Andarine

For research use only.

Catalog No.S1140 Synonyms: GTx-007, S-4

6 publications

Andarine Chemical Structure

CAS No. 401900-40-1

Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.

Selleck's Andarine has been cited by 6 publications

Purity & Quality Control

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Biological Activity

Description Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.
Targets
Androgen Receptor [1]
4 nM(Ki)
In vitro

Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM. [1]

In vivo Andarine exhibits potent and efficacious anabolic activity and results in dose-dependent stimulation of growth in prostate, seminal vesicles, and levator ani muscle with the ED50 of 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively. Besides, Andarine shows no dose-dependent effect on castration-induced change in FSH, and partially suppresses LH production at dose rates of 0.5 mg/day or higher. [1] In dogs administrated by intravenous doses of Andarine (0.1, 1, 3, and 10 mg/kg), the total body clearance (CL) ranged from 7.4 mL/min/kg to 3.1 mL/min/kg, volume of distribution at steady state (Vss) is 1.39 L/kg and half-life of Andarine is 229 minutes, respectively. In addition, oral bioavailability is 38%, 62% and 91% for the 10 mg/kg, 1 mg/kg and 0.1 mg/kg doses, respectively. [2] Andarine demonstrates tissue-selective pharmacological activity and significantly decreased prostate weight to 79.4% at a concentration of 0.5 mg/day in intact rats. [3]

Protocol

Animal Research:[1]
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  • Animal Models: Male Sprague-Dawley rats and castrated rat model.
  • Dosages: ≤1 mg/day
  • Administration: Administered via osmotic pump.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 88 mg/mL (199.38 mM)
Ethanol 88 mg/mL (199.38 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 441.36
Formula

C19H18F3N3O6

CAS No. 401900-40-1
Storage powder
in solvent
Synonyms GTx-007, S-4
Smiles CC(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04577599 Recruiting Other: Mobile Low-dose Computed Tomography (LDCT) Screening Lung Neoplasms|Lung Cancer Daniel Carrizosa|Leon Levine Foundation|Atrium Health January 6 2021 Not Applicable
NCT04572906 Recruiting Combination Product: NTX-001 Peripheral Nerve Injuries Neuraptive Therapeutics Inc. September 25 2020 Phase 2
NCT03938077 Withdrawn Device: Storytelling 4 Empowerment HIV/AIDS and Infections|Drug Abuse|Adolescent Behavior|Drug Usage|Alcohol Use|Mental Health|Tobacco Use|HIV Testing University of Michigan October 1 2019 Not Applicable
NCT04099173 Active not recruiting Behavioral: Brief Mindfulness Based Intervention Suicidal Ideation|Psychiatric Disorder|Addiction VA Salt Lake City Health Care System September 1 2019 Not Applicable
NCT03150511 Recruiting Drug: Tesamorelin 2 Milligrams (MG)|Drug: Placebo Peripheral Nerve Injuries Johns Hopkins University|United States Department of Defense June 1 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Androgen Receptor Signaling Pathway Map

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