Dehydroepiandrosterone (DHEA)

For research use only.

Catalog No.S2604

1 publication

Dehydroepiandrosterone (DHEA) Chemical Structure

Molecular Weight(MW): 288.43

Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

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Selleck's Dehydroepiandrosterone (DHEA) has been cited by 1 publication

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Biological Activity

Description Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Androgen Receptor [1]
In vitro

Dehydroepiandrosterone (10-100 nM for 6-8 hours) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). Dehydroepiandrosterone also reduces NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) is higher than that of Dehydroepiandrosterone (10 nM). Dehydroepiandrosterone (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. [1] Dehydroepiandrosterone produces much greater levels of IL 2 than normals in response to stimulation. Dehydroepiandrosterone causes an enhanced capacity to secrete IL 2 following activation. Dehydroepiandrosterone augmentes IL 2 production by activated cloned T cell line. [2] Dehydroepiandrosterone increases the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion in primary cultures of mouse embryonic neocortical neurons. Dehydroepiandrosterone rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone regulates the motility and/or growth of neocortical neurons. [3]

In vivo Dehydroepiandrosterone, which results in plasma levels that resembled those in young adult humans, protects hippocampal CA1/2 neurons against unilateral infusions of 5 or 10 nmol of NMDA. [1]


Solubility (25°C)

In vitro DMSO 57 mg/mL (197.62 mM)
Ethanol 57 mg/mL (197.62 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+30% PEG300+5%Tween-80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 288.43


CAS No. 53-43-0
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04310371 Not yet recruiting Behavioral: 3-month lifestyle intervention Obesity|Adolescent Obesity University Hospital Clermont-Ferrand|Université d''Auvergne|LaPSCo laboratory Physiological and Psychosocial Stress UMR CNRS 6024 Clermont-Ferrand France|LaPEC laboratory (EA 4278) University of Avignon Avignon France|Child Medical Center 3 Rue de la Prugne 63540 Romagnat France|Tza-Nou Center 230 Rue Vercingétorix 63150 La Bourboule France September 2020 Not Applicable
NCT04355572 Not yet recruiting Drug: Vitamin D 4000IU daily|Drug: Placebo Polycystic Ovarian Syndrome in Adolescent Females|Vitamin D Deficiency Yale University July 2020 Not Applicable
NCT04334083 Not yet recruiting Behavioral: Comparison of biomarkers of stress Heart Rate Variability University Hospital Clermont-Ferrand June 2020 Not Applicable
NCT04146389 Not yet recruiting -- Hyperprolactinemia University Hospital Inselspital Berne March 2020 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID