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Dopamine Receptor Inhibitors
- Featured Inhibitors
- Inhibitors (13)
- Modulators (2)
- Chemicals (3)
- Agonists (20)
- Activator (1)
- Antagonists (52)
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S1724 | Paliperidone | Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia. |
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| S2529 | Dopamine HCl | Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
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| S5949 | Metoclopramide hydrochloride hydrate | Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic. |
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| S2461 | Domperidone | Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. This compound acts by blocking dopamine receptors, which helps to reduce symptoms of gastrointestinal distress. It is often prescribed for its antiemetic effects. |
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| S2451 | Amantadine HCl | Amantadine HCl has antiviral and anti-parkinsonian activities and is used to treat or prevent respiratory infections caused by certain viruses. It is also widely used in the treatment of Parkinson's disease. |
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| S2104 | Levosulpiride | Levosulpiride(RV-12309,S-(-)-Sulpiride) is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
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| S4569 | Fluphenazine dihydrochloride | Fluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. |
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| S4618 | Fenoldopam mesylate | Fenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
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| S4151 | Penfluridol | Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. |
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| S4631 | Prochlorperazine dimaleate salt | Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist. |
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| S2011 | Pramipexole 2HCl Monohydrate | Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. |
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| S4096 | Droperidol | Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
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| S2437 | Rotundine | Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
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| S4655 | Sulpiride | Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. |
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| E4910 | Cariprazine | Cariprazine(RGH-188, MP-214) acts primarily as a partial agonist at dopamine receptors, with pKi values of 10.07 for D3, 9.16 for D2L, and 9.31 for D2S receptors. It also acts as an antagonist forserotonin receptors, with pKi of 9.24, 8.59, 7.73, and 6.87 for5-HT2B,5-HT1A, 5-HT2A, and 5-HT2C receptors, respectively. |
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| S8097 | C-DIM12 | C-DIM12 is a Nurr1 activator that stimulates this compound mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. |
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| S5842 | Cabergoline | Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. |
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| S5862 | Metoclopramide | Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting. |
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| S1920 | Haloperidol | Haloperidol (Haldol) is an antipsychotic and butyrophenone. |
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| S2460 | Pramipexole | Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
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| S5324 | 6-OHDA (Oxidopamine hydrobromide) | 6-OHDA (Oxidopamine hydrobromide) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-OHDA (Oxidopamine hydrobromide) can be used to induce animal models of Parkinson's Disease.Solutions are unstable and should be fresh-prepared. |
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| S5714 | lurasidone | Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. This compound also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
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| S6853 | ONC206 | ONC206 is a selective antagonist of DRD2/3/4 with broad-spectrum anti-tumor activity. |
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| S2089 | Fenoldopam | Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA . |
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| S0476 | SCH-23390 hydrochloride | SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. This compound is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. It directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM. |
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| S4289 | Metoclopramide HCl | Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
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| S1771 | Chlorprothixene | Chlorprothixene(Minithixen,Truxal) has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
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| S4251 | Phenothiazine | Phenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
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| S5559 | (+/-)-tetrahydropalmatine | (+/-)-tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. |
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| S7993 | SKF38393 HCl | SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. |
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| S4219 | Azaperone | Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
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| E0125 | Raclopride | Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. This compound binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors. |
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| S4274 | Rotigotine | Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome. |
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| S3189 | Ropinirole HCl | Ropinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM. |
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| S3163 | Benztropine mesylate | Benztropine(Cogentin mesylate, Benztropine methanesulfonate) is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. |
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| S3044 | Lurasidone HCl | Lurasidone (SM-13496) is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. |
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| S5565 | Triflupromazine hydrochloride | Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class. |
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| S5481 | Molindone hydrochloride | Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
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| S3656 | Piribedil | Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. This compound also has α2-adrenergic (α2A/α2C) antagonist properties. |
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| S1789 | Tetrabenazine (Xenazine) | Tetrabenazine(Xenazine,Ro 1-9569) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. |
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| S2168 | PD128907 HCl | PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
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| S5624 | Paliperidone Palmitate | Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. |
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| S9509 | Tiapride Hydrochloride | Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders. |
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| S4731 | Perphenazine | Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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| S4933 | Lithium carbonate | Lithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). This compound is able to alter D2 dopamine receptors response. | ||
| E7849 | Haloperidol hydrochloride | Haloperidol hydrochloride is an antagonist of dopamine receptors with selectivity for D2-like receptors. It is an antipsychotic used to treat the positive symptoms of schizophrenia caused by increased dopamine activity. |
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| E1258 | Pridopidine | Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R). | ||
| S5399 | Chlorprothixene hydrochloride | Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. |
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| S7236 | Cariprazine hydrochloride | Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM). |
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| E4856 | Rotigotine Hydrochloride | Rotigotine Hydrochloride (N-0923 Hydrochloride) is a potent Agonist of dopamine receptor, with Ki values of 0.71 nM for dopamine D3 receptor, 4-15 nM for D2, D5, D4 receptors, and 83 nM for dopamine D1 receptor. It also acts as a partial agonist of the 5-HT1A receptor, and as an antagonist of the α2B-adrenergic receptor. | ||
| S9469 | Haloperidol Decanoate | Haloperidol decanoate (Halomonth) is a depot form of haloperidol with antipsychotic activity. It has potential to be used in the research of schizophrenia and schizoaffective disorder. | ||
| S0104 | Pardoprunox (SLV-308) hydrochloride | Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively. | ||
| S5707 | Aripiprazole lauroxil | Aripiprazole lauroxil(Aristada) is an extended-release prodrug of aripiprazole designed for intramuscular injection. It acts as a dopamine-serotonin system stabilizer, with a potent partial agonist for dopamine D2 and serotonin 5-HT1A receptors while an antagonist for serotonin 5-HT2A receptors. | ||
| S5796 | Vanoxerine dihydrochloride | Vanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex. |
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| S4257 | Alizapride HCl | Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting. | ||
| S5034 | Melitracen hydrochloride | Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties. | ||
| S4309 | Bromocriptine Mesylate | Bromocriptine mesylate is a dopamine receptor agonist with a Ki of 12.2 nM for D3 receptor and D2 receptor and a Ki of 1659 nM, 59.7 nM, 1691 nM for D1 receptor, D4 receptor, and D5 receptor, respectively. Bromocriptine mesylate is used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly. |
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| E4885 | Dopamine | Dopamine is a catecholamine neurotransmitter in the mammalian brain. It plays role as a modulator of cardiovascular function, catecholamine release, hormone secretion, vascular tone, renal function, and gastrointestinal motility. |
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| E6049New | Domperidone monomaleate | Domperidone monomaleate (R33812 monomaleate) is a potent antagonist of dopamine D2 receptor that acts as an antiemetic and prokinetic agent by targeting the chemoreceptor trigger zone and motor function of the stomach and small intestine. It also inhibits cardiac Na⁺ channels such as Nav1.5, suggesting a potential molecular mechanism for cardiovascular side effects like malignant arrhythmias. | ||
| S6455 | Clebopride malate | Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting. | ||
| S5428 | Promazine hydrochloride | Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. | ||
| S5066 | Pramipexole dihydrochloride | Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor. | ||
| E7427 | Dehydroaripiprazole | Dehydroaripiprazole (OPC-14857, DM-14857) is the active metabolite of aripiprazole, primarily metabolized by CYP3A4 and CYP2D6. It inhibits glutamate release from rat prefrontocortical nerve terminals by activating dopamine D2 and 5-HT1A receptors, reducing nerve terminal excitability and VDCC activation through a PKA-mediated signaling cascade, potentially contributing to its neuroprotective effects in excitotoxic injury. | ||
| S2493 | Olanzapine | Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
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| S1444 | Ziprasidone HCl | Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
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| S2452 | Amfebutamone (Bupropion) HCl | Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. |
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| S3821 | Nuciferine | Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. This compound is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor. |
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| S1642 | Methyldopa | Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
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| S4086 | Loxapine Succinate | Loxapine Succinate(NSC 759578) is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. |
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| S6301 | MPP+ iodide | MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. |
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| S4889 | Perospirone hydrochloride | Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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| S3854 | Tetrahydropalmatine hydrochloride | Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
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| S5741 | Quetiapine | Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. This compound is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. It is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. This chemical has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55. | ||
| S5153 | Tetrahydroberberine | Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. | ||
| S0318 | Ansofaxine hydrochloride | Ansofaxine hydrochloride (LY03005, LPM570065), a triple reuptake inhibitor, inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. | ||
| S5185 | Perospirone | Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively. | ||
| E4840 | Ziprasidone hydrochloride monohydrate | Ziprasidone hydrochloride monohydrate is an antipsychotic drug, a combined antagonist of 5-HT (serotonin) and dopamine receptor. It exhibits binding affinities for D2, 5-HT2A, 5-HT1A with Ki values 4.8 nM, 0.42 nM, 3.4 nM respectively. | ||
| S3913 | Pimethixene maleate | Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively. | ||
| E0388 | WQ 1 | WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893. | ||
| S6410 | Clemizole | Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. |
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| E4930 | Asenapine | Asenapine(Org 5222, HSDB8061) is a multi-target receptor antagonist. It acts as an antagonist of serotonin receptors with pKi values of 8.4-10.5, adrenoceptors with pKi values of 8.9-9.5, dopamine receptors with pKi values of 8.9-9.4 and histamine receptors with pKi values of 8.2-9.0. |
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