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GlyR Inhibitors/Agonists | Antagonists

GlyR Products

  • All (4)
  • GlyR Inhibitor (1)
  • GlyR Antagonists (2)
  • GlyR Agonist (1)
  • New GlyR Products
Cat.No. Product Name Information Product Use Citations Product Validations
S0920 Ginkgolide J Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. This compound also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. It exhibits anti‑inflammatory activity.
S9294 Gelsemine Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine.
S6100 Picrotoxin Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S6172 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
Sci Rep, 2023, 13(1):18492.
S0920 Ginkgolide J Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. This compound also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. It exhibits anti‑inflammatory activity.
S6100 Picrotoxin Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S6172 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
Sci Rep, 2023, 13(1):18492.
S9294 Gelsemine Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine.