ATP-citrate lyase

[ANMCO Expert opinion: Bempedoic acid place in therapy for hypercholesterolemia management]

40 views | Oct 24 2023

Bempedoic acid, a newly approved therapeutic option for hypercholesterolemia, offers a hepatic selective action that reduces the risk of muscle adverse effects, making it particularly useful in certain clinical settings according to an ANMCO document. [Read the Full Post]

ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model

72 views | Sep 05 2023

The ACL inhibitor BMS-303141 effectively attenuated ectopic lipid accumulation and improved renal injuries in db/db mice, suggesting its potential as a therapeutic treatment for obesity-related renal complications. [Read the Full Post]

Inhibition of ACLY Leads to Suppression of Osteoclast Differentiation and Function Via Regulation of Histone Acetylation

21 views | Dec 09 2022

Qian Guo et al. proved that inhibition of ATP-citrate lyase led to suppression of osteoclast differentiation and function via regulation of histone acetylation. [Read the Full Post]