Blog of Signaling Pathways

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

0 views | Aug 05 2023

Co-inhibition of HDAC6 and HDAC8 with selective inhibitors synergistically suppresses cancer cell proliferation, enhances apoptosis, and inhibits metastasis in p53 wild-type ovarian cancer cells, indicating a potential novel therapeutic approach for ovarian cancer. [Read the Full Post]

Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis

30 views | Aug 05 2023

Lyso-Gb3 induces necroptosis via autophagy and contributes to endothelial dysfunction in Fabry disease. [Read the Full Post]

Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

48 views | Aug 05 2023

The study found that matrix stiffness influences the formation of invasive protrusions in mammary acini, with increased MRTF-A activity observed on stiff matrices, highlighting the intricate interplay between matrix properties and transcription factors in mammary gland development. [Read the Full Post]

Progress in on-line, at-line, and in-line coupling of sample treatment with capillary and microchip electrophoresis over the past 10 years: A review

87 views | Aug 05 2023

The review evaluates the progress of on-line, at-line, and in-line sample treatment coupled with capillary and microchip electrophoresis over the past decade, focusing on the development of flow-gating interfaces, the coupling of extraction techniques, and the design of sequential analyzers, with applications in studying living organisms and monitoring substances in diverse samples. [Read the Full Post]

Prostate cancer cell‑derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K/AKT/mTOR pathway

83 views | Aug 04 2023

Spondin 2 promotes osteogenesis in prostate cancer by activating the PI3K/AKT/mTOR pathway and involving the integrin receptor α5β1. [Read the Full Post]

Modulation of gene expression on a transcriptome-wide level following human neural stem cell transplantation in aged mouse stroke brains

21 views | Aug 04 2023

This study demonstrates that transplantation of human neural stem cells (NSCs) in aged mice after stroke reduces infarct size, modulates proinflammatory factors and matrix metalloproteases, and induces differential expression of genes and pathways associated with neuroinflammation, cell adhesion, and matrix remodeling. [Read the Full Post]

Transformable prodrug nanoplatform via tumor microenvironment modulation and immune checkpoint blockade potentiates immunogenic cell death mediated cancer immunotherapy

78 views | Aug 04 2023

In this study, a dual-responsive polymersomal prodrug nanoplatform was developed, combining CAF inhibition, ROS consumption, immune checkpoint blockade, and immunogenic cell death induction, leading to improved tumor regression and long-term immune memory response, offering potential for effective cancer treatment. [Read the Full Post]

Targeting VPS34 in autophagy: An update on pharmacological small-molecule compounds

22 views | Aug 04 2023

This review summarizes the molecular structure, functions, and associations of VPS34 with human diseases, while also discussing the potential of small molecule inhibitors targeting VPS34 for future targeted drug development. [Read the Full Post]

Antiparasitic Activity of Plumbago auriculata Extracts and Its Naphthoquinone Plumbagin against Trypanosoma cruzi

32 views | Aug 04 2023

The study demonstrates the potent antiparasitic activity of Plumbago auriculata crude extracts and its naphthoquinone Plumbagin against different forms and strains of Trypanosoma cruzi, suggesting their potential as promising alternatives for Chagas disease treatment. [Read the Full Post]

Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control

52 views | Aug 03 2023

This study identified multiple metabolites, including hydroxylated and glucuronic acid conjugated forms, for the hypoxia-inducible factor-prolyl hydroxylase inhibitor compounds BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes, shedding light on their metabolic pathways and potential misuse as performance enhancers. [Read the Full Post]

NAD + Metabolism Generates a Metabolic Vulnerability in Endocrine-Resistant Metastatic Breast Tumors in Females

112 views | Aug 03 2023

The study revealed that combining a NAMPT inhibitor with fulvestrant showed a synergistic effect in reducing metastatic tumor burden and reversing gene expression associated with aggressive tumor phenotypes in ER+ metastatic breast cancer, offering a promising strategy for treatment. [Read the Full Post]

BMP-1-induced GBA1 nuclear accumulation provokes CCN2 mRNA expression via importin-β-mediated nucleocytoplasmic pathway

42 views | Aug 03 2023

The study demonstrated that bone morphogenetic protein-1 (BMP-1) promotes the nuclear accumulation of glucosylceramidase (GBA1) by reducing α2,6-sialylation, which subsequently affects the expression of cellular communication network factor 2 (CCN2) and provides insights into the role of the BMP-1-GBA1-CCN2 axis in dental and craniofacial diseases. [Read the Full Post]

VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis

67 views | Aug 03 2023

This study demonstrates the potential of VH298-loaded extracellular vesicles (EVs) and GelMA hydrogel as a promising therapeutic strategy for diabetic wound treatment, promoting angiogenesis and enhancing wound healing. [Read the Full Post]

Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor

33 views | Aug 03 2023

The study demonstrated that co-administration of a GLUT1 inhibitor and docetaxel synergistically increased cytotoxicity and apoptosis in lung cancer cells, suggesting a promising therapeutic strategy for the treatment of lung cancer patients. [Read the Full Post]

Effects of Hypolipidemic Drugs on Psoriasis

92 views | Aug 02 2023

The systematic review of 41 original articles assessed the effect of different hypolipidemic treatments on the course of psoriasis, highlighting the potential benefits of statins, fibrates, glitazones, and GLP-1 receptor agonists in improving lipid abnormalities associated with the disease. [Read the Full Post]

Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agents

81 views | Aug 02 2023

This study utilized integrated statistics and bioinformatics approaches to identify key genes, transcriptional regulators, and candidate therapeutic agents for colorectal cancer (CRC), highlighting their potential diagnostic, prognostic, and therapeutic significance. [Read the Full Post]

Increased CMV disease and "severe" BK viremia with belatacept vs. sirolimus three-drug maintenance immunosuppression

42 views | Aug 02 2023

The study found that belatacept therapy in kidney transplant recipients was associated with a higher risk of CMV disease and "severe" CMV and BK viremia, but did not significantly increase overall infection incidence and showed comparable rates of acute rejection and graft loss at 12 months compared to sirolimus therapy. [Read the Full Post]

KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma

73 views | Aug 02 2023

The study demonstrated that the overexpression of KIF11 in adrenocortical carcinoma (ACC) is associated with poor prognosis and suggests that KIF11 may serve as a potential therapeutic target for ACC. [Read the Full Post]

Liver Fibrosis, Fat, and Iron Evaluation with MRI and Fibrosis and Fat Evaluation with US: A Practical Guide for Radiologists

72 views | Aug 02 2023

This review provides a practical guide for radiologists on the interpretation of liver disease using MRI and US, focusing on quantitative imaging biomarkers such as liver fibrosis, fat, and iron, and covering technical requirements, measurement techniques, case interpretation guidelines, and potential pitfalls. [Read the Full Post]

Mivebresib alleviates systemic lupus erythematosus-associated diffuse alveolar hemorrhage via inhibiting infiltration of monocytes and M1 polarization of macrophages

40 views | Aug 01 2023

Mivebresib, a BRD4 inhibitor, demonstrates potential as a therapeutic option for diffuse alveolar hemorrhage associated with systemic lupus erythematosus by inhibiting macrophage polarization and inflammatory cell infiltration. [Read the Full Post]