New GPR Modulators

Catalog No.	Product Name	Information
E6738	BCFTP	BCFTP is a potent, orally active, selective positive allosteric modulator (PAM) of human MrgprX1 that enhances endogenous ligand signaling to inhibit spinal C-fibre nociceptive transmission, thereby relieving heat hyperalgesia and spontaneous pain in neuropathic models without itch or tolerance.
E6509	AR420626	AR420626 is a selective agonist of FFAR3 (GPR41) with an IC50 of 117 nM, that prevents serotonin-induced circular muscle relaxation ex vivo and defecation in vivo.
E1162	GLPG0974	GLPG0974 is a potent and selective antagonist of the human free fatty acid receptor 2 (FFA2/GPR43) with an IC50 of 9 nM and also inhibits SCFA‐induced neutrophil activation and migration.
E1928	Azelaprag	Azelaprag (AMG 986) is a potent agonist of apelin receptor (APJ) with an EC50 of 0.32 nM. It exhibits potential and can be used in Heart failure (HF) research.
≡ All GPR Modulators