SCD

Targeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinoma

23 views | Jan 07 2024

Targeting Stearoyl-coa desaturase 1 (SCD1) using MF-438 induced ferroptosis, enhanced immunogenicity, and improved radiation sensitivity in esophageal squamous cell carcinoma (ESCC), offering potential therapeutic avenues and identifying SCD1 as a prognostic marker for ESCC survival. [Read the Full Post]

Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication

20 views | Nov 15 2023

Stearoyl-CoA desaturase-1 (SCD1) inhibitors, such as MK8245 and #1716, have shown potent and broad-spectrum suppression of Dengue virus replication, suggesting their potential as novel antiviral candidates for treating dengue fever and related flavivirus infections. [Read the Full Post]

Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence

26 views | Sep 15 2023

The study demonstrates that manipulating the stearate/oleate ratio through inhibition of SCD-1, along with depletion of CPT1C, could be a promising strategy for cancer therapy by inducing tumor cell senescence and inhibiting proliferation. [Read the Full Post]