Anti-Prostaglandin D Synthase (Lipocalin)/PDS Rabbit Antibody [A1L2]

Catalog No.: F2844

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Biological Description

Specificity Anti-Prostaglandin D Synthase (Lipocalin)/PDS Rabbit Antibody [A1L2] detects endogenous levels of total -Prostaglandin D Synthase (Lipocalin)/PDS protein.
Background Prostaglandin D Synthase (Lipocalin)/PDS, also known as β-trace protein, is a unique member of the lipocalin family that functions both as an enzyme and a transporter of lipophilic molecules. Structurally, it possesses the typical lipocalin β-barrel fold with a central hydrophobic cavity that accommodates diverse ligands, and it catalyzes the isomerization of prostaglandin H2 (PGH2) into prostaglandin D2 (PGD2) via its catalytic cysteine (Cys65). Prostaglandin D Synthase (Lipocalin)/PDS is widely expressed in the central nervous system, heart, and male reproductive organs, and is secreted into cerebrospinal fluid, plasma, and seminal plasma. Functionally, it produces PGD2, a key lipid mediator regulating sleep, pain sensation, inflammation, immunity, cardiovascular function, and reproduction, while also acting as a transporter for retinoids, thyroid hormones, bile pigments, gangliosides, heme, NAD(P)H, and amyloid β peptides, the latter linking it to neuroprotection by preventing amyloid aggregation. This dual enzymatic and carrier role distinguishes Prostaglandin D Synthase (Lipocalin)/PDS as a multifunctional protein with important physiological and pathophysiological relevance.

Usage Information

Application WB, IHC, IF Dilution
WB IHC IF
1:10000 1:200 1:200
Reactivity Human
Source Rabbit MW 21 kDa
Storage Buffer PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
Storage
(from the date of receipt)		 -20°C (avoid freeze-thaw cycles), 2 years

References

  • https://pubmed.ncbi.nlm.nih.gov/20667974/
  • https://pubmed.ncbi.nlm.nih.gov/34744762/

Application Data