Blog of Signaling Pathways

Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

34 views | Jul 24 2023

Sodium citrate, when used at low concentrations, exhibits significant anti-virulence and anti-biofilm activity against Serratia marcescens, making it a safe and effective food additive for preventing contamination and spoilage. [Read the Full Post]

Matching-Adjusted Indirect Comparisons of Diroximel Fumarate, Ponesimod, and Teriflunomide for Relapsing Multiple Sclerosis

43 views | Jul 24 2023

The analysis comparing Diroximel fumarate (DRF) to Ponesimod (PON) and Teriflunomide (TERI) in the treatment of relapsing multiple sclerosis did not find strong evidence of differences in most clinical and radiological outcomes between DRF and PON, but showed improved efficacy of DRF compared to TERI for all outcomes except absence of new/newly enlarging T2 lesions. [Read the Full Post]

Thiomyristoyl ameliorates colitis by blocking the differentiation of Th17 cells and inhibiting SIRT2-induced metabolic reprogramming

32 views | Jul 24 2023

The study suggests that treatment with TM, a compound that targets SIRT2, reduces the progression of ulcerative colitis by inhibiting Th17 cell differentiation, promoting LDHA acetylation, and modulating inflammatory cytokines. [Read the Full Post]

Efficacy and tolerability of isocitrate dehydrogenase inhibitors in patients with acute myeloid leukemia: A systematic review of clinical trials

22 views | Jul 23 2023

Isocitrate dehydrogenase (IDH) inhibitors, particularly ivosidenib for IDH-1 and enasidenib for IDH-2 mutations, demonstrate safety and efficacy in treating newly diagnosed medically unfit or relapsed/refractory acute myeloid leukemia (AML) patients with IDH mutations, improving objective response rates and survival outcomes, although further studies are necessary to validate these findings and compare them with other targeted therapies. [Read the Full Post]

[Novel Strategies to Treat Acute Myeloid Leukemia]

24 views | Jul 23 2023

Novel treatment strategies for acute myeloid leukemia (AML) based on patient-related and disease-specific factors, including targeted therapies, consolidation with chemotherapy or allogeneic hematopoietic cell transplantation, and maintenance therapy, show promise in improving outcomes for AML patients. [Read the Full Post]

Therapies for acute myeloid leukemia in patients ineligible for standard induction chemotherapy: a systematic review

107 views | Jul 23 2023

Targeted therapy combined with a hypomethylating agent shows the most promising results in terms of overall survival and event-free survival for patients with acute myeloid leukemia (AML) who are ineligible for first-line induction chemotherapy, although combination therapies are associated with a higher incidence of adverse events. [Read the Full Post]

A phase Ib/II study of ivosidenib with venetoclax +/- azacitidine in IDH1-mutated myeloid malignancies

17 views | Jul 23 2023

The combination of the IDH1 inhibitor ivosidenib, the BCL2 inhibitor venetoclax, and azacitidine demonstrated favorable safety and efficacy profiles, with high response rates, durable remissions, and potential benefits for patients with IDH1-mutated myeloid malignancies, including those with signaling gene mutations. [Read the Full Post]

Inhibition of Autotaxin Ameliorates LPA-Mediated Neuroinflammation and Alleviates Neurological Dysfunction in Acute Hepatic Encephalopathy

29 views | Jul 23 2023

The study demonstrated that treatment with an autotaxin inhibitor attenuated neuroinflammation, reduced levels of LPA and inflammatory markers, improved neurobehavioral symptoms, and ameliorated brain edema in a mouse model of hepatic encephalopathy. [Read the Full Post]

Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth

46 views | Jul 22 2023

Tanshinone IIA (T2A), derived from the Chinese herb Danshen, inhibits cellular proliferation and reduces mTORC1 activity through increased expression of sestrin, suggesting its potential as a novel therapeutic agent for glioblastomas when used in combination with PI3K inhibitors. [Read the Full Post]

Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma

27 views | Jul 22 2023

Multiparametric MR-PET imaging utilizing composite biomarkers can effectively quantify the response to GDC-0084 treatment, estimate pharmacokinetic parameters, and predict progression-free survival in patients with recurrent malignant gliomas. [Read the Full Post]

Inflammatory Response and Exosome Biogenesis of Choroid Plexus Organoids Derived from Human Pluripotent Stem Cells

59 views | Jul 22 2023

This study investigates the impact of Wnt signaling on inflammatory response and extracellular vesicle biogenesis in choroid plexus organoids derived from human-induced pluripotent stem cells, providing a model for drug screening and designing drug delivery systems for neurological disorders such as Alzheimer's disease and ischemic stroke. [Read the Full Post]

Combining ReACp53 with Carboplatin to Target High-Grade Serous Ovarian Cancers

34 views | Jul 22 2023

The combination of ReACp53 and carboplatin has shown promising synergistic effects in targeting high-grade serous ovarian carcinomas, potentially offering a new therapeutic strategy for this aggressive subtype of ovarian cancer. [Read the Full Post]

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing

83 views | Jul 22 2023

The study reveals that Krüppel-like factor 5 (KLF5) positively regulates β-secretase (BACE1) and promotes amyloidogenic cleavage of amyloid precursor protein (APP), suggesting that targeting KLF5 or its downstream effects could be a potential strategy for preventing Alzheimer's disease progression. [Read the Full Post]

Treating colorectal peritoneal metastases with an injectable cytostatic loaded supramolecular hydrogel in a rodent animal model

79 views | Jul 21 2023

The experimental study demonstrated that treatment of peritoneal metastases with a supramolecular hydrogel loaded with mitomycin C (MMC) significantly improved overall survival compared to treatment with free MMC alone, suggesting the potential of this drug delivery system for enhancing therapeutic efficacy. [Read the Full Post]

Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition

53 views | Jul 21 2023

The recent study reveals that the C12 thiol in KRASG12C exhibits a depressed pKa and susceptibility to chemical ligation, as well as oxidation, providing insights for drug discovery and indicating the occurrence of unknown biological consequences. [Read the Full Post]

Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

75 views | Jul 21 2023

This computational study provides a comprehensive understanding of the reaction mechanism and kinetic constants involved in the covalent binding of ARS-853 to the KRASG12C·GDP complex, offering insights into the design of selective covalent inhibitors for challenging RAS-like proteins. [Read the Full Post]

A case of nocardiosis in a patient with ulcerative colitis on chronic corticosteroids, infliximab, and upadacitinib

104 views | Jul 21 2023

Immunosuppressed patients, particularly those with ulcerative colitis, are at an increased risk of unmasking obscure infections, necessitating early detection and treatment to mitigate the associated morbidity and mortality. [Read the Full Post]

The differential effects of upadacitinib treatment on skin rashes of four anatomical sites in patients with atopic dermatitis

38 views | Jul 21 2023

Upadacitinib demonstrated higher therapeutic efficacy in reducing skin rashes in the lower limbs compared to the trunk and head and neck in patients with moderate-to-severe atopic dermatitis. [Read the Full Post]

Melatonin promotes orofacial antinociception in adult zebrafish by modulating TRP channels

97 views | Jul 20 2023

Melatonin demonstrated an orofacial antinociceptive effect in adult zebrafish, which was associated with the modulation of TRP channels, particularly TRPV1. [Read the Full Post]

Treatment satisfaction with molidustat in CKD-related anemia in non-dialysis patients: a post-hoc analysis of two clinical trials

33 views | Jul 20 2023

The post-hoc analysis suggests that molidustat may offer improved treatment satisfaction and convenience compared to darbepoetin alfa for patients with non-dialysis chronic kidney disease and renal anemia. [Read the Full Post]