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CaSR

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Cat.No. Product Name Information Product Use Citations Product Validations
S2633 NPS-2143 NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.
Frontiers in Immunology, October 21, 2021, 748497
Frontiers in Pharmacology, October 11, 2018, 1163
Scientific Reports, May 02, 2017, 1313
Verified customer review of NPS-2143
S1260 Cinacalcet (AMG-073) HCl Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.
Int J Mol Sci, 2022, 23(8)4323
Int J Mol Sci, 2020, 21(20)E7617
Mol Cell Endocrinol, 2020, 501:110654
Verified customer review of Cinacalcet (AMG-073) HCl
E0359 Evocalcet Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). This compound (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.

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