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Anti-Prostaglandin D Synthase (Lipocalin)/PDS Rabbit Antibody [A1L2]

Catalog No.: F2844

Application: Reactivity: Human

Usage Information

Dilution
WB1:10000 IHC1:200 IF1:200

Application
WB, IHC, IF

Reactivity
Human

Source
Rabbit

Storage Buffer
PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3

Storage (from the date of receipt)
-20°C (avoid freeze-thaw cycles), 2 years

Predicted MW Observed MW
21 kDa 28 kDa
^*Why do the predicted and actual molecular weights differ? The following reasons may explain differences between the predicted and actual protein molecular weight.

Datasheet & SDS

Biological Description

Specificity
Anti-Prostaglandin D Synthase (Lipocalin)/PDS Rabbit Antibody [A1L2] detects endogenous levels of total -Prostaglandin D Synthase (Lipocalin)/PDS protein.

Clone
A1L2

Synonym(s)
PDS, PTGDS, Prostaglandin-H2 D-isomerase, Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, L-PGDS, PGD2 synthase, PGDS, PGDS2

Background
Prostaglandin D Synthase (Lipocalin)/PDS, also known as β-trace protein, is a unique member of the lipocalin family that functions both as an enzyme and a transporter of lipophilic molecules. Structurally, it possesses the typical lipocalin β-barrel fold with a central hydrophobic cavity that accommodates diverse ligands, and it catalyzes the isomerization of prostaglandin H2 (PGH2) into prostaglandin D2 (PGD2) via its catalytic cysteine (Cys65). Prostaglandin D Synthase (Lipocalin)/PDS is widely expressed in the central nervous system, heart, and male reproductive organs, and is secreted into cerebrospinal fluid, plasma, and seminal plasma. Functionally, it produces PGD2, a key lipid mediator regulating sleep, pain sensation, inflammation, immunity, cardiovascular function, and reproduction, while also acting as a transporter for retinoids, thyroid hormones, bile pigments, gangliosides, heme, NAD(P)H, and amyloid β peptides, the latter linking it to neuroprotection by preventing amyloid aggregation. This dual enzymatic and carrier role distinguishes Prostaglandin D Synthase (Lipocalin)/PDS as a multifunctional protein with important physiological and pathophysiological relevance.

Background

Prostaglandin D Synthase (Lipocalin)/PDS, also known as β-trace protein, is a unique member of the lipocalin family that functions both as an enzyme and a transporter of lipophilic molecules. Structurally, it possesses the typical lipocalin β-barrel fold with a central hydrophobic cavity that accommodates diverse ligands, and it catalyzes the isomerization of prostaglandin H2 (PGH2) into prostaglandin D2 (PGD2) via its catalytic cysteine (Cys65). Prostaglandin D Synthase (Lipocalin)/PDS is widely expressed in the central nervous system, heart, and male reproductive organs, and is secreted into cerebrospinal fluid, plasma, and seminal plasma. Functionally, it produces PGD2, a key lipid mediator regulating sleep, pain sensation, inflammation, immunity, cardiovascular function, and reproduction, while also acting as a transporter for retinoids, thyroid hormones, bile pigments, gangliosides, heme, NAD(P)H, and amyloid β peptides, the latter linking it to neuroprotection by preventing amyloid aggregation. This dual enzymatic and carrier role distinguishes Prostaglandin D Synthase (Lipocalin)/PDS as a multifunctional protein with important physiological and pathophysiological relevance.

References
https://pubmed.ncbi.nlm.nih.gov/20667974/ https://pubmed.ncbi.nlm.nih.gov/34744762/

Reference Table for Selecting PVDF Membrane Pore Size Specifications

Protein Size (kDa)	PVDF Transfer Membrane Pore Size (μm)
< 10	0.22
10-20	0.22
20-30	0.45
30-45	0.45
45-70	0.45
80-100	0.45
100-140	0.45
> 140	0.45

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Protein Size (kDa)	Separating Gel Percentage
4-40	20%
12-45	15%
10-70	12.5%
15-100	10%
25-100	8%
60-210	5%