Acyltransferase

Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology

29 views | Nov 26 2023

DGAT2 inhibitors, exemplified by ervogastat, offer a promising and well-tolerated therapeutic approach for patients with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and NASH with liver fibrosis, in contrast to limited efficacy and adverse effects associated with DGAT1 inhibitors. [Read the Full Post]

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

58 views | Nov 01 2023

Inhibition of IRE1α in triple negative breast cancer cells leads to DGAT2-dependent accumulation of triacylglycerols (TAGs) and sensitizes the cells to nutritional stress, highlighting the importance of IRE1α RIDD activity in reprogramming cellular lipid metabolism. [Read the Full Post]

The pro-inflammatory effect of triglyceride on human CD4+ T cells and experimental autoimmune uveitis

54 views | Mar 28 2023

Aberrant lipid metabolism, specifically increased triglyceride levels, stimulates CD4+ T cells and promotes Th1 and Th17 cell differentiation in the pathogenesis of autoimmune uveitis, and inhibition of TAG generation using A922500 can ameliorate the disease severity by down-regulating Th17 cell response and promoting apoptosis-related protein expression. [Read the Full Post]

Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy

112 views | Mar 17 2023

Researchers have designed matrix metalloproteinase-2-sensitive tumor-penetrable nanovesicles that can regulate cholesterol metabolism to enhance photodynamic cancer immunotherapy by reinvigorating the functions of CD8+ T cells and suppressing the migration of tumor cells. [Read the Full Post]

Sterol O-Acyltransferase Inhibition Ameliorates High-Fat Diet-Induced Renal Fibrosis and Tertiary Lymphoid Tissue Maturation after Ischemic Reperfusion Injury

67 views | Mar 17 2023

High-fat diet-induced renal tertiary lymphoid tissues and sustained inflammation in mice with ischemic reperfusion injury were found to be associated with sterol O-acyltransferase (SOAT) 1-dependent cholesteryl ester accumulation, and SOAT1 inhibition was found to attenuate TLT formation and renal inflammation, suggesting its potential as a therapeutic target for CKD prevention and treatment. [Read the Full Post]