Blog of Signaling Pathways

Optimizing ganciclovir and valganciclovir dosing regimens in pediatric patients with cytomegalovirus infection: a spotlight on therapeutic drug monitoring

31 views | Mar 10 2023

Therapeutic drug monitoring (TDM) has the potential to improve the efficacy and safety of ganciclovir/valganciclovir use in pediatrics, but further studies are necessary to establish optimal dosing regimens and evaluate the clinical impact of TDM. [Read the Full Post]

Treatment of Congenital Cytomegalovirus and Ganciclovir Therapeutic Drug Monitoring in Twin Preterm Infants

24 views | Mar 10 2023

The case report highlights the importance of individualized treatment and close monitoring in premature infants with congenital cytomegalovirus infection, and the use of therapeutic drug monitoring to adapt to their evolving physiologic maturation. [Read the Full Post]

Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level

95 views | Mar 10 2023

Understanding early events in sickle cell disease pathogenesis associated with the presence of hemoglobin S is crucial for identifying new targets for treatment, including reducing HbS levels, reducing the impact of HbS polymers, and targeting membrane events, and exploiting the unique permeability of sickle cells for developing targeted therapies. [Read the Full Post]

DTIC (nsc-45388) and combination therapy for melanoma. I. Studies with DTIC, BCNU (NSC-409962), CCNU (NSC-79037), vincristine (NSC-67574), and hydroxyurea (NSC-32065)

53 views | Mar 10 2023

The study found that combination chemotherapy regimens can improve response rates and survival times in patients with metastatic malignant melanoma, but careful monitoring of toxicity is necessary and treatment decisions should be individualized based on the patient's clinical profile. [Read the Full Post]

Kaempferol inhibits airway inflammation induced by allergic asthma through NOX4-Mediated autophagy

59 views | Mar 10 2023

Kaempferol binds to NOX4 and inhibits NOX4-mediated autophagy, providing an effective therapeutic strategy for treating asthma by decreasing NOX4 expression and improving airway inflammation and remodeling. [Read the Full Post]

Concentration dependence of active potassium transport in the human red blood cell in the presence of inhibitors

125 views | Mar 09 2023

The passage describes the inhibition of active potassium influx in human red blood cells by several compounds, including strophanthidin, ethacrynic acid, and MK-870, and suggests a model for the behavior of the transport system in the presence of these compounds and potassium ions. [Read the Full Post]

Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health

81 views | Mar 09 2023

Enhancing oligodendrocyte activity with the pharmaceutical drug Clemastine can prevent the chronic decline of microelectrode recording performance and improve the integration of functional device interfaces with brain tissue over a long period of time. [Read the Full Post]

Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice

66 views | Mar 09 2023

This study suggests that the lysophosphatidylcholine-induced IC demyelination mouse model is useful for evaluating the effects of pharmacological treatments that promote remyelination on motor function and histological changes. [Read the Full Post]

Effect of hybrid compounds of stilbene and pentadienone on inhibition of tubulin polymerization

116 views | Mar 09 2023

The study designed and synthesized hybrid compounds with excellent anticancer properties that inhibit tubulin polymerization and induce cell cycle arrest in MDA-MB-231 human breast cancer cells. [Read the Full Post]

Evaluation of cytomegalovirus infection/disease in IgG positive renal transplantation recipients on valaciclovir prophylaxis

42 views | Mar 09 2023

This study found that valacyclovir may be a preferable prophylaxis for CMV infection in renal transplant recipients due to its efficacy and fewer side effects compared to valganciclovir. [Read the Full Post]

Clinical Characteristics and Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

83 views | Mar 08 2023

Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematological malignancy with diverse clinical manifestations and poor prognosis that requires a combination of clinical, morphological and immunophenotypic features for diagnosis and individualized treatment. [Read the Full Post]

Hypoxia-induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells

120 views | Mar 08 2023

The study suggests that hypoxia-induced YAP activation is positively associated with mesenchymal TNBC cell migration and may be a novel factor responsible for promoting the aggressive behavior of TNBC cells under hypoxic conditions. [Read the Full Post]

Impacts of Statin Therapy Strategies on Incidence of Ischemic Cerebrovascular Events in Patients With Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Bayesian Network Meta-Analysis

31 views | Mar 08 2023

The Bayesian network meta-analysis and systematic review suggest that statins can significantly improve functional prognosis and reduce the incidence of ischemic cerebrovascular events in patients with aSAH, with pravastatin (40 mg/d) being the most effective type of statin. [Read the Full Post]

Assessment of the regenerative potential of macro-porous chitosan-calcium simvastatin scaffolds on bone cells

101 views | Mar 08 2023

The study evaluated the bioactive potential of a macro-porous chitosan scaffold incorporated with calcium hydroxide and functionalized with bioactive doses of simvastatin for bone tissue regeneration, demonstrating increased bioactivity and promising potential. [Read the Full Post]

Metabolic characterization and GAPDH dependent regulation of ENaC in hPheo1 wild-type and SDHB knockdown cells

58 views | Mar 08 2023

The study investigates the expression and activity of ENaC and ASIC ion channels in hPheo1 WT and SDHB KD cells, which may provide important insights into understanding and treating SDHB-related disease. [Read the Full Post]

In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs

108 views | Mar 07 2023

The study used mouse hypothermia as an in vivo screen for adenosinergic effects and identified several drugs that interact with adenosine receptors (ARs) in different ways, suggesting potential for repurposing and highlighting the importance of considering multiple mechanisms of action and potential off-target effects. [Read the Full Post]

Effects of atomoxetine plus a hypnotic on obstructive sleep apnea severity in patients with a moderately collapsible pharyngeal airway

54 views | Mar 07 2023

The study found that the combination of atomoxetine and trazodone (Ato-Trazo) reduced obstructive sleep apnea severity without reducing the arousal threshold, but worsened subjective sleep quality. [Read the Full Post]

Chemotherapeutic Activity of Pitavastatin in Vincristine Resistant B-Cell Acute Lymphoblastic Leukemia

59 views | Mar 07 2023

The study suggests that pitavastatin may have potential as a repurposed chemotherapeutic agent for vincristine-resistant B-cell acute lymphoblastic leukemia. [Read the Full Post]

HLA-haploidentical hematopoietic stem cells transplantation with regulatory and conventional T-cell adoptive immunotherapy in pediatric patients with very high-risk acute leukemia

71 views | Mar 07 2023

The study reports promising outcomes of a novel HLA-haploidentical hematopoietic stem cell transplantation strategy with adoptive immunotherapy in pediatric patients with high-risk acute leukemia who lack an HLA-matched donor. [Read the Full Post]

Results from a phase I/II trial of cusatuzumab combined with azacitidine in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive chemotherapy

102 views | Mar 07 2023

The phase I/II trial showed that cusatuzumab plus azacitidine was generally well-tolerated and showed preliminary efficacy in newly diagnosed AML patients ineligible for intensive chemotherapy, with ongoing investigation into the combination with venetoclax and azacitidine. [Read the Full Post]