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Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

56 views | Sep 28 2023

This study identified fibroblast activation protein (FAP) and dipeptidyl peptidase-4 (DPP4) as proteases responsible for cleaving the cellular prion protein (PrPC), with their activity and modulation affecting the physiology and pathogenic potential of PrPC and its associated diseases. [Read the Full Post]