For research use only.
Molecular Weight(MW): 288.43
Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Purity & Quality Control
Choose Selective Androgen Receptor Inhibitors
|Description||Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.|
Dehydroepiandrosterone (10-100 nM for 6-8 hours) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). Dehydroepiandrosterone also reduces NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) is higher than that of Dehydroepiandrosterone (10 nM). Dehydroepiandrosterone (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well.  Dehydroepiandrosterone produces much greater levels of IL 2 than normals in response to stimulation. Dehydroepiandrosterone causes an enhanced capacity to secrete IL 2 following activation. Dehydroepiandrosterone augmentes IL 2 production by activated cloned T cell line.  Dehydroepiandrosterone increases the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion in primary cultures of mouse embryonic neocortical neurons. Dehydroepiandrosterone rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone regulates the motility and/or growth of neocortical neurons. 
|In vivo||Dehydroepiandrosterone, which results in plasma levels that resembled those in young adult humans, protects hippocampal CA1/2 neurons against unilateral infusions of 5 or 10 nmol of NMDA. |
|In vitro||DMSO||57 mg/mL (197.62 mM)|
|Ethanol||57 mg/mL (197.62 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04310371||Not yet recruiting||Behavioral: 3-month lifestyle intervention||Obesity|Adolescent Obesity||University Hospital Clermont-Ferrand|Université d''Auvergne|LaPSCo laboratory Physiological and Psychosocial Stress UMR CNRS 6024 Clermont-Ferrand France|LaPEC laboratory (EA 4278) University of Avignon Avignon France|Child Medical Center 3 Rue de la Prugne 63540 Romagnat France|Tza-Nou Center 230 Rue Vercingétorix 63150 La Bourboule France||September 2020||Not Applicable|
|NCT04355572||Not yet recruiting||Drug: Vitamin D 4000IU daily|Drug: Placebo||Polycystic Ovarian Syndrome in Adolescent Females|Vitamin D Deficiency||Yale University||July 2020||Not Applicable|
|NCT04334083||Not yet recruiting||Behavioral: Comparison of biomarkers of stress||Heart Rate Variability||University Hospital Clermont-Ferrand||June 2020||Not Applicable|
|NCT04146389||Not yet recruiting||--||Hyperprolactinemia||University Hospital Inselspital Berne||March 2020||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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