Blog of Signaling Pathways

Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells

21 views | Jan 31 2024

The study identifies that tamoxifen-resistant breast cancer cells depend on enhanced glycolysis, particularly lactate metabolism mediated by MCT1 and LDHB, proposing that targeting these pathways could offer a promising strategy for treating tamoxifen-resistant breast cancer. [Read the Full Post]

Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis

35 views | Jan 31 2024

CFI-400945 demonstrates dual effects by inhibiting neointima formation while accelerating atherosclerosis, attributed to its induction of mitotic arrest, polyploidization, and apoptosis in smooth muscle cells. [Read the Full Post]

Tumor Microenvironment Responsive CD8+ T Cells and Myeloid-Derived Suppressor Cells to Trigger CD73 Inhibitor AB680-Based Synergistic Therapy for Pancreatic Cancer

27 views | Jan 31 2024

AB680, a potent CD73 inhibitor, demonstrates significant efficacy in augmenting CD8+ T cell infiltration, prolonging survival, and when combined with PD-1 blockade while attenuating gemcitabine's effects, offering a promising immunotherapeutic strategy in pancreatic ductal adenocarcinoma. [Read the Full Post]

Apparent and true digestibility of macro and micro nutrients in adult maintenance dog foods containing either a majority of animal or vegetable proteins1

22 views | Jan 31 2024

This study investigates mineral digestibility in canines fed different diets, revealing significant differences in apparent and true digestibility values and suggesting a need for refined models to comprehensively understand nutrient absorption in dogs. [Read the Full Post]

Identification and characterization of an ectophosphatase activity involved in Acanthamoeba castellanii adhesion to host cells

22 views | Jan 31 2024

The ectophosphatase activity in Acanthamoeba castellanii, particularly stimulated by mannose residues, appears crucial for trophozoite adhesion to host cells, suggesting a pivotal role in the pathogenesis of associated infections. [Read the Full Post]

Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases

14 views | Jan 30 2024

The distinction between fast and slow blood-brain barrier transport mechanisms for peptide incretin receptor agonists underscores their potential as rapid-acting therapeutics for Alzheimer's and Parkinson's diseases. [Read the Full Post]

225Ac-iPSMA-RGD for Alpha-Therapy Dual Targeting of Stromal/Tumor Cell PSMA and Integrins

26 views | Jan 30 2024

The preclinical evaluation of 225Ac-iPSMA-RGD demonstrates its cytotoxicity, biodistribution, and therapeutic potential, suggesting promise for targeted alpha therapy in treating colorectal cancer. [Read the Full Post]

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis: a look towards 2023 and beyond

27 views | Jan 30 2024

Advances in IPF research are driving an exponential surge in clinical trials testing novel treatments, aiming not only to stabilize but potentially reverse the fibrotic process, signaling a promising shift toward expanded therapeutic options and improved patient outcomes. [Read the Full Post]

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

20 views | Jan 30 2024

The study underscores the pivotal role of IGF2BP2 in acute myeloid leukemia, revealing its association with unfavorable prognosis, promotion of leukemia cell development through m6A-dependent regulation of key metabolic targets, and the promising therapeutic potential of the identified small-molecule compound (CWI1-2) in targeting IGF2BP2 for AML treatment. [Read the Full Post]

Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer

41 views | Jan 30 2024

The discovery of SU056, a potent YB-1 inhibitor exhibiting multifaceted impacts on ovarian cancer progression, apoptosis promotion, and synergy with paclitaxel while reducing treatment-associated toxicities, suggests a promising strategy for combating tumor growth and treatment resistance. [Read the Full Post]

Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system

62 views | Jan 29 2024

The identification of significant safety signals for interstitial lung disease associated with several FDA-approved antibody-drug conjugates underscores the critical need for heightened clinician awareness and early patient monitoring, prompting further research and potential adjustments in clinical practice guidelines. [Read the Full Post]

Axillary Nodal Response to Neoadjuvant T-DM1 Combined with Pertuzumab in a Prospective Phase II Multi-Institution Clinical Trial

56 views | Jan 29 2024

In HER2-positive breast cancer patients undergoing neoadjuvant dual HER2-targeted therapy, achieving a pathologic complete response or residual cancer burden I in the breast strongly correlates with a high probability of having no residual disease in the axillary lymph nodes, suggesting a potential consideration for omitting axillary surgical staging in future trials for those demonstrating these favorable responses. [Read the Full Post]

18F-FDG and 18F-AIF-NOTA-Octreotide PET/CT Confirmed a Rare Case of Cutaneous Merkel Cell Carcinoma With a Solitary Local Nodal Metastasis

12 views | Jan 29 2024

A 56-year-old man with cutaneous Merkel cell carcinoma and nodal metastasis underwent radical treatment following a specialized 18F-AIF-NOTA-octreotide PET/CT confirmation of a solitary somatostatin receptor-positive left inguinal mass, guiding a more targeted therapeutic approach. [Read the Full Post]

Recurrent bilateral idiopathic chylothorax: a therapeutic challenge

19 views | Jan 29 2024

The multidisciplinary management involving total parenteral nutrition, octreotide, thoracic duct embolisation, and ultimately thoracic duct ligation with talc pleurodesis proved effective in resolving the persistent bilateral idiopathic chylothorax, showcasing the intricate yet successful approach to this challenging condition. [Read the Full Post]

Management of chronic HBV-HDV patients chronic HBV-HDV infection: A review on new management options

15 views | Jan 29 2024

Despite its discovery almost 50 years ago by Mario Rizzetto, Hepatitis D remains a challenge due to limited progress in diagnosis and treatment, with the recent approval of bulevirtide marking a significant but incomplete advancement in addressing this chronic viral hepatitis. [Read the Full Post]

vPIF-1 is an insulin-like antiferroptotic viral peptide

32 views | Jan 28 2024

The study reveals how viral insulin-like peptides, exemplified by LCDV-1 VILP, serve as potent inhibitors of ferroptosis, highlighting their specificity in preventing this form of cell death and suggesting a potential viral defense mechanism in lower organisms. [Read the Full Post]

Temporal landscape of mitochondrial proteostasis governed by the UPRmt

24 views | Jan 28 2024

The study elucidates the intricate network of mitochondrial proteostasis controlled by the unfolded protein response (UPRmt), showcasing its pivotal role in safeguarding and repairing damaged mitochondrial proteins, particularly emphasizing its impact on oxidative phosphorylation metabolism and its interplay with PINK1/Parkin-mediated mitophagy for cellular recovery during stress. [Read the Full Post]

Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain

38 views | Jan 28 2024

The study compared various glutamate receptor agonists' impact on inducing excitotoxic brain damage in rats, revealing PUT as a potential general marker of such damage due to its concurrent increase with brain injury following both ionotropic and metabotropic glutamate receptor activation. [Read the Full Post]

Role of ON and OFF Visual Pathways in Rod- and Cone-Driven Flicker Responses

44 views | Jan 28 2024

The study identified distinct neurotransmitter effects on rod and cone-driven flicker responses, emphasizing the involvement of ON and OFF visual pathways, horizontal cells, and the sensitivity of low-frequency flicker in ophthalmic pathophysiological research. [Read the Full Post]

Response-guided neoadjuvant sacituzumab govitecan for localized triple negative breast cancer: results from the NeoSTAR trial

24 views | Jan 28 2024

The neoadjuvant trial of sacituzumab govitecan in early-stage triple-negative breast cancer demonstrated a 30% pathological complete response rate with manageable adverse events, emphasizing the potential of SG as a single agent and the need for further research into optimal treatment duration and combination strategies. [Read the Full Post]