IFN

Putative nucleotide-based second messengers in archaea

23 views | Dec 06 2023

Nucleotide-based second messengers in archaea, including cyclic di-AMP and cyclic oligoadenylates, have been identified with specific roles in osmoregulation and Type III CRISPR-Cas defense, while other putative second messengers await further characterization, highlighting the complexity of cellular signaling in these organisms. [Read the Full Post]

Clinical Utility of Deucravacitinib for the Management of Moderate to Severe Plaque Psoriasis

99 views | Sep 05 2023

Deucravacitinib, a first-in-class TYK2 small molecule inhibitor, shows significant clinical efficacy and a favorable safety profile in the treatment of moderate-to-severe psoriasis based on a systematic review and meta-analysis of randomized controlled trials. [Read the Full Post]

Deuterium in drug discovery: progress, opportunities and challenges

152 views | Sep 05 2023

Deuteration, the substitution of a hydrogen atom with its heavy isotope deuterium, has emerged as a promising strategy in drug discovery and development, offering the potential to enhance drug efficacy and safety through improved pharmacokinetic and toxicity profiles. [Read the Full Post]

5-FU mediated depletion of myeloid suppressor cells enhances T-cell infiltration and anti-tumor response in immunotherapy-resistant lung tumor

170 views | Jul 19 2023

Depletion of MDSCs using low-dose 5-fluorouracil (5-FU) chemotherapy showed significant anti-tumor effects by increasing the infiltration of CD8+ cytotoxic T-cells in a cold tumor model of Lewis Lung Carcinoma (LLC). [Read the Full Post]

PHLPP1 regulates PINK1-parkin signalling and life span

79 views | May 08 2023

PHLPP1 regulates mitochondrial homeostasis by promoting tubularity or fragmentation depending on cellular conditions and interacts with calcineurin and PINK1 under basal conditions, while its depletion in C. elegans leads to mitochondrial fission, lifespan extension, and enhanced survival under oxidative stress. [Read the Full Post]

Microglial VDAC1 signaling modulates sleep deprivation-induced transition to chronic postsurgical pain

49 views | Apr 18 2023

This study demonstrates that sleep deprivation before and after surgery increases the risk of chronic pain by activating spinal microglia, and that VDAC1 signaling regulates microglial activation-related ATP release, inflammation, and pain chronicity in mice. [Read the Full Post]

Nanodroplet-enhanced sonodynamic therapy potentiates immune checkpoint blockade for systemic suppression of triple-negative breast cancer

153 views | Feb 25 2023

The combination of STING activation, hypoxia relief, and sonodynamic therapy with anti-PD-L1 therapy using an O2-filled nanodroplet shows strong efficacy in suppressing triple-negative breast cancer growth and improving therapeutic outcome by promoting mature DCs, inducing immunogenic cell death, and enhancing tumor infiltration of CTLs. [Read the Full Post]