NMDAR

The role of glutamate NMDA receptors of the mediodorsal thalamus in scopolamine-induced amnesia in rats

26 views | Feb 11 2024

This study demonstrates that activation of glutamate NMDA receptors in the mediodorsal thalamus mitigates scopolamine-induced memory impairment, while their blockade exacerbates this cognitive deficit, suggesting a pivotal role for the MD glutamatergic system via the NMDA receptor pathway in memory consolidation. [Read the Full Post]

Integrative Pharmacology in the Treatment of Substance Use Disorders

20 views | Feb 05 2024

Navigating the intricate web of neurobiological pathways, an integrated approach targeting KYNA-NMDA-α7nAChRcentric pathophysiology presents a promising avenue for developing novel combination treatments to address substance use disorders comprehensively. [Read the Full Post]

Lorazepam in catatonia - Past, present and future of a clinical success story

52 views | Mar 14 2023

This passage discusses the history, effectiveness, and potential future directions for the use of lorazepam in the treatment of catatonia, emphasizing the importance of empirical observation and clinical practice, while also calling for further scientific investigation. [Read the Full Post]

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

0 views | Dec 28 2018

Li D et al. indicated that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling. [Read the Full Post]

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

2422 views | Sep 21 2017

Li D et al. indicated that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling. [Read the Full Post]

Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

0 views | Apr 10 2017

Li Z et al found that the NMDA receptor-mediated ERK-CREB signaling pathway might participates in Res-induced neuroprotection in rats with focal cerebral ischemia. [Read the Full Post]