Beclin

Development of an autophagy activator from Class III PI3K complexes, Tat-BECN1 peptide: Mechanisms and applications

49 views | Aug 14 2023

Tat-BECN1 peptide, derived from Beclin 1 subunit of Class III PI3K complexes, shows promise as a specific autophagy activator and has demonstrated potential therapeutic applications in various physiological and pathological models, although further research is required for clinical translation. [Read the Full Post]

Microneedle-assisted vaccination combined with autophagy regulation for antitumor immunotherapy

64 views | Aug 14 2023

The whole cell-encapsulated antitumor vaccine microneedle patch (TCV-DMNs) combined with transdermal co-delivery of GM-CSF and Tat-beclin 1 promotes effective antigen delivery, enhances dendritic cell activation and antigen presentation through autophagy regulation, resulting in a robust antitumor immune response and extended survival. [Read the Full Post]