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Dopamine Receptor Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S1726 Levodopa Levodopa (L-DOPA) is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
PLOS ONE, March 2, 2017, e0173240
Molecular Psychiatry, 2025, 1-12
Mol Psychiatry, 2025, 10.1038/s41380-025-03374-6
Verified customer review of Levodopa
S2451 Amantadine HCl Amantadine HCl has antiviral and anti-parkinsonian activities and is used to treat or prevent respiratory infections caused by certain viruses. It is also widely used in the treatment of Parkinson's disease.
Frontiers in Microbiology, November 01, 2022, 979904
J Immunother Cancer, 2024, 12(11)e009805
Frontiers in Microbiology, 2022, 979904
S2529 Dopamine HCl Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
iScience, 2023, 26(3):106241
Cell Rep Methods, 2023, 3(10):100599
Front Microbiol, 2022, 13:979904
E4910 Cariprazine Cariprazine(RGH-188, MP-214) acts primarily as a partial agonist at dopamine receptors, with pKi values of 10.07 for D3, 9.16 for D2L, and 9.31 for D2S receptors. It also acts as an antagonist forserotonin receptors, with pKi of 9.24, 8.59, 7.73, and 6.87 for5-HT2B,5-HT1A, 5-HT2A, and 5-HT2C receptors, respectively.
ACS Pharmacology & Translational Science, October 25, 2022, 1086-1096
Journal of Developmental Biology, June 27, 2025, 22
Journal of Developmental Biology, 2025, 22
S2460 Pramipexole Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Metabolites, 2022 Jan 21, 101
Front Microbiol, 2022, 13:979904
Metabolites, 2022, 12(2)101
S4618 Fenoldopam mesylate Fenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
J Immunother Cancer, 2024, 12(11)e009805
Journal for ImmunoTherapy of Cancer, 2024, e009805
iScience, 2024, 109587
S5842 Cabergoline Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.
Neuro-Oncology, 2025, 727-742
iScience, 2024, 27(10):110862
Cells, 2022, 3344
S2011 Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
British Journal of Pharmacology, 2024, 3336-3352
Front Microbiol, 2022, 13:979904
Autophagy, 2016, 12(12):2374-2385
S7236 Cariprazine hydrochloride Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM).
ACS Pharmacology & Translational Science, October 25, 2022, 1086-1096
Journal of Developmental Biology, June 27, 2025, 22
Fundamental & Clinical Pharmacology, July 4, 2022, 976-984
S4274 Rotigotine Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
Front Microbiol, 2022, 13:979904
Frontiers in Microbiology, 2022, 979904
Frontiers in Microbiology, 2022, 979904
S2089 Fenoldopam Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA .
iScience, 2024, 27(4):109587
iScience, 2024, 109587
Oncogene, 2016, 3103–3113
S7993 SKF38393 HCl SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Sci Rep, 2024, 14(1):4820
JCI Insight, 2023, 8(16)e170434
S3656 Piribedil Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. This compound also has α2-adrenergic (α2A/α2C) antagonist properties.
Cell Rep Methods, 2023, 3(1):100381
S4309 Bromocriptine Mesylate Bromocriptine mesylate is a dopamine receptor agonist with a Ki of 12.2 nM for D3 receptor and D2 receptor and a Ki of 1659 nM, 59.7 nM, 1691 nM for D1 receptor, D4 receptor, and D5 receptor, respectively. Bromocriptine mesylate is used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.
PLoS One, March 02, 2017, e0173240
S2168 PD128907 HCl PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
Brain Behav Immun, 2021, 101:165-179
E4856 Rotigotine Hydrochloride Rotigotine Hydrochloride (N-0923 Hydrochloride) is a potent Agonist of dopamine receptor, with Ki values of 0.71 nM for dopamine D3 receptor, 4-15 nM for D2, D5, D4 receptors, and 83 nM for dopamine D1 receptor. It also acts as a partial agonist of the 5-HT1A receptor, and as an antagonist of the α2B-adrenergic receptor.
S0104 Pardoprunox (SLV-308) hydrochloride Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.
S5707 Aripiprazole lauroxil Aripiprazole lauroxil(Aristada) is an extended-release prodrug of aripiprazole designed for intramuscular injection. It acts as a dopamine-serotonin system stabilizer, with a potent partial agonist for dopamine D2 and serotonin 5-HT1A receptors while an antagonist for serotonin 5-HT2A receptors.
S5066 Pramipexole dihydrochloride Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
S3821 Nuciferine Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. This compound is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
Int J Neuropsychopharmacol, 2025, pyaf019
Antioxidants (Basel), 2024, 13(6)714
Br J Pharmacol, 2021, 178(5):1182-1199