New E3 Ligase Inhibitors

Catalog No. Product Name Information
E5877 LYG-409 LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.
E5839 OICR-8268 OICR-8268 is a potent, reversible and in-cell active DCAF1 ligand. It significantly binds to DCAF1 WDR domain with an Kd value of 38 nM. It serves as a promising starting point for developing chemical handles for DCAF1-based PROTACs targeting selective protein degradation as well as cancer therapeutics.
E5844 NSC2805 NSC2805 is a potent inhibitor of WWP2 ubiquitin ligase with an IC50 of 0.38 μM. It is used in cancer research for studying WWP2-associated pathways.
F2194 Cullin 1/CUL-1 Rabbit mAb CUL1,CUL-1,Cullin 1,Cullin 1/CUL-1
F1516 PIAS3 Rabbit mAb
All E3 Ligase Inhibitors