CaSR
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1260 | Cinacalcet HCl | <1 mg/mL | 79 mg/mL | 33 mg/mL |
| S2633 | NPS-2143 | <1 mg/mL | 82 mg/mL | <1 mg/mL |
CaSR Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1260 |
Cinacalcet HClCinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism. |
A. SK-N-LP cells stably transfected with pCMV-GFP or pCMV-CaSR-GFP were grown in serum deprivation media for 16 hours. They were then exposed to cinacalcet for 24 hours at indicated doses in the same media containing 0.5 mM CaCl2 . Total proteins were isolated from floating and adherent cells to conduct immunoblots.
|
|
| S2633 |
NPS-2143NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. |
The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1260 |
Cinacalcet HClCinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism. |
2018, 1864(11):3585-3594 2018, 10.1002/jbmr.3643 2016, 7(13):16112-29 |
A. SK-N-LP cells stably transfected with pCMV-GFP or pCMV-CaSR-GFP were grown in serum deprivation media for 16 hours. They were then exposed to cinacalcet for 24 hours at indicated doses in the same media containing 0.5 mM CaCl2 . Total proteins were isolated from floating and adherent cells to conduct immunoblots.
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2633 |
NPS-2143NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. |
2016, 10.1007/s00204-016-1693-z 2014, 289(42):28835-45 |
The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).
|
