Blog of Signaling Pathways

Purine Antimetabolites associated Pneumocystis Jiroveci Pneumonia

132 views | Oct 20 2023

The retrospective disproportionality analysis of the FDA Adverse Event Reporting System (FAERS) database revealed a significant safety signal for pneumocystis jiroveci pneumonia (PJP) associated with purine antimetabolites, particularly fludarabine and thioguanine, among populations with autoimmune disorders and cancer. [Read the Full Post]

Assessment of verdinexor as a canine P-glycoprotein substrate

20 views | Oct 20 2023

Verdinexor has been determined to not be a substrate for canine P-gp based on cytotoxicity and competitive flow cytometry assays using a cell line overexpressing canine P-gp. [Read the Full Post]

Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification

22 views | Oct 20 2023

Tilapia Lake Virus (TiLV) enters tilapia cells through a dynamin-mediated endocytic pathway that depends on cholesterol and the cytoskeleton, but is independent of clathrin and pH. [Read the Full Post]

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax

55 views | Oct 20 2023

The study demonstrated that the combination of the cap-dependent mRNA translation inhibitor SBI-756 with venetoclax enhances apoptosis and efficacy in DLBCL and MCL cells, highlighting a potential novel treatment approach for aggressive lymphomas. [Read the Full Post]

Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway

69 views | Oct 20 2023

The study found that kaempferol (Kae) inhibits glioma cell proliferation, promotes apoptosis, and inhibits migration and invasion, potentially through targeting EGFR/SRC/STAT3 signaling, and synergizes with gefitinib (Gef) to enhance antitumor effects, suggesting its potential as a candidate drug or chemosensitizer in glioma therapy. [Read the Full Post]

Pituitary Adenylate Cyclase Activating Polypeptide Inhibits A10 Dopamine Neurons and Suppresses the Binge-like Consumption of Palatable Food

37 views | Oct 19 2023

Pituitary adenylate cyclase-activating polypeptide (PACAP) activates PAC1 receptors and KATP channels to inhibit A10 dopamine neurons in the ventral tegmental area (VTA), resulting in a sex-dependent suppression of binge-like consumption and contributing to the regulation of energy homeostasis through the hedonic energy balance circuitry. [Read the Full Post]

Targeting lipid-sensing nuclear receptors PPAR (α, γ, β/δ): HTVS and molecular docking/dynamics analysis of pharmacological ligands as potential pan-PPAR agonists

56 views | Oct 19 2023

The study identified eprosartan as a potential PPAR pan-agonist with strong binding affinity to all PPAR isoforms, demonstrated superior stability in protein-ligand complex formation, and showed promising therapeutic effects in an in vitro model of NAFLD. [Read the Full Post]

Improved antitumor activity against prostate cancer via synergistic targeting of Myc and GFAT-1

80 views | Oct 19 2023

Simultaneous targeting of Myc and GFAT-1 using inhibitors and a nanocarrier delivery system shows promise as a novel strategy for the treatment of prostate cancer. [Read the Full Post]

Taselisib moderates neuropathic pain through PI3K/AKT signaling pathway in a rat model of chronic constriction injury

69 views | Oct 19 2023

Taselisib treatment alleviated neuropathic pain in rats by suppressing the pro-inflammatory response and modulating the PI3K/AKT signaling pathway. [Read the Full Post]

Updates and advances in pyruvate kinase deficiency

30 views | Oct 19 2023

Mutations in the PKLR gene lead to pyruvate kinase deficiency, causing chronic hemolytic anemia, and recent advancements in treatment options include the use of an oral allosteric PK activator called mitapivat and ongoing clinical trials for gene therapy. [Read the Full Post]

Improvement of the functional value of green soybean (edamame) using germination and tempe fermentation: A comparative metabolomics study

51 views | Oct 18 2023

This study demonstrated that tempe fermentation significantly increased the concentrations of important bioactive metabolites in green soybean, thereby highlighting its potential to improve the functionality of this legume. [Read the Full Post]

Arum palaestinum delays hepatocellular carcinoma proliferation through the PI3K-AKT-mTOR signaling pathway and exhibits anticoagulant effects with antimicrobial properties

21 views | Oct 18 2023

The study revealed that the aqueous extract of Arum palaestinum Boiss (AP) flowers exhibited potent antimicrobial activity, anticoagulant properties, and potential as an anticancer agent by impacting cell cycle, HCC biomarkers, and the PI3K-AKT-mTOR signaling pathway. [Read the Full Post]

Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation

28 views | Oct 18 2023

Zinc chelation potentiates platelet prostacyclin (PGI2) signaling, resulting in increased inhibition of platelet activation, aggregation, and thrombus formation. [Read the Full Post]

Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer

57 views | Oct 18 2023

The study demonstrates that β-Arrestin 1 (ARRB1) plays a crucial role in gastric cancer cell metabolism and proliferation, with its subcellular localization determining its dual functions and suggesting the therapeutic potential of targeting the ARRB1-PKM2 axis. [Read the Full Post]

AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma

36 views | Oct 18 2023

AURKB inhibitors show promise as a therapeutic strategy for uveal melanoma by epigenetically silencing the expression of the oncogenic telomerase reverse transcriptase (TERT). [Read the Full Post]

Investigation of Fenebrutinib Metabolism and Bioactivation Using MS3 Methodology in Ion Trap LC/MS

29 views | Oct 17 2023

Fenebrutinib, an orally available Bruton tyrosine kinase inhibitor, has been characterized through in silico and in vitro studies, elucidating its metabolites and reactive intermediates, which can aid in understanding its adverse effects and facilitate the development of safer drugs. [Read the Full Post]

Porcine cardiac blood - Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K/AKT/Bcl-2/Bax signaling pathway

49 views | Oct 17 2023

PCB-DS, a combination of Salvia miltiorrhiza and porcine cardiac blood, alleviates cerebral ischemia/reperfusion injury (CIRI) by inhibiting oxidative stress-induced apoptosis through the PI3K/AKT/Bcl-2/Bax signaling pathway. [Read the Full Post]

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer

58 views | Oct 17 2023

Metformin inhibits the populations of myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment of colon cancers through AMPK activation, mTOR inhibition, and downregulation of the mevalonate pathway. [Read the Full Post]

Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study

24 views | Oct 17 2023

This study reveals that the accumulation of phosphorylated α-synuclein and Toll-like receptor 2 signaling in Schwann cells are implicated in disrupted gut homeostasis, highlighting the potential of targeting the TLR2-mediated pathway as a therapy for gastrointestinal dysfunction in Parkinson's disease. [Read the Full Post]

Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer

63 views | Oct 17 2023

Targeting DNA damage response and repair pathways with inhibitors of cell-cycle checkpoint proteins represents a promising strategy to overcome radioresistance and improve the sensitivity of colorectal cancer cells to radiotherapy, with potential for combination therapies involving immunotherapy. [Read the Full Post]