Blog of Signaling Pathways

Lithium chloride treatments in free flying honey bee colonies: efficacy, brood survival, and within-colony distribution

21 views | Feb 08 2024

The study demonstrates the potential effectiveness of lithium chloride as an acaricide in honey bee colonies, showing high efficacy in eradicating Varroa destructor in both broodless and brood-containing colonies without long-term adverse effects, warranting further investigation for optimizing treatment duration to achieve consistently high efficacy. [Read the Full Post]

Preparation and Characterization of Modified ZrO2/SiO2/Silicone-Modified Acrylic Emulsion Superhydrophobic Coating

16 views | Feb 08 2024

Using an innovative spraying technique and a meticulously selected combination of γ-Methacryloyloxypropyltrimethoxysilane-modified ZrO2/SiO2/silicone-modified acrylic emulsion, our superhydrophobic coating showcased exceptional properties, including high contact angle, low rolling angle, wear resistance, and self-cleaning efficiency, making it ideal for critical industrial applications. [Read the Full Post]

Adenosine A1 Receptors Participate in Excitability Changes after Cortical Epileptic Afterdischarges in Immature Rats

24 views | Feb 08 2024

Adenosine A1 receptor modulation demonstrated age-dependent effects on postictal potentiation and refractoriness in rats, with A1 agonists suppressing both types of potentiation in younger rats while antagonists augmented delayed potentiation and moderately affected immediate refractoriness, indicating crucial regulatory roles of these receptors in post-seizure responses across different developmental stages. [Read the Full Post]

Reduction of excessive unfolded protein response by 4-phenylbutyric acid may mitigate procymidone-induced testicular damage in mice by changing the levels of circRNA Scar and circZc3h4

68 views | Feb 08 2024

4-PBA demonstrates promising protective effects against PCM-induced testicular injury in mice, mitigating damage by regulating specific circRNAs, such as Scar and Zc3h4, and suppressing the unfolded protein response pathway. [Read the Full Post]

[Effect of aqueous extract of Corni Fructus on Aβ_(25-35)-induced brain injury and neuroinflammation in mice with Alzheimer's disease]

23 views | Feb 08 2024

The study explored the impact of Corni Fructus extract on Aβ_(25-35)-induced Alzheimer's disease in mice, revealing its potential to ameliorate cognitive dysfunction, reduce brain injury, and modulate inflammatory responses via specific compounds within the extract. [Read the Full Post]

Selective Shielding of the (002) Plane Enabling Vertically Oriented Zinc Plating for Dendrite-Free Zinc Anode

19 views | Feb 07 2024

The innovative use of disodium lauryl phosphate as an electrolyte additive enables controlled, dendrite-free Zn plating with preferential growth on the (100) crystal plane, unlocking exceptional stability and high-performance capabilities in aqueous Zn-ion batteries. [Read the Full Post]

DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism

27 views | Feb 07 2024

The study's findings highlight the potential of EPA and DHA supplementation as effective interventions to alleviate depressive symptoms in pediatric patients with epilepsy, with EPA demonstrating particularly favorable effects by mitigating neuronal degeneration, reducing neuroinflammation, and modulating oxidative stress through distinct molecular mechanisms. [Read the Full Post]

Content of amino acids and biogenic amines in stored meat as a result of a broiler diet supplemented with β-alanine and garlic extract

32 views | Feb 07 2024

Supplementing chicken feed with garlic extract and β-alanine showed promise in increasing protein content, altering amino acid levels, and potentially reducing biogenic amine formation, improving the quality and shelf life of poultry meat during storage. [Read the Full Post]

A portable photoacoustic device for facile and sensitive detection of serum alkaline phosphatase activity

31 views | Feb 07 2024

The development of a portable photoacoustic device utilizing silver nanoparticles as a signal probe for alkaline phosphatase detection in serum, exhibiting excellent sensitivity, reproducibility, and practical application potential, marks a significant stride in bioassay innovation. [Read the Full Post]

Inhibition of protein tyrosine phosphatases unmasks vasoconstriction and potentiates calcium signaling in rat aorta smooth muscle cells in response to an agonist of 5-HT2B receptors BW723C86

19 views | Feb 07 2024

Oxidative stress-induced inhibition of protein tyrosine phosphatases unmasks the vasoconstrictive potential of serotonin 5-HT2B receptors, elucidating the intricate interplay between oxidative stress, receptor activity, and vascular dysfunction. [Read the Full Post]

CYP-catalysed Cycling of Clozapine and Clozapine- N-oxide Promotes the Generation of Reactive Oxygen Species in vitro

50 views | Feb 06 2024

This study reveals that specific CYP isoforms, particularly CYP3A4, not only drive clozapine metabolism to its major metabolites but also link to the formation of reactive species, potentially underpinning clozapine-induced toxicity in treatment-resistant schizophrenia. [Read the Full Post]

Identification and application of a novel deoxynivalenol-degrading enzyme from Youhaiella tibetensis

12 views | Feb 06 2024

YoDDH, an enzyme from Youhaiella tibetensis, exhibits potent DON-degrading capabilities under optimal conditions, making it a promising solution for combating DON contamination in food and feed industries. [Read the Full Post]

Detection of Reverse Transcriptase LAMP-Amplified Nucleic Acid from Oropharyngeal Viral Swab Samples Using Biotinylated DNA Probes through a Lateral Flow Assay

18 views | Feb 06 2024

This study presents a rapid, sensitive, and specific nucleic acid testing-point of care technique using crude throat swab samples, RT-LAMP-LFA readouts with biotinylated DNA probes, and digital semi-quantification, showcasing its potential as a versatile biosensor platform for efficient pathogen detection without the need for extensive sample processing. [Read the Full Post]

Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities

19 views | Feb 06 2024

Consuming non-sugar sweeteners appears to significantly alter both the composition and metabolic function of the microbiome in the metabolically active small bowel and stool, demonstrating distinct effects on different regions of the gut. [Read the Full Post]

Alignment of actin filament streams driven by myosin motors in crowded environments

35 views | Feb 06 2024

In a crowded cellular environment, the interplay between myosin-driven actin filament movement and ionic strength unveils a remarkable spatial patterning, offering profound insights into cytoskeletal organization within living cells. [Read the Full Post]

Sensitive fluorescence ELISA for the detection of zearalenone based on self-assembly DNA nanocomposites and copper nanoclusters

30 views | Feb 05 2024

An enzyme nanocomposite-based fluorescence ELISA method was developed, exhibiting a significantly lower limit of detection (0.26 ng mL-1) for Zearalenone in food samples compared to traditional ELISA, with high accuracy, selectivity, and potential for enhancing trace detection in ensuring food safety. [Read the Full Post]

Purification of thioredoxin reductase from Spirulina platensis by affinity chromatography and investigation of kinetic properties

32 views | Feb 05 2024

"In this study, TrxR enzyme from Spirulina platensis was successfully purified, characterized, and found to exhibit optimal activity at pH 7.0 and 40°C, demonstrating sensitivity to various metal ions, with Se4+ enhancing activity while others displayed inhibitory effects." [Read the Full Post]

β-escin activates ALDH and prevents cigarette smoke-induced cell death

38 views | Feb 05 2024

β-escin demonstrates promising potential as a cytoprotective agent against cigarette smoke-induced damage in nasal epithelial cells by enhancing ALDH activity and mRNA expression of ALDH isoforms. [Read the Full Post]

Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

32 views | Feb 05 2024

The identification of creatine within synaptic vesicles and its demonstrated impact on neuronal function suggests its potential role as a novel neurotransmitter, marking a significant advancement in understanding brain physiology and potential implications for neurological disorders. [Read the Full Post]

Integrative Pharmacology in the Treatment of Substance Use Disorders

25 views | Feb 05 2024

Navigating the intricate web of neurobiological pathways, an integrated approach targeting KYNA-NMDA-α7nAChRcentric pathophysiology presents a promising avenue for developing novel combination treatments to address substance use disorders comprehensively. [Read the Full Post]