Others

Comparing the Reliability of the Glomerular Filtration Rate Estimated with 99m-Technetium Diethylene-Triamine-Pentaacetate versus the Effective Renal Plasma Flow Obtained with 99m-Technetium Ethylene Dicysteine: A Prospective Observational Study

23 views | Feb 16 2024

The study compared different methods of estimating glomerular filtration rate (GFR) in patients with varying renal function, concluding that in individuals with renal dysfunction, calculating GFR from effective renal plasma flow (ERPF) obtained via 99m-technetium ethylene dicysteine (99mTc-EC) was more accurate than other techniques, particularly in contrast to Gates' method using a gamma camera, which tended to overestimate GFR. [Read the Full Post]

Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil

23 views | Feb 16 2024

This study demonstrates the potential of thiolated β-CD-based nanoparticles loaded with Minoxidil as an effective and non-irritating drug delivery system for treating scalp diseases topically. [Read the Full Post]

In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach

25 views | Feb 15 2024

The comprehensive computational analysis conducted on chlorogenic acid derivatives strongly indicates their potential as powerful inhibitors for the treatment of breast cancer, outperforming certain standard drugs in docking scores and demonstrating promising interactions and favorable ADME profiles. [Read the Full Post]

Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases

24 views | Feb 15 2024

This research demonstrates that modifying liposomes to carry a mitochondrial poison selectively targets and diminishes the mitochondrial function of specific cancer cells, showcasing promising advancements in targeted anticancer therapy. [Read the Full Post]

Effects of Plant Regulators on the Seed Germination and Antioxidant Enzyme Activity of Cotton under Compound Salt Stress

25 views | Feb 14 2024

Soaking treatments employing compound sodium nitrophenolate (CSN) and 24-epibrassinolide (EBR) effectively enhance cotton germination under high-salt conditions by bolstering antioxidant enzyme activities, showcasing promising potential to improve cotton's salt tolerance. [Read the Full Post]

Diallyl disulfide synergizes with melphalan to increase apoptosis and DNA damage through elevation of reactive oxygen species in multiple myeloma cells

16 views | Feb 12 2024

The study underscores the potential of combining DADS, a compound found in garlic, with melphalan as a promising strategy for enhancing the efficacy of multiple myeloma treatment through induced apoptosis and increased DNA damage in MM cells. [Read the Full Post]

CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells

21 views | Feb 12 2024

The CD74-ROS1 L2026M mutation in NSCLC cells induces increased invasion, metastasis, and crizotinib resistance via the MEK/ERK pathway-mediated autophagy, highlighting MEK as a potential target for reversing these processes and enhancing treatment efficacy. [Read the Full Post]

Enantioselectivity in the enzymatic dehydration of malate and tartrate: Mirror image specificities of structurally similar dehydratases

22 views | Feb 12 2024

The switch in substrate stereospecificity between fumarate hydratase and L-tartrate dehydratase may be attributed to subtle conformational adjustments and amino acid flexibility in the active site, potentially facilitated by the enantiomer superposition model. [Read the Full Post]

Heterostructured BiVO4/CoPi nanoarrays as high-efficiency photoanode and AuPt nanodendrites as nanozyme for sensitive sensing of miRNA 141

29 views | Feb 11 2024

A highly sensitive BiVO4/CoPi heterostructured PEC biosensor utilizing AuPt nanodendrites as a nanozyme has been developed, exhibiting a wide linear range from 5 fM to 1 pM and an ultra-low detection limit of 0.17 fM for miRNA 141, offering valuable prospects for precise tumor biomarker analysis in clinical applications. [Read the Full Post]

Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer

27 views | Feb 10 2024

The study elucidates the pivotal role of the HBP1/TIMP3 axis in suppressing breast cancer tumorigenesis and progression while enhancing sensitivity to radiation and hormone therapies, unveiling promising prospects for novel treatment modalities and improved prognostic approaches. [Read the Full Post]