Actin

Plasmodium falciparum formins are essential for invasion and sexual stage development

39 views | Feb 16 2024

"By elucidating the distinct roles of Plasmodium falciparum formins 1 and 2 (FRM1 and FRM2) in various stages of the malaria parasite's lifecycle and demonstrating the efficacy of the small molecule inhibitor SMIFH2 in blocking multiple stages of parasite development, this research presents promising avenues for targeted intervention and a deeper comprehension of malaria pathogenesis." [Read the Full Post]

Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

33 views | Jan 07 2024

A comprehensive screening of 74 compounds related to CK-666 revealed two potent Arp2/3 inhibitors, compounds 59 and 69, which displayed improved in vivo efficiency despite being slightly less effective in vitro, validating original assays for Arp2/3 activity while offering promising candidates for further study. [Read the Full Post]