E3 Ligase Inhibitors

Catalog No.	Product Name	Information
E5877	LYG-409	LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.
E5839	OICR-8268	OICR-8268 is a potent, reversible and in-cell active DCAF1 ligand. It significantly binds to DCAF1 WDR domain with an Kd value of 38 nM. It serves as a promising starting point for developing chemical handles for DCAF1-based PROTACs targeting selective protein degradation as well as cancer therapeutics.
E5844	NSC2805	NSC2805 is a potent inhibitor of WWP2 ubiquitin ligase with an IC50 of 0.38 μM. It is used in cancer research for studying WWP2-associated pathways.
F2194	Cullin 1/CUL-1 Rabbit mAb	CUL1,CUL-1,Cullin 1,Cullin 1/CUL-1
F1516	PIAS3 Rabbit mAb
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