PTEN

Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events

20 views | Nov 24 2023

The discovery that PTEN serves as a critical early stress sensor, modulating Fyn kinase activation, mitochondrial dysfunction, and neuroinflammation, establishes it as a promising pharmacological target for the development of novel therapeutic strategies in Parkinson's disease. [Read the Full Post]

Silencing of RhoC induces macrophage M1 polarization to inhibit migration and invasion in colon cancer via regulating the PTEN/FOXO1 pathway

25 views | Nov 04 2023

This study shows that silencing RhoC in colon cancer cells reduces invasion, migration, and tumor growth by suppressing M2 macrophage polarization and modulating the PTEN/FOXO1 pathway. [Read the Full Post]

The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines' De Novo Synthesis

77 views | Aug 17 2023

This study elucidates the role of HDAC1 and the AKT-mTOR signaling pathway in promoting FMDV replication, while also highlighting the importance of the CAD ACTase domain and de novo pyrimidine synthesis, providing potential targets for the development of drugs against Foot-and-mouth disease virus. [Read the Full Post]

Development of a colloidal gold immunochromatographic strip with enhanced signal for the detection of bovine parvovirus

47 views | Aug 17 2023

The study successfully developed a signal-enhanced GICG strip with high sensitivity and specificity for detecting Bovine Parvovirus (BPV), making it a promising rapid and convenient diagnostic tool for BPV infection in the field. [Read the Full Post]

Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells

855 views | Jul 11 2018

Liu X et al. suggested that APN enhanced osteogenic differentiation of hBMSCs in vitro partially by inhibiting PTEN expression. APN could be a therapeutic agent in tissue regeneration engineering and bone regeneration by inhibiting PTEN expression and then promoting the osteogenic differentiation of hBMSCs. [Read the Full Post]