Home GPCR & G Protein CaSR

CaSR

Other GPCR & G Protein Related Inhibitors

Hedgehog/Smoothened PKA CGRP Receptor Endothelin Receptor S1P Receptor Cannabinoid Receptor SGLT Opioid Receptor GPR CCR
Cat.No. Product Name Information Product Use Citations Product Validations
S2633 NPS-2143 NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.
Biomed Pharmacother, 2023, 163:114843
Toxins (Basel), 2023, 16(1)21
Kaohsiung J Med Sci, 2022, 10.1002/kjm2.12601
Verified customer review of NPS-2143
S1260 Cinacalcet (AMG-073) HCl Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.
Int J Mol Sci, 2022, 23(8)4323
Int J Mol Sci, 2020, 21(20)E7617
Mol Cell Endocrinol, 2020, 501:110654
Verified customer review of Cinacalcet (AMG-073) HCl
E0359 Evocalcet Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). This compound (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.

Signaling Pathway Map