Dehydroepiandrosterone (DHEA)

Catalog No.S2604 Synonyms: Prasterone, Dehydroisoandrosterone

For research use only.

Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

Dehydroepiandrosterone (DHEA) Chemical Structure

CAS No. 53-43-0

Selleck's Dehydroepiandrosterone (DHEA) has been cited by 6 Publications

Purity & Quality Control

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Biological Activity

Description Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Targets
Androgen Receptor [1]
In vitro

Dehydroepiandrosterone (10-100 nM for 6-8 hours) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). Dehydroepiandrosterone also reduces NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) is higher than that of Dehydroepiandrosterone (10 nM). Dehydroepiandrosterone (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. [1] Dehydroepiandrosterone produces much greater levels of IL 2 than normals in response to stimulation. Dehydroepiandrosterone causes an enhanced capacity to secrete IL 2 following activation. Dehydroepiandrosterone augmentes IL 2 production by activated cloned T cell line. [2] Dehydroepiandrosterone increases the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion in primary cultures of mouse embryonic neocortical neurons. Dehydroepiandrosterone rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone regulates the motility and/or growth of neocortical neurons. [3]

In vivo Dehydroepiandrosterone, which results in plasma levels that resembled those in young adult humans, protects hippocampal CA1/2 neurons against unilateral infusions of 5 or 10 nmol of NMDA. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 57 mg/mL
(197.62 mM)
Water Insoluble
Ethanol '57 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5%DMSO+30% PEG300+5%Tween-80+ddH2O
For best results, use promptly after mixing.

8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 288.43
Formula

C19H28O2

CAS No. 53-43-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04355572 Not yet recruiting Drug: Vitamin D 4000IU daily|Drug: Placebo Polycystic Ovarian Syndrome in Adolescent Females|Vitamin D Deficiency Yale University January 1 2022 Not Applicable
NCT05126199 Not yet recruiting Other: Time restricted eating|Other: Normal ad libitum diet PCOS|Hyperinsulinemia|Insulin Resistance Ruairí Floyd|Tallaght University Hospital December 1 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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