Dehydroepiandrosterone (DHEA)

For research use only.

Catalog No.S2604 Synonyms: Prasterone, Dehydroisoandrosterone

3 publications

Dehydroepiandrosterone (DHEA) Chemical Structure

CAS No. 53-43-0

Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

Selleck's Dehydroepiandrosterone (DHEA) has been cited by 3 publications

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Biological Activity

Description Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Targets
Androgen Receptor [1]
In vitro

Dehydroepiandrosterone (10-100 nM for 6-8 hours) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). Dehydroepiandrosterone also reduces NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) is higher than that of Dehydroepiandrosterone (10 nM). Dehydroepiandrosterone (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. [1] Dehydroepiandrosterone produces much greater levels of IL 2 than normals in response to stimulation. Dehydroepiandrosterone causes an enhanced capacity to secrete IL 2 following activation. Dehydroepiandrosterone augmentes IL 2 production by activated cloned T cell line. [2] Dehydroepiandrosterone increases the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion in primary cultures of mouse embryonic neocortical neurons. Dehydroepiandrosterone rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone regulates the motility and/or growth of neocortical neurons. [3]

In vivo Dehydroepiandrosterone, which results in plasma levels that resembled those in young adult humans, protects hippocampal CA1/2 neurons against unilateral infusions of 5 or 10 nmol of NMDA. [1]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (197.62 mM)
Water Insoluble
Ethanol '57 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+30% PEG300+5%Tween-80+ddH2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 288.43
Formula

C19H28O2

CAS No. 53-43-0
Storage powder
in solvent
Synonyms Prasterone, Dehydroisoandrosterone
Smiles CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05033444 Not yet recruiting Drug: PRV-002|Drug: Placebo Traumatic Brain Injury (TBI) Odyssey Group International Inc.|Avance Clinical Pty Ltd. September 2021 Phase 1
NCT04989972 Not yet recruiting Drug: PSIL428|Dietary Supplement: Oyster mushroom Anxiety and Depression Wake Network Inc.|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI September 15 2021 Phase 2
NCT04982692 Not yet recruiting Drug: intravaginal prasterone|Drug: Placebo ovules Postmenopausal Vulvovaginal Atrophy Lee''s Pharmaceutical Limited July 31 2021 Phase 3

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Androgen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID