Bcl-6

BTBBCL6 dimers as building blocks for reversible drug-induced protein oligomerization

94 views | Oct 29 2023

This study characterized the BTB domain of the transcription factor BCL6 as a small-molecule-controlled, reversible oligomerization switch, enabling precise control over protein function and demonstrating its potential for synthetic biology applications. [Read the Full Post]

Safety and efficacy of single insertion accelerated MR-image guided brachytherapy following chemo-radiation in locally advanced cervix cancer: modifying our EMBRACE during the COVID pandemic

28 views | Aug 13 2023

The study showed that a modified image-guided adaptive brachytherapy protocol (mIGABT) was effective, cost-saving, and well-tolerated in treating locally advanced cervical cancer during the COVID-19 pandemic. [Read the Full Post]

Impact of SNPs, off-targets, and passive permeability on efficacy of BCL6 degrading drugs assigned by virtual screening and 3D-QSAR approach

33 views | May 15 2023

The study utilized computational methods to identify potential BCL6 inhibitors from a library of approved drugs and highlighted the importance of considering off-target effects and membrane permeability in drug design and evaluation. [Read the Full Post]