Hippo

Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin

22 | Jan 25 2024

Enhanced UVB-induced apoptosis in SLE keratinocytes is driven by overactive Hippo signaling, characterized by hypomethylation-induced WWC1 overexpression, leading to altered YAP activity and promoting cell death. [Read the Full Post]

PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish

6 | Jan 22 2024

Activation of PPARα and subsequent suppression of YAP signaling promote liver progenitor cell differentiation into hepatocytes, offering potential therapeutic insights for chronic liver disease treatment. [Read the Full Post]

PROTAC targeting cyclophilin A controls virus-induced cytokine storm

36 | Jan 19 2024

Researchers have developed PROTACs targeting Cyclophilin A (CypA), showing promise in mitigating cytokine storms by reducing proinflammatory cytokine production and improving survival rates in influenza B virus-infected mice. [Read the Full Post]

Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions

18 | Nov 09 2023

The study identified GA-017, a small molecule inhibitor of large tumor suppressor kinases, which promotes cell proliferation in 3D culture systems by stabilizing and translocating key effectors of the Hippo signaling pathway, offering promising prospects for enhancing the efficiency of 3D cell culture and organoid expansion. [Read the Full Post]

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

115 | Oct 27 2023

The study identified TNIK as a key kinase involved in procollagen I trafficking and demonstrated its potential as a therapeutic target for hepatic fibrosis. [Read the Full Post]

Novel Allosteric Effectors Targeting Human Transcription Factor TEAD

57 | Oct 15 2023

Chemical modifications of inhibitors targeting the palmitate-binding pocket in TEAD1-4 proteins have led to the discovery of allosteric inhibitors that enhance communication between TEAD4 and YAP1 domains, offering potential therapeutic strategies for solid tumors. [Read the Full Post]

Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells

31 | Sep 28 2023

Targeting TEAD autopalmitoylation in YAP-dependent cancers shows promise as a therapeutic approach, but the transient cell cycle inhibition and the activation of the VGLL3-mediated SOX4/PI3K/AKT signaling axis present limitations that can be overcome through combination therapy with TEAD and AKT inhibitors. [Read the Full Post]

A new hazard assessment workflow to assess soil contamination from large and artisanal scale gold mining

80 | Sep 04 2023

The study developed a new workflow model combining spatial mapping, compositional analysis, and geostatistical modeling to identify and assess the contamination levels and potential risks associated with artisanal and small-scale gold mining activities in the Kedougou region, emphasizing the need for comprehensive risk assessments and improved regulation. [Read the Full Post]

β-catenin ameliorates myocardial infarction by preventing YAP-associated apoptosis

81 | Aug 18 2023

The study demonstrated that upregulation of β-catenin in myocardial infarction (MI) reduces cardiac tissue damage and cardiomyocyte apoptosis, and this effect is mediated, at least in part, through the reactivation of Yes-Associated Protein (YAP). [Read the Full Post]

Activation of skeletal muscle FAPs by LPA requires the Hippo signaling via the FAK pathway

60 | Aug 11 2023

Lysophosphatidic acid (LPA) activates fibro/adipogenic progenitors (FAPs) in skeletal muscle by signaling through LPA1, promoting FAK phosphorylation and subsequent activation of the Hippo pathway. [Read the Full Post]

Hypoxia-induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells

113 | Mar 08 2023

The study suggests that hypoxia-induced YAP activation is positively associated with mesenchymal TNBC cell migration and may be a novel factor responsible for promoting the aggressive behavior of TNBC cells under hypoxic conditions. [Read the Full Post]

Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats

74 | Nov 26 2022

Yuchen Zhou et al. found that theta is the dominant frequency of cross-frequency coupling between the MEC and hippocampus, with hippocampal gamma largely independent of entorhinal gamma. [Read the Full Post]

TAZ Induces Migration of Microglia and Promotes Neurological Recovery After Spinal Cord Injury

16 | Sep 09 2022

Xuyang Hu et al. found that TAZ mediated microglial migration to the edge of the lesion core, promoting the formation of microglial scars and functional recovery after SCI. [Read the Full Post]

Inhibitory Effect of Hemiscorpius lepturus Scorpion Venom Fractions on Tachyzoites of Toxoplasma gondii

45 | Sep 02 2022

Lida Khaleghi Rostamkolaie et al. found that the scorpion venom-purified fractions possessed anti-parasitic activity against the tachyzoite of T. gondii and could be used in parasite-controlling studies. [Read the Full Post]

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis

111 | Sep 01 2022

Yuegui Guo et al. identified HHEX as a positive modulator of YAP/TEAD to promote colorectal tumorigenesis, providing a new therapeutic strategy for targeting YAP/TEAD in CRC. [Read the Full Post]

Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

301 | May 08 2022

Long-Fei Mao et al. suggested that compound 3d suppressed cancer cell proliferation through the EGFR-TK pathway. [Read the Full Post]

Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease

480 | Jan 03 2022

H S Nandini et al. provided evidence for use of OSE, LEV and OSE+LEV against AD and epilepsy associated with AD in Aβ induced AD animal model. [Read the Full Post]

Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

234 | Oct 18 2021

Jingjing Zhang et al. found unrecognized functions of astrocytic YAP in the prevention of demyelination through promoting cholesterol synthesis in EAE, and revealed a novel pathway of YAP/HMGCS1 for cholesterol synthesis in EAE pathology. [Read the Full Post]

In silico evaluation of the downstream effect of mutated glucagon is consistent with higher blood glucose homeostasis in Galliformes and Strigiformes

322 | Oct 11 2021

Karim Mahnam et al. suggested this mutation, which leaded to stronger binding affinity of mutated glucagon to its receptor, might be a driving force for higher blood glucose homeostasis in the related birds. [Read the Full Post]

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid

405 | Oct 10 2021

Léa Mélin et al. found that LM98 reduced the expression of CTGF and Cyr61, inhibited MDA-MB-231 breast cancer cell migration and arrested cell cycling in the S phase during cell division. [Read the Full Post]

Treatment outcomes of erlotinib plus gemcitabine as late-line chemotherapy in unresectable pancreatic cancer

688 | Jun 16 2021

Takafumi Mie et al. found that benefits of erlotinib plus gemcitabine as late-line chemotherapy were limited, particularly with respect to PFS. [Read the Full Post]

Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms

709 | Jan 12 2021

Antoine Kavaye Kandeda et al. suggested that anti-inflammatory mechanisms were involved in the antiepileptogenic effect of P. daemia extract. [Read the Full Post]

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice

297 | Oct 22 2020

Qiuyun Tian et al.suggested that inhibition of YAP pathway could be a potential therapeutic target for anxiety-like behavior induced by neuro-inflammation. [Read the Full Post]

Circulating glucagon-like peptide-1 level in patients with liver cirrhosis

354 | Oct 13 2020

Masoud Nouri-Vaskeh et al. found that larger prospective studies were needed to explore the incretin effect in cirrhosis patients compared with healthy individuals. [Read the Full Post]

TM4SF1 facilitates non-small cell lung cancer progression through regulating YAP-TEAD pathway

293 | Oct 10 2020

X-Y Fu et al. demonstrated that TM4SF1 could promote proliferation, migration, and invasion in NSCLC, at least partially through a potential YAP-TEAD signaling pathway-dependent mechanism. [Read the Full Post]