-hmC 30988303
Growth inhibition assay Cell viability 30992674
In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 57 mg/mL
(199.13 mM)
Ethanol 3 mg/mL warmed
(10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Would you please suggest a suitable vehicle to dissolve Luteolin for in vivo i.p. use?

Answer:
Formula: 5% DMSO+40% PEG 300+5% Tween80+ddH2O, working Solution concentration: up to 7.5mg/ml, stable for 30min.

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