KLF

The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo

31 views | Oct 03 2023

The study demonstrated that the small-molecule compound SR18662, which inhibits Krüppel-like factor 5 (KLF5), significantly reduced the growth and proliferation of colorectal cancer cells, induced cell cycle arrest and apoptosis, modulated key signaling pathways, and inhibited xenograft growth in mice, indicating its potential as a therapeutic candidate for colorectal cancer. [Read the Full Post]

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing

78 views | Jul 22 2023

The study reveals that Krüppel-like factor 5 (KLF5) positively regulates β-secretase (BACE1) and promotes amyloidogenic cleavage of amyloid precursor protein (APP), suggesting that targeting KLF5 or its downstream effects could be a potential strategy for preventing Alzheimer's disease progression. [Read the Full Post]